A5038297445- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Genetic Neurodegenerative Diseases
- Transcranial Magnetic Stimulation Studies
- Obsessive-Compulsive Spectrum Disorders
- Botulinum Toxin and Related Neurological Disorders
- Parkinson's Disease and Spinal Disorders
- Attention Deficit Hyperactivity Disorder
- Mitochondrial Function and Pathology
- Neuroscience and Neuropharmacology Research
- Cellular transport and secretion
- Neurological and metabolic disorders
- Balance, Gait, and Falls Prevention
- Folate and B Vitamins Research
- Neurotransmitter Receptor Influence on Behavior
- Advanced MRI Techniques and Applications
- RNA modifications and cancer
- Lysosomal Storage Disorders Research
- Alcoholism and Thiamine Deficiency
- Genetics and Neurodevelopmental Disorders
- Cerebrospinal fluid and hydrocephalus
- Autism Spectrum Disorder Research
- DNA Repair Mechanisms
- Genomics and Rare Diseases
- Alzheimer's disease research and treatments
Université Grenoble Alpes
2016-2025
Grenoble Institute of Neurosciences
2016-2025
Inserm
2016-2025
Centre Hospitalier Universitaire de Grenoble
2015-2024
Laboratoire de Psychologie et NeuroCognition
2013-2024
Istituti di Ricovero e Cura a Carattere Scientifico
2020-2021
Azienda Sanitaria Unità Locale di Reggio Emilia
2020-2021
University of Modena and Reggio Emilia
2020-2021
Agostino Gemelli University Polyclinic
2021
University of Milan
2021
To assess the 10-year motor outcome of deep brain stimulation subthalamic nucleus (STN-DBS) in patients with Parkinson disease (PD).Patients PD bilateral STN-DBS were assessed according to Core Assessment Program for Surgical Interventional Therapies Parkinson's Disease protocol and videotaped at baseline 1, 5, 10 years after surgery. An independent rater blinded medication condition scored video assessments.Movement Disorders Centre, Toronto Western Hospital, University Health Network,...
ABSTRACT To assess the discriminating power of multiple cerebrospinal fluid (CSF) biomarkers for Parkinson's disease (PD), we measured several proteins playing an important role in pathogenesis. The activities β‐glucocerebrosidase and other lysosomal enzymes, together with total oligomeric α‐synuclein, phosphorylated tau, were thus assessed CSF 71 PD patients compared to 45 neurological controls. Activities β‐glucocerebrosidase, β‐mannosidase, β‐hexosaminidase, β‐galactosidase established...
Apathy is one of the most common symptoms encountered in Parkinson's disease, and defined as a lack motivation accompanied by reduced goal-directed cognition, behaviour emotional involvement. In previous study we have described delayed withdrawal syndrome after successful motor improvement related to subthalamic stimulation allowing for major decrease dopaminergic treatment. This correlated with diffuse mesolimbic denervation. To confirm our hypothesis parkinsonian apathy being denervation,...
SEE SCHRAG AND POLITIS DOI101093/AWW190 FOR A SCIENTIFIC COMMENTARY ON THIS ARTICLE: Apathy, which can occur separately or in combination with depression and anxiety, is one of the most frequently encountered neuropsychiatric symptoms Parkinson's disease. Pathophysiological evidence suggests that parkinsonian apathy primarily due to a mesolimbic dopaminergic denervation, but role serotonergic alteration has never been examined, despite its well-known involvement pathogenesis anxiety. To fill...
To report on the long-term outcomes of deep brain stimulation (DBS) thalamic ventral intermediate nucleus (VIM) in Parkinson disease (PD), essential tremor (ET), and dystonic tremor.One hundred fifty-nine patients with PD, ET, dystonia underwent VIM DBS due to refractory at Grenoble University Hospital. The primary outcome was a change scores 1 year after surgery latest follow-up (21 years). Secondary included relationship between score reduction over time active contact position. Tremor...
To evaluate the effects of deep brain stimulation subthalamic nucleus (STN-DBS) on motor complications in patients with Parkinson disease (PD) beyond 15 years after surgery.Data complications, quality life (QoL), activities daily living, Unified Parkinson's Disease Rating Scale scores, dopaminergic treatment, measures, and side STN-DBS were retrospectively retrieved compared before surgery, at 1 year, bilateral STN-DBS.Fifty-one 17.06 ± 2.18 follow-up recruited. Compared to baseline, time...
SCA27B caused by FGF14 intronic heterozygous GAA expansions with at least 250 repeats accounts for 10-60% of cases unresolved cerebellar ataxia. We aimed to assess the size and frequency expanded alleles in individuals ataxia as compared controls characterize genetic clinical variability.
Abstract Obsessive-compulsive disorder (OCD) is a common and serious psychiatric disorder. Although subthalamic nucleus deep brain stimulation (DBS) has been studied as treatment for OCD patients the underlying mechanism of this optimal method are unknown. To study neural basis DBS in we used novel, implantable system with long-term local field potential sensing capability. We focus our analysis on two who experienced severe treatment-resistant symptoms were implanted systems. them year at...
Abstract Background Whether structural alterations underpin apathy and depression in de novo parkinsonian patients is unknown. The objectives of this study were to investigate whether are related how abnormalities relate serotonergic or dopaminergic dysfunction. Methods We compared the morphological microstructural architecture gray matter using voxel‐based morphometry diffusion tensor imaging coupled with white tract‐based spatial statistics a multimodal case‐control enrolling 14 apathetic...
Dopamine replacement therapy in PD has been associated with both behavioral addictions and dopamine addiction.To investigate potential association between l-dopa induced neuropsychiatric fluctuations PD.A cohort of 102 patients suffering from motor complications treatment was prospectively analyzed. We evaluated addiction, addictions, using the Ardouin scale behavior PD.Patients (n = 51) or without did not differ age, disease duration, medication, UPDRS III score during on off drug...
Background Reports on behavioural outcomes after subthalamic nucleus deep brain stimulation in Parkinson’s disease are controversial and limited to short-term data. Long-term observation a large cohort allows better counselling management. Methods To determine whether long-term treatment with induces or reduces impulse control behaviours, neuropsychiatric fluctuations apathy, 69 patients treated prospectively retrospectively assessed using Ardouin Scale of Behavior Disease before 3–10 years...
Objective This study was undertaken to identify preoperative predictive factors of long‐term motor outcome in a large cohort consecutive Parkinson disease (PD) patients with bilateral subthalamic nucleus deep brain stimulation (STN‐DBS). Methods All PD who underwent STN‐DBS at the Grenoble University Hospital (France) from 1993 2015 were evaluated before surgery, 1 year (short‐term), and long term after surgery. available demographic variables, neuroimaging data, clinical characteristics...
Abstract Background Parkinson's disease (PD) is characterized by heterogeneous motor and nonmotor manifestations related to alterations in monoaminergic neurotransmission systems. Nevertheless, the characterization of concomitant dopaminergic serotonergic dysfunction after different durations disease, as well their respective involvement expression severity neuropsychiatric signs, has gained little attention so far. Methods To fill this gap, we conducted a cross‐sectional study combining...
<h3>Background</h3> Subthalamic nucleus deep brain stimulation (STN-DBS) improves motor symptoms of Parkinson9s disease, leading to improvement in health-related quality life (HRQoL). However, an excessive decrease dopaminergic medication can lead a withdrawal syndrome with apathy as the predominant feature. The present study aims assess impact postoperative on HRQoL. <h3>Methods</h3> A cohort 88 patients who underwent STN-DBS was divided into two groups, those were apathetic at 1 year and...
<h3>Background</h3> Impulse control disorders (ICD), including pathological gambling, are common in Parkinson9s disease (PD) and tend to improve after subthalamic (STN) stimulation a marked reduction of dopaminergic medication. In order investigate the effect STN on impulsive decision making, we used Iowa Gambling task (IGT). <h3>Methods</h3> We investigated IGT performance 20 patients with PD before surgery without treatment 24 age-matched controls. All underwent an extensive...
<h3>Background</h3> Pallidal deep brain stimulation (globus pallidus internus (GPi) DBS) is the best therapeutic option for disabling isolated idiopathic (IID) and inherited (INH) dystonia. Acquired dystonia (AD) may also benefit from GPi DBS. Efficacy safety in long-term remained to be established. <h3>Objective</h3> To retrospectively assess clinical outcomes dystonic patients who underwent <h3>Methods</h3> Patients were videotaped assessed preoperatively postoperatively (1-year at last...