A5082937222- Neuroscience and Neuropharmacology Research
- Birth, Development, and Health
- Stress Responses and Cortisol
- Neurological disorders and treatments
- Neuroendocrine regulation and behavior
- Parkinson's Disease Mechanisms and Treatments
- Diet and metabolism studies
- Receptor Mechanisms and Signaling
- Nerve injury and regeneration
- Regulation of Appetite and Obesity
- Adipose Tissue and Metabolism
- Neuropeptides and Animal Physiology
- Biochemical Analysis and Sensing Techniques
- Memory and Neural Mechanisms
- Salivary Gland Disorders and Functions
- Infant Nutrition and Health
- Neural dynamics and brain function
- Photoreceptor and optogenetics research
- Sleep and Wakefulness Research
- Rabbits: Nutrition, Reproduction, Health
- Healthcare Systems and Practices
- Biochemical effects in animals
- Neuroinflammation and Neurodegeneration Mechanisms
- Axon Guidance and Neuronal Signaling
- Epilepsy research and treatment
Nantes Université
2007-2025
PhysioPathologie des Adaptations Nutritionnelles
2015-2024
Université d'Angers
2023-2024
Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
2020-2024
Monell Chemical Senses Center
2024
University of Pennsylvania
2024
Centre National de la Recherche Scientifique
2013-2023
Inserm
2007-2023
Gènes, synapses et cognition
2021
Centre Interdisciplinaire de Recherche en Biologie
2010-2017
Food is a powerful natural reinforcer that guides feeding decisions. The vagus nerve conveys internal sensory information from the gut to brain about nutritional value; however, cellular and molecular basis of macronutrient-specific reward circuits poorly understood. Here, we monitor in vivo calcium dynamics provide direct evidence independent vagal sensing pathways for detection dietary fats sugars. Using activity-dependent genetic capture neurons activated response infusions nutrients,...
A correct interplay between dopamine (DA) and glutamate is essential for corticostriatal synaptic plasticity motor activity. In an experimental model of Parkinson's disease (PD) obtained in rats, the complete depletion striatal DA, mimicking advanced stages disease, results loss both forms plasticity: long-term potentiation (LTP) depression (LTD). However, early PD are characterized by incomplete reduction DA levels. The mechanism which this level affects glutamatergic synapses unknown. Here...
The spike-timing-dependent plasticity (STDP), a synaptic learning rule for encoding and memory, relies on relative timing of neuronal activity either side the synapse. GABAergic signaling has been shown to control excitability consequently spike timing, but whether circuits STDP remained unknown. Here we show that governs polarity STDP, because blockade GABA A receptors was able completely reverse temporal order at corticostriatal synapses in rats mice. controls both striatopallidal...
The aim of the present study was to evaluate role nitric oxide/cyclic guanosine monophosphate pathway in corticostriatal long-term depression induction a model levodopa-induced dyskinesia experimental parkinsonism. Moreover, we have also analysed possibility targeting striatal phosphodiesterases reduce dyskinesia. To synaptic plasticity sham-operated rats and 6-hydroxydopamine lesioned animals chronically treated with therapeutic doses levodopa, recordings from spiny neurons were taken using...
Corticostriatal projections constitute the main input to basal ganglia, an ensemble of interconnected subcortical nuclei involved in procedural learning. Thus, long-term plasticity at corticostriatal synapses would provide a basic mechanism for function ganglia learning and memory. We had previously reported existence anti-Hebbian spike timing-dependent (STDP) onto striatal output neurons, medium-sized spiny neurons. Here, we show that blockade GABAergic transmission reversed time dependence...
Although learning can arise from few or even a single trial, synaptic plasticity is commonly assessed under prolonged activation. Here, we explored the existence of rapid responsiveness at corticostriatal synapses in major rule, spike-timing-dependent (STDP). We found that depression (tLTD) progressively disappears when number paired stimulations (below 50 pairings) decreased whereas potentiation (tLTP) displays biphasic profile: tLTP observed for 75-100 pairings, absent 25-50 pairings and...
Abstract Parkinson's disease (PD) is characterized by the bilateral degeneration of midbrain dopamine‐containing neurons with most severe lesion in posterolateral part substantia nigra pars compacta (SNpc). In humans, such lesions lead to specific motor abnormalities (i.e., akinesia, rigidity, and tremor) that are greatly improved levodopa treatment. After a few years, beneficial effect treatment frequently offset development dyskinesias. To improve strategies, an animal model showing...
Recent findings have shifted the view of cholecystokinin (CCK) from being a cellular neuronal marker to recognized as crucial neuropeptide pivotal in synaptic plasticity and memory processes. Despite its now appreciated importance various brain regions abundance basal ganglia, role striatum, which is vital for motor control, remains unclear. This study sought fill this gap by performing comprehensive investigation CCK modulating striatal medium spiny neurons (MSN) membrane properties, well...
