A5041629639- Epilepsy research and treatment
- Neurological disorders and treatments
- Genetic Neurodegenerative Diseases
- Neuroscience and Neuropharmacology Research
- Pharmacological Effects and Toxicity Studies
- EEG and Brain-Computer Interfaces
- Botulinum Toxin and Related Neurological Disorders
- Parkinson's Disease Mechanisms and Treatments
- Neurology and Historical Studies
- Psychosomatic Disorders and Their Treatments
- Vagus Nerve Stimulation Research
- Psychoanalysis and Psychopathology Research
- Functional Brain Connectivity Studies
- Glycogen Storage Diseases and Myoclonus
- Mental Health and Psychiatry
- Transcranial Magnetic Stimulation Studies
- Face Recognition and Perception
- Neurological and metabolic disorders
- Migraine and Headache Studies
- Sleep and Wakefulness Research
- Obsessive-Compulsive Spectrum Disorders
- Neonatal and fetal brain pathology
- Neural dynamics and brain function
- Ion channel regulation and function
- Neural and Behavioral Psychology Studies
Inserm
2015-2025
Université Grenoble Alpes
2016-2025
Centre Hospitalier Universitaire de Grenoble
2016-2025
Centre National de la Recherche Scientifique
2014-2025
Grenoble Institute of Neurosciences
2015-2025
Laboratoire de Psychologie et NeuroCognition
2004-2024
Université Savoie Mont Blanc
2024
Hôpital Nord
2005-2021
Centre Hospitalier Le Vinatier
2018
Centre de Recherche en Neurosciences de Lyon
2018
Severe forms of dystonia respond poorly to medical treatment. Deep-brain stimulation is a reversible neurosurgical procedure that has been used for the treatment dystonia, but assessment its efficacy limited open studies.We performed prospective, controlled, multicenter study assessing and safety bilateral pallidal in 22 patients with primary generalized dystonia. The severity was evaluated before surgery 3, 6, 12 months postoperatively during neurostimulation, use movement disability...
Abstract The vagus nerve ( VN ) is a link between the brain and gut. mixed with anti‐inflammatory properties through activation of hypothalamic–pituitary–adrenal axis by its afferents activating cholinergic pathway efferents. We have previously shown that stimulation VNS improves colitis in rats vagal tone blunted Crohn's disease CD patients. thus performed pilot study chronic patients active . Seven under were followed up for 6 months primary endpoint to induce clinical remission secondary...
Abstract Background The vagus nerve has anti‐inflammatory properties. We aimed to investigate stimulation (VNS) as a new therapeutic strategy targeting an intrinsic pathway in pilot study Crohn's disease patients. main objectives addressed the questions of long‐term safety, tolerability, and effects this therapy. This is continuation previous reported findings at 6 months. Methods Nine patients with moderate active underwent VNS. An electrode wrapped around left cervical was continuously...
<h3>Objective:</h3> To identify the clinical determinants of occurrence postictal generalized EEG suppression (PGES) after convulsive seizures (GCS). <h3>Methods:</h3> We reviewed video-EEG recordings 417 patients included in REPO<sub>2</sub>MSE study, a multicenter prospective cohort study with drug-resistant focal epilepsy. According to ictal semiology, we classified GCS into 3 types: tonic-clonic bilateral and symmetric tonic arm extension (type 1), clonic without or flexion 2),...
Early onset epileptic encephalopathies (EOEEs) are dramatic heterogeneous conditions in which aetiology, seizures and/or interictal EEG have a negative impact on neurological development. Several genes been associated with EOEE and molecular diagnosis workup is challenging since similar phenotypes mutations different one given gene can be very phenotypes. Recently, de novo KCNQ2, found about 10% of patients. Our objective was to confirm that KCNQ2 an important include the EOEEs fully...
Abstract Recent research suggests that autistic females may have superior socio-cognitive abilities compared to males, potentially contributing underdiagnosis in females. However, it remains unclear whether these differences arise from distinct neurophysiological functioning males and This study addresses this question by presenting 41 48 non-autistic adults with a spatially filtered faces oddball paradigm. Analysis of event-related potentials scalp electroencephalography reveal profile fell...
<b>Objective: </b> To assess the effects of bilateral pallidal deep brain stimulation (DBS) on mood and cognitive performance in patients with dystonia before surgery (at baseline, while received their usual treatment) 12 months postoperatively (while neurostimulation medications) a multicenter prospective study. <b>Methods: Twenty-two primary generalized were evaluated tests focused executive functions. The authors considered patients9 severe disability selected following tests: Raven...
<h3>Background</h3> Pallidal deep brain stimulation (globus pallidus internus (GPi) DBS) is the best therapeutic option for disabling isolated idiopathic (IID) and inherited (INH) dystonia. Acquired dystonia (AD) may also benefit from GPi DBS. Efficacy safety in long-term remained to be established. <h3>Objective</h3> To retrospectively assess clinical outcomes dystonic patients who underwent <h3>Methods</h3> Patients were videotaped assessed preoperatively postoperatively (1-year at last...
<h3>Objective</h3> To analyze the factors that determine occurrence or severity of postictal hypoxemia in immediate aftermath a generalized convulsive seizure (GCS). <h3>Methods</h3> We reviewed video-EEG recordings 1,006 patients with drug-resistant focal epilepsy included REPO<sub>2</sub>MSE study to identify those ≥1 GCS and pulse oximetry (SpO<sub>2</sub>) measurement. Factors determining recovery SpO<sub>2</sub> ≥ 90% were investigated using Cox proportional hazards models. Association...
<b>Background:</b> Myoclonus dystonia syndrome (MDS) is an autosomal dominant movement disorder caused by mutations in the epsilon-sarcoglycan gene (<i>SGCE</i>) on chromosome 7q21. <b>Methods:</b> We have screened for <i>SGCE</i> index cases from 76 French patients with myoclonic syndromes, including myoclonus (M-D), essential (E-M), primary dystonia, generalised tremor, and benign hereditary chorea. All coding exons of were analysed. The <i>DYT1</i> mutation was also tested....
Background: Dystonia syndromes constitute a heterogeneous group of phenotypes that may be caused by different heredodegenerative, metabolic, or genetic diseases.
The multicenter SPIDY trial (pallidal stimulation for generalized, idiopathic dystonia) recently reported a marked improvement in dystonia which was assessed by the Burke-Fahn-Marsden (BFM) scale. However, reliability of this tool has rarely been evaluated and its use study never prospectively.To evaluate concordance between three unblinded clinical raters one single-blinded rater 10 prospective series ratings on BFM scale 22 dystonic patients study.Ten assessments were performed under...