A5012841973- Adipose Tissue and Metabolism
- Lipid metabolism and biosynthesis
- Hormonal Regulation and Hypertension
- Cardiovascular Function and Risk Factors
- Ion Transport and Channel Regulation
- Mitochondrial Function and Pathology
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Cardiovascular Effects of Exercise
- Sirtuins and Resveratrol in Medicine
- PARP inhibition in cancer therapy
- Autophagy in Disease and Therapy
- Health Systems, Economic Evaluations, Quality of Life
- RNA modifications and cancer
- ATP Synthase and ATPases Research
- Cancer-related Molecular Pathways
- Cardiovascular Disease and Adiposity
- Advanced MRI Techniques and Applications
- Eicosanoids and Hypertension Pharmacology
- Sarcoma Diagnosis and Treatment
- Metabolomics and Mass Spectrometry Studies
- Neurobiology and Insect Physiology Research
- Lipoproteins and Cardiovascular Health
- Cardiac Health and Mental Health
- Cholesterol and Lipid Metabolism
- Pancreatic function and diabetes
Berlin Institute of Health at Charité - Universitätsmedizin Berlin
2024
Discovery Institute
2021
Sanford Burnham Prebys Medical Discovery Institute
2021
Charité - Universitätsmedizin Berlin
2015-2021
Humboldt-Universität zu Berlin
2018-2021
German Centre for Cardiovascular Research
2016-2021
Freie Universität Berlin
2016-2021
Deutsches Herzzentrum der Charité
2018
PamGene (Netherlands)
2018
Bayer (Germany)
2016-2018
Mineralocorticoid receptor antagonists (MRAs) reduce morbidity and mortality in chronic heart failure. Novel nonsteroidal MRAs are currently developed need to be pharmacologically characterized comparison classical steroidal MRAs. A mouse model of cardiac fibrosis induced by short-term isoproterenol injection was used compare the MRA finerenone eplerenone equi-efficient systemic MR blocking dosages. Molecular mechanisms were studied MR-expressing H9C2/MR+ cardiomyocytes transcriptional...
Pharmacological blockade of mineralocorticoid receptors (MR) is known as an efficacious therapy in chronic heart failure. Therapy with steroidal MR antagonists such spironolactone or eplerenone (EPL) often limited because side effects. Recently, a new highly selective and potent, nonsteroