Nicolas Carrière
A5003412088- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Advanced Neuroimaging Techniques and Applications
- Botulinum Toxin and Related Neurological Disorders
- Functional Brain Connectivity Studies
- Health, Medicine and Society
- Neurological diseases and metabolism
- EEG and Brain-Computer Interfaces
- Autism Spectrum Disorder Research
- Restless Legs Syndrome Research
- Advanced MRI Techniques and Applications
- Dysphagia Assessment and Management
- Nuclear Receptors and Signaling
- Genomics and Rare Diseases
- Ginkgo biloba and Cashew Applications
- Ophthalmology and Eye Disorders
- Cerebral Venous Sinus Thrombosis
- Genetics and Neurodevelopmental Disorders
- Trace Elements in Health
- Thyroid and Parathyroid Surgery
- Neural dynamics and brain function
- Patient-Provider Communication in Healthcare
- Infectious Encephalopathies and Encephalitis
- Meta-analysis and systematic reviews
- Neuroscience and Neural Engineering
Université de Lille
2016-2024
Inserm
2016-2024
Centre Hospitalier Universitaire de Lille
2015-2024
French Clinical Research Infrastructure Network
2023-2024
Lille Neurosciences & Cognition
2021-2024
Research Network (United States)
2024
Université de Bordeaux
2024
Lille’s Cardiology Hospital
2024
Hôpital Roger Salengro
2011-2022
Institut Pasteur de Lille
2022
BackgroundLixisenatide, a glucagon-like peptide-1 receptor agonist used for the treatment of diabetes, has shown neuroprotective properties in mouse model Parkinson's disease.MethodsIn this phase 2, double-blind, randomized, placebo-controlled trial, we assessed effect lixisenatide on progression motor disability persons with disease. Participants whom disease was diagnosed less than 3 years earlier, who were receiving stable dose medications to treat symptoms, and did not have complications...
Apathy is characterized by lack of interest, loss initiative, and flattening affect. It a frequent, very disabling nonmotor complication Parkinson's disease (PD). The condition may notably occur when dopaminergic medications are tapered after the initiation subthalamic stimulation thus can be referred to as "dopaminergic apathy." Even in absence tapering, some patients develop form apathy PD progresses. This often related cognitive decline does not respond (dopa-resistant apathy). We aimed...
To compare the striatum's resting-state functional connectivity in patients with Parkinson disease (PD) and without impulse control disorders (ICDs).Twenty PD ICDs, 19 but no healthy controls underwent fMRI resting state. The ventral striatum, dorsal caudate, anterior posterior putamen were segmented semiautomatically. For each region of interest, a seed-based analysis was performed on preprocessed data mapped ipsilateral cortical surface. An additional thickness used to assess gray matter...
Introduction Magnetic resonance imaging (MRI) can be used to identify biomarkers in Parkinson's disease (PD); R2* values reflect iron content related high levels of oxidative stress, whereas volume and/or shape changes neuronal death. We sought assess overload the nigrostriatal system and characterize its relationship with focal overall atrophy striatum pivotal stages PD. Methods Twenty controls 70 PD patients at different (untreated de novo patients, treated early-stage advanced-stage...
Primary familial brain calcification (PFBC) is a rare neurogenetic disorder with diverse neuropsychiatric expression. Mutations in four genes cause autosomal dominant PFBC: SLC20A2, XPR1, PDGFB and PDGFRB. Recently, biallelic mutations the MYORG gene have been reported to PFBC an recessive pattern of inheritance. We screened 29 unrelated probands negatively for identified 11 families or novel predicted damaging variant. studied clinical radiological features 16 patients these compared them...
Background: Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is a preferred treatment for parkinsonian patients with severe motor fluctuations. Proper targeting STN sensorimotor segment appears to be crucial factor success procedure. The recent introduction directional leads theoretically increases specificity in this challenging area but also requires more precise parameters. Objective: We investigated whether commercially available software image guided programming (IGP) could...