Inadequate nutrition during pregnancy can lead to intrauterine growth retardation and low birth weight, which in turn increases the risk of developing metabolic disorders adulthood, according various epidemiological clinical studies. The inclina-tion individuals born with weight towards palatable foods indicates a possible modification hedonic aspect their eating behavior. However, our understanding ontogenesis structural organization function within brain's reward circuits remains limited....
Perinatal maternal consumption of energy dense food increases the risk obesity in children. This is associated with an overconsumption palatable that consumed for its hedonic property. The underlying mechanism links perinatal diet and offspring preference fat still poorly understood. In this study, we aim at studying influence high-fat/high-sugar feeding [western (WD)] during gestation lactation on reward pathways controlling rat from birth to sexual maturity. We performed a longitudinal...
In both Parkinson disease and in animal models of disease, there is a microglial reaction addition to the loss dopaminergic neurons ventral midbrain. To determine pathological role this reaction, we analyzed kinetics activation cell death induced rats with neurotoxin 6-hydroxydopamine. As early as Day 1 after injection, was decline motor performance 6-hydroxydopamine-lesioned that correlated reduction innervation contralateral striatum. Loss midbrain developed few days later seemed follow...
Abstract Recently, the striatum has been implicated in spread of epileptic seizures. As absence functional scaffolding protein Bassoon mutant mice is associated with development pronounced spontaneous seizures, we utilized this new genetic model epilepsy to investigate seizure‐induced changes striatal synaptic plasticity. Mutant showed reduced long‐term potentiation spiny neurons, an altered N ‐methyl‐ d ‐aspartate (NMDA) receptor subunit distribution, whereas GABAergic fast‐spiking (FS)...
The pathogenesis of the motor fluctuations and dyskinesias that complicate levodopa treatment for Parkinson's disease (PD) remains uncertain. To evaluate relationship between degree dopamine neuron loss severity in a rodent model PD, Sprague-Dawley rats were lesioned unilaterally using different doses 6-hydroxydopamine injected into substantia nigra pars compacta (SNc). All received two daily oral one month. In most animals chronic administration induced abnormal involuntary movements...
The neural network of the enteric nervous system (ENS) underlies gastrointestinal functions. However, molecular mechanisms involved in neuronal connectivity are poorly characterized. Here, we studied role semaphorin 5A (Sema5A), previously characterized central system, on ENS connectivity. Sema5A is linked to autism spectrum disorder (ASD), a neurodevelopmental frequently associated with comorbidities, and potentially impairments. This study investigated rat neuron cultures gut explants...
The enteric nervous system (ENS) is the intrinsic that innervates entire digestive tract and regulates major functions. Recent evidence has shown functions of ENS critically rely on neuronal connectivity; however, experimental models to decipher underlying mechanisms are limited. Compared central system, for which pure cultures have been developed decades recognized as a reference in field neuroscience, an equivalent model neurons lacking. In this study, we novel highly rat embryonic with...
Fetal brain development is closely dependent on maternal nutrition and metabolic status. Maternal protein restriction (PR) known to be associated with alterations in the structure function of hypothalamus, leading impaired control energy homeostasis food intake. The objective this study was identify cellular molecular systems underlying these effects during fetal development. We combined a global transcriptomic analysis hypothalamus from rat model PR vitro neurosphere culture analyses....
Lactation is a critical period during which maternal sub- or over-nutrition affect milk composition and offspring development that can have lasting health effects. The consequences of moderate high-fat, high-simple carbohydrate diet (WD) consumption by rat dams, gestation lactation, on blood lipidome its growth, at weaning, were investigated using comprehensive lipidomic study mass-spectrometric platform combined to targeted fatty- free amino-acids analysis. This holistic approach allowed...
Highly organized circuits of enteric neurons are required for the regulation gastrointestinal functions, such as peristaltism or migrating motor complex. However, factors and molecular mechanisms that regulate connectivity their assembly into functional neuronal networks largely unknown. A better understanding by which neurotrophic this neuron circuitry is paramount to nervous system (ENS) physiology. EphB2, a receptor tyrosine kinase, essential plasticity in brain, but so far its presence...
Although many details remain unknown, several positive statements can be made about the laminar distribution of primate frontal eye field (FEF) neurons with different physiological properties. Most certainly, pyramidal in deep layer FEF that project to brainstem carry movement and fixation signals but clear evidence also support at least some deep-layer projecting superior colliculus visual responses. Thus, are functionally heterogeneous. Despite useful functional distinctions between...
Inflammatory processes in the brain may trigger specific neuroprotective responses glial cells. Here, we show that bacterial lipopolysaccharide strongly up-regulates derived neurotrophic factor (GDNF) mRNA while it down-regulates of neurturin. Tumor necrosis α (TNFα) had different effects since stimulated neurturin expression without enhancing GDNF mRNA. Interestingly, both and TNFα triggered a significant decrease receptor, GFRα1, While significance such down-regulation during inflammatory...