A5026713530- Obsessive-Compulsive Spectrum Disorders
- Autism Spectrum Disorder Research
- Carcinogens and Genotoxicity Assessment
- Intracranial Aneurysms: Treatment and Complications
- Vascular Malformations Diagnosis and Treatment
- Acute Ischemic Stroke Management
- Intracerebral and Subarachnoid Hemorrhage Research
- Effects and risks of endocrine disrupting chemicals
- Cardiac Imaging and Diagnostics
- Cerebrovascular and Carotid Artery Diseases
- German Literature and Culture Studies
- Eating Disorders and Behaviors
- Transplantation: Methods and Outcomes
- Animal testing and alternatives
- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Advanced Neuroimaging Techniques and Applications
- Cardiovascular Function and Risk Factors
- Coronary Interventions and Diagnostics
- Advanced Harmonic Analysis Research
- Acute Myocardial Infarction Research
- Botulinum Toxin and Related Neurological Disorders
- Nitric Oxide and Endothelin Effects
- DNA Repair Mechanisms
- Holomorphic and Operator Theory
Novartis (Switzerland)
2015-2025
Leipzig University of Applied Sciences
2023-2025
Novartis Institutes for BioMedical Research
2015-2025
Sorbonne Université
2015-2024
Assistance Publique – Hôpitaux de Paris
2015-2024
Pitié-Salpêtrière Hospital
2015-2024
Institut du Cerveau
2012-2024
Inserm
2013-2023
Centre National de la Recherche Scientifique
2013-2023
Institut de Mathématiques de Bordeaux
2001-2023
Atthe International Workshop on Genotoxicity Test Procedures (IWGTP) held in Washington, DC, March 25-26, 1999, an expert panel met to develop guidelines for the use of single-cell gel (SCG)/Comet assay genetic toxicology. The reached a consensus that optimal version Comet identifying agents with genotoxic activity was alkaline (pH > 13) developed by Singh et al. [1988]. pH 13 is capable detecting DNA single-strand breaks (SSB), alkali-labile sites (ALS), DNA-DNA/DNA-protein cross-linking,...
The in vivo alkaline single cell gel electrophoresis assay, hereafter the Comet can be used to investigate genotoxicity of industrial chemicals, biocides, agrochemicals and pharmaceuticals. major advantages this assay include relative ease application any tissue interest, detection multiple classes DNA damage generation data at level cell. These features give potential over other test methods, which are limited largely proliferating cells and/or a tissue. has demonstrated its reliability...
Time to thrombolysis is crucial for outcome in acute ischemic stroke.To determine if starting a specialized ambulance reduces delays.In the Prehospital Acute Neurological Treatment and Optimization of Medical care Stroke Study (PHANTOM-S), conducted Berlin, Germany, we randomly assigned weeks with without availability Emergency Mobile (STEMO) from May 1, 2011, January 31, 2013. Berlin has an established stroke infrastructure 14 units. We included 6182 adult patients (STEMO weeks: 44.3% male,...
A working group of the European Society for Study Tourette Syndrome (ESSTS) has developed first assessment guidelines (TS). The available literature including national was thoroughly screened and extensively discussed in expert ESSTS members. Detailed clinical tic disorders their comorbidities both children adults are presented. Screening methods that might be helpful necessary specialists' differential diagnosis process suggested order to further analyse cognitive abilities, emotional...
Gilles de la Tourette syndrome is a childhood-onset characterized by the presence and persistence of motor vocal tics. A dysfunction cortico-striato-pallido-thalamo-cortical networks in this has been supported convergent data from neuro-pathological, electrophysiological as well structural functional neuroimaging studies. Here, we addressed question integration syndrome. We specifically tested hypothesis that deviant brain development could affect connectivity within input output basal...
<h3>Importance</h3> Effects of thrombolysis in acute ischemic stroke are time-dependent. Ambulances that can administer (mobile units [MSUs]) before arriving at the hospital have been shown to reduce time treatment. <h3>Objective</h3> To determine whether dispatch MSUs is associated with better clinical outcomes for patients stroke. <h3>Design, Setting, and Participants</h3> This prospective, nonrandomized, controlled intervention study was conducted Berlin, Germany, from February 1, 2017,...
Little is known about the neuronal substrates of neuropsychiatric symptoms associated with COVID-19 and their evolution during course disease. We aimed at describing longitudinal brain metabolic pattern in COVID-19-related encephalopathy using 18F-FDG-PET/CT.Seven patients variable clinical presentations were explored thrice 18F-FDG-PET/CT, once acute phase, 1 month later 6 months after onset. PET images analysed voxel-wise regions-of-interest approaches comparison 32 healthy...
Abstract Part II of the European clinical guidelines for Tourette syndrome and other tic disorders (ECAP journal, 2011) provides updated information recommendations psychological interventions individuals with disorders, created by a working group Society Study Syndrome (ESSTS). A systematic literature search was conducted to obtain original studies published since initial were issued. Relevant identified using computerized searches MEDLINE PsycINFO databases years 2011–2019 manual...
Background and Purpose —The purpose of this study was to assess demographic, clinical, morphological characteristics patients with brain arteriovenous malformations (AVMs). Methods —Prospectively collected data 1289 consecutive AVM from 3 independent databases (1 multicenter [Berlin/Paris/Middle Far East, n=662] 2 single centers [New York, n=337, Toronto, n=290]) were analyzed. The variables assessed age at diagnosis, sex, size, drainage pattern, location in functionally important areas...
Oxidative stress is thought to be involved in the mechanism of nerve cell death Parkinson’s disease (PD). Among several toxic oxidative species, nitric oxide (NO) has been proposed as a key element on basis increased density glial cells expressing inducible synthase (iNOS) substantia nigra (SN) patients with PD. However, iNOS induction CNS poorly understood, especially under pathological conditions. Because cytokines and FcεRII/CD23 antigen have implicated immune system, we investigated...
The comet assay or single-cell gel (SCG) test is becoming established as a useful technique for studying DNA damage and repair. In this microgel electrophoresis technique, small number of cells suspended in thin agarose on microscope slide lysed, electrophoresed, stained with fluorescent binding dye. Cells increased display migration chromosomal from the nucleus toward anode, which resembles shape (Fig. 1). its alkaline version, mainly used, strand breaks alkali-labile sites become apparent,...
Purpose —The purpose of this study was to define the influence feeding mean arterial pressure (FMAP) in conjunction with other morphological or clinical risk factors determining probability hemorrhagic presentation patients cerebral arteriovenous malformations (AVMs). Methods —Clinical and angiographic data from 340 AVMs a prospective database were reviewed. Patients identified whom FMAP measured during superselective angiography. Additional variables analyzed included AVM size, location,...