Abstract Stereotactic radiosurgery (SRS) is one of the surgical alternatives for drug-resistant essential tremor (ET). Here, we aimed at evaluating whether biologically effective dose (BED Gy2.47 ) relevant improvement after stereotactic radiosurgical thalamotomy in a population patients treated with (unplugged) isocenter and uniform 130 Gy. This retrospective longitudinal single center study. Seventy-eight consecutive were clinically analyzed. Mean age was 69.1 years (median 71, range...
There is a growing need for surrogate biomarkers Parkinson's disease (PD). Structural analysis using magnetic resonance imaging with T1-weighted sequences has the potential to quantify histopathological changes. Degeneration typically measured by volume and shape of morphological However, these changes appear late in disease, preventing their use as markers. We investigated texture 108 individuals, divided into three groups, matched terms sex age: (1) healthy controls (n = 32); (2) patients...
Abstract Background Acting on the main target of dopaminergic cells, striatal γ‐aminobutyric acid (GABA)‐ergic might be a new way to treat persons with Parkinson's disease (PD). Objective The objective this study was assess efficacy bumetanide, an Na–K–Cl cotransporter (NKCC1) inhibitor, improve motor symptoms in PD. Methods This 4‐month double‐blind, randomized, parallel‐group, placebo‐controlled trial 1.75 3 mg/day bumetanide as adjunct levodopa 44 participants PD and fluctuations. Results...
People with Parkinson's disease (PwPD) exhibit various sexual difficulties (SDs) that may be due to motor and/or nonmotor symptoms or the use of antiparkinsonian medication. SDs are often underreported by PwPD and underexplored physicians.
Abstract Thousands of papers using resting-state functional magnetic resonance imaging (RS-fMRI) have been published on brain disorders. Results in each paper may survived correction for multiple comparison. However, since there no robust results from large scale meta-analysis, we do not know how many are truly positives. The present meta-analytic work included 60 original studies, with 57 studies (4 datasets, 2266 participants) that used a between-group design and 3 (1 dataset, 107 employed...
Background: Typical presentation of spontaneous internal carotid artery (ICA) dissection is an ipsilateral pain in neck and face with Horner's syndrome contralateral deficits. Although rare, lower cranial nerve palsy have been reported association ICA dissection. Case studies: We report three new cases palsies. Results: The first symtom to appear was headache all patients. Examination disclosed a two (1 2), isolated XIIth patients (case 1 3) IX, X, palsies 2) revealing dissection, confirmed...
Several postmortem studies have shown iron accumulation in the substantia nigra of Parkinson's disease patients. Iron concentration can be estimated via MRI-R2∗ mapping. To assess changes R2∗ occurring patients compared to controls, a multicentre transversal study was carried out on large cohort (n = 163) with matched controls 82). In this study, 44 and 11 were removed due motion artefacts, 21 patient 6 preserve matching. Thus, 98 65 age sex-matched healthy subjects selected enough image...
Abstract Background and purpose The monogenic forms of Parkinson's disease represent <10% familial cases a still lower frequency sporadic cases. However, guidelines to orient genetic testing are lacking. aim was establish the interest multiplex ligation‐dependent probe amplification (MLPA) as primary screening test propose clinical criteria guide diagnostic tests for patients with suspected Mendelian disease. Methods In all, 567 parkinsonism from 547 unrelated families were recruited two...
Impulse control disorders (ICDs) in Parkinson's disease (PD) are related to treatment with dopamine agonists, which is thought deregulate the dopaminergic mesolimbic pathway and impair reward evaluation. EEG studies healthy controls (HCs) have suggested that increase theta power observed after negative outcome a marker of processing.To compare outcome-locked, event-related spectral perturbation gambling task PD patients without ICDs HCs.Twelve ICDs, 12 14 HCs underwent while performing task....