A5045090838- Acute Ischemic Stroke Management
- Traumatic Brain Injury and Neurovascular Disturbances
- Stroke Rehabilitation and Recovery
- Health Systems, Economic Evaluations, Quality of Life
- Venous Thromboembolism Diagnosis and Management
- Intracerebral and Subarachnoid Hemorrhage Research
- Clinical practice guidelines implementation
- Patient-Provider Communication in Healthcare
- Blood Pressure and Hypertension Studies
- Trauma and Emergency Care Studies
- Hemispheric Asymmetry in Neuroscience
- Cardiac Health and Mental Health
Berlin Institute of Health at Charité - Universitätsmedizin Berlin
2023-2025
Charité - Universitätsmedizin Berlin
2019-2023
Hudson Institute
2023
Liechtenstein Institute
2023
Humboldt-Universität zu Berlin
2022-2023
Freie Universität Berlin
2022-2023
John Wiley & Sons (United States)
2023
<h3>Importance</h3> Effects of thrombolysis in acute ischemic stroke are time-dependent. Ambulances that can administer (mobile units [MSUs]) before arriving at the hospital have been shown to reduce time treatment. <h3>Objective</h3> To determine whether dispatch MSUs is associated with better clinical outcomes for patients stroke. <h3>Design, Setting, and Participants</h3> This prospective, nonrandomized, controlled intervention study was conducted Berlin, Germany, from February 1, 2017,...
Background Lower global disability and higher quality of life among ischemic stroke patients was found to be associated with the dispatch mobile units (MSUs) eligible for recanalizing treatments in Berlin_Prehospital Or Usual Delivery care (B_PROUD) study. The current study assessed cost‐utility cost‐effectiveness additional MSU using data from this prospective, controlled, intervention Methods Outcomes considered economic evaluation included quality‐adjusted years (QALYs) derived 3‐level...
Background: Intravenous thrombolysis (IVT) is not approved for acute ischemic stroke in certain patient groups due to in- and exclusion criteria from mostly early clinical trials. In a real-life setting, we analyzed frequencies, outcomes complications of off-label-IVT compared on-label-IVT no IVT contribute rational decision-making regarding selection IVT. Methods: Patients the Berlin Specific Acute Therapy Ischemic or hAemorrhagic with Long-term follow-up registry were divided into three...
Introduction: In patients with acute intracerebral haemorrhage (ICH) and elevated systolic blood pressure (BP), guidelines suggest that BP reduction to <140 mmHg should be rapidly initiated. Compared conventional care, Mobile Stroke Units (MSUs) allow for earlier ICH diagnosis through prehospital imaging lowering. Patients methods: were prospectively evaluated as a cohort of the controlled B_PROUD-study in which MSU availability alone determined dispatch addition ambulance. We used...
To determine the effect of additional mobile stroke unit (MSU) dispatch on functional outcomes among full spectrum patients, regardless subtype or potential contraindications to reperfusion therapies.We used data from nonrandomized Berlin-based B_PROUD study (02/2017 05/2019), in which MSUs were dispatched based solely availability, and linked B-SPATIAL registry. All patients with final transient ischemic attack (TIA) diagnoses eligible. The intervention under was an MSU, emergency...
Abstract Background Health-related quality of life (HRQL) has become an important outcome parameter in cardiology. The MOS 36-ltem Short-Form Health Survey (SF-36) and the PROMIS-29 are two widely used generic measures providing composite HRQL scores. domains SF-36, a well-established instrument utilized for several decades, can be aggregated to physical (PCS) mental (MCS) component summary Alternative scoring algorithms correlated scores (PCS c MCS ) have also been suggested. is newer but...
Restricting follow-up assessment of both interventional and observational studies to patients who provide informed consent introduces relevant selection bias-particularly by underrepresenting with neurologic communication deficits impaired capacity consent. Many are initially unable give may be willing do so after recovery. Informing on study purposes procedures offering them the option nonparticipation but not requesting explicit is called "opt-out" approach. We investigated whether an...
Studies investigating the Mobile Stroke Unit (MSU) concept have shown increased thrombolysis rates, reduced alarm-to-treatment times and improved prehospital triage. Yet, so far, there is no definite scientific proof of better functional outcome after MSU deployment compared to regular ambulances.We provide a revised protocol for second part B_PROUD trial as organization dispatch did not meet anticipated standards in first part. pragmatic, prospective study comparing outcomes treatment...