A5073385323- Drug Transport and Resistance Mechanisms
- Hemoglobinopathies and Related Disorders
- Cholinesterase and Neurodegenerative Diseases
- Inflammatory mediators and NSAID effects
- Pharmacogenetics and Drug Metabolism
- Drug-Induced Hepatotoxicity and Protection
- Receptor Mechanisms and Signaling
- Iron Metabolism and Disorders
- Computational Drug Discovery Methods
- Nicotinic Acetylcholine Receptors Study
- Pharmacological Effects of Natural Compounds
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Saffron Plant Research Studies
- Tuberculosis Research and Epidemiology
- HIV/AIDS drug development and treatment
- Andrographolide Research and Applications
- Analytical Methods in Pharmaceuticals
- Biochemical Analysis and Sensing Techniques
- Piperaceae Chemical and Biological Studies
- Multicomponent Synthesis of Heterocycles
- Biochemical effects in animals
- Adipose Tissue and Metabolism
- Kruppel-like factors research
- Phytochemicals and Medicinal Plants
- Cardiac electrophysiology and arrhythmias
Indian Institute of Integrative Medicine
2018-2024
University of Florida
2023-2024
Academy of Scientific and Innovative Research
2018-2024
Justus-Liebig-Universität Gießen
2023
Rajiv Gandhi Technical University
2023
Food is a powerful natural reinforcer that guides feeding decisions. The vagus nerve conveys internal sensory information from the gut to brain about nutritional value; however, cellular and molecular basis of macronutrient-specific reward circuits poorly understood. Here, we monitor in vivo calcium dynamics provide direct evidence independent vagal sensing pathways for detection dietary fats sugars. Using activity-dependent genetic capture neurons activated response infusions nutrients,...
Pinocembrin, a bioflavonoid, is extensively used in complementary/alternative medicine. It turns out as promising candidate against neurodegenerative diseases because of its multifaceted pharmacological action toward neuroprotection. However, literature evidence still lacking for inhibitory on CYP1A2, which responsible xenobiotic metabolism leading to the generation toxic metabolites and bioactivation procarcinogens. In present study, our aim was evaluate CYP1A2 potential pinocembrin via...
Bedaquiline (TMC-207) is a recently approved drug for the treatment of multidrug-resistant tuberculosis (MDR-TB). Moreover, there present and growing concern natural-product-mediated interaction, as these are inadvertently taken by patients dietary supplement, food additive, medicine. In study, we investigated impact 20 plant-based natural products, typically phenolics, on in vivo oral bedaquiline pharmacokinetics, previous studies lacking. Three phenolics were identified that can...
Rottlerin is a key bioactive phytoconstituent present in the pericarp of Mallotus philippensis. It shows promising multifaceted pharmacological actions against cancer. However, there hardly any report for quantification rottlerin biological matrix and on its pharmacokinetic behavior. Therefore, we aimed study to assess selective vitro ADME properties vivo pharmacokinetics isolated characterized using newly developed validated liquid chromatography–tandem mass spectrometry-based highly...
Abstract Many substances/drugs are administered intranasally (IN). These include opioid overdose reversal drugs, anti-epileptic medications, migraine hormone treatments, and medicines to treat/prevent allergies, colds, flues including nasally-administered vaccines, corticosteroids, antihistamines, decongestants. Additionally, IN administration is the preferred route of entry by users illicit drugs. Despite widespread use administration, there no established paradigm access this preclinically...
Diclofenac is an extensively used nonsteroidal anti-inflammatory drug, but gastrointestinal liabilities and cardiovascular complications take the shine away from such a widely prescribed drug. On other hand, rutin, dietary bioflavonoid, has quite few pharmacological attributes to improve efficacy reduce dose-related toxicities of diclofenac through intended food-drug/herb-drug interaction. The aim present research work was investigate role rutin on pharmacokinetic modulation consequent...
Myricetin, a bioflavonoid, is widely used as functional food/complementary medicine and has promising multifaceted pharmacological actions against therapeutically validated anticancer targets. On the other hand, CYP2C8 not only crucial for alteration in pharmacokinetics of drugs to cause drug interaction but also unequivocally important metabolism endogenous substances like formation epoxyeicosatrienoic acids (EETs), which are considered signaling molecules hallmarks cancer. However, there...
Curcumin, a natural diarylheptanoid, is extensively used as food additive or dietary supplement on the regular basis. It known to have potential encumber drug transporters and hepatic metabolizing enzymes that lead pharmacokinetic interactions with food. Daclatasvir new orally acting for treatment of chronic Hepatitis C Virus infections. This substrate P-glycoprotein CYP3A4 are involved in major interaction. Hence, studies' aim assess any possible interactions. Pharmacokinetic studies...
Safranal, a plant secondary metabolite isolated from saffron, has been reported for several promising pharmacological properties toward the management of Alzheimer's disease. In present study, we observe and report first time about druglike attributes safranal, such as adherence to Lipinski's rule five; optimum lipophilicity; high permeability; low blood-to-plasma ratio; less moderate propensity interact with P-glycoprotein (P-gp) or breast cancer-resistant protein (BCRP) transporters;...
Abstract Diclofenac is one of the world's largest selling nonsteroidal anti‐inflammatory drugs. The major concerns related to oral diclofenac therapy are gastrointestinal and cardiovascular side effects for which explicitly emphasis has been given use it at lowest effective dose shortest duration. On other hand, IS01957 designed under purview drug bioavailability enhancer. have dual action on inflammation nociception with acceptable safety profile. In quest a suitable combination improved...
Bedaquiline (TMC-207) is a key anti-tubercular drug to fight against multidrug resistance tuberculosis. Little information available till date on the impact of any disease state toward its pharmacokinetic behavior. The present research work aimed investigate effect renal impairment and diabetes mellitus oral pharmacokinetics bedaquiline in rat model. Renal were induced Wistar model separately using cisplatin streptozotocin, respectively, thereafter, an study was carried out individual models...
Diclofenac is a widely prescribed anti-inflammatory drug having cardiovascular complications as one of the main liabilities that restrict its therapeutic use. We aimed to investigate for any role rutin against diclofenac-induced cardiac injury with underlying mechanisms there no such precedent date. The effect (10 and 20 mg/kg) was evaluated upon concomitant oral administration fifteen days diclofenac mg/kg). Rutin significantly attenuated alterations in serum markers (LDH, CK-MB, SGOT),...
The use of adjuvant therapy is an attractive approach to manage sickle cell disease (SCD) symptomatically. present study aimed investigate the potential ellagic acid as with hydroxyurea (HU), a key drug for SCD myelosuppressive toxic effects. A panel experiments was performed using patient's blood (ex vivo) and transgenic mice model (in vivo). Ellagic exhibited following beneficial pharmacological actions: (a) potent anti-sickling, polymerization inhibitory, inherent non-hemolytic activity;...
Growing evidence suggests that inhibition of the α3β4 nicotinic acetylcholine receptor (nAChR) represents a promising therapeutic strategy to treat cocaine use disorder. Recently, aristoquinoline (
Hydroxyurea (HU) is the first-ever approved drug by USFDA for sickle cell anemia (SCA). However, its treatment associated with severe side effects like myelosuppression. Current studies are focused on supplementation therapy symptomatic management of SCA. In present study, we aimed to explore rutin's and gallic acid's potential individually, concomitant HU using pharmacokinetic pharmacodynamic approaches since there no such precedent till date. vivo in rats showed that rutin could be safely...
Being present in substantial numbers, astrocytes play an indispensable role maintaining homeostasis the brain. However, their positive or negative involvement pathological conditions brain has not been explored much. In recent years, emerging thought of targeting for resolution neurodegenerative diseases gained momentum. this study, we have attempted to explore likelihood by using a natural compound, gentiacaulein (GENT), clearance amyloid-β (Aβ) through autophagy and amelioration...
Aging is usually accompanied by mitochondrial dysfunction, reduced energy levels, and cell death in the brain other tissues. Mitochondria play a crucial role maintaining cellular through oxidative phosphorylation (OXPHOS). However, OXPHOS impaired as oxygen supply decreases with age. We explored whether pharmacologically increased diffusion crocetin can restore help delay aging of vital organs. found that aged mice treated for four months displayed significantly improved memory behavior,...
Isopropylated phenyl phosphates (IPP) are an additive organophosphate flame retardant (OPFR) that has been extensively used in furniture, electronics, automobiles, plastics, and children's products to slow down the spread of fire but its continued leaching leads toxicity concerns. Toxicological information on this important legacy contaminant is limiting. Using zebrafish, our prior whole embryonic RNA-seq data revealed disruption gene sets enriched for DNA methylation, neurotransmitter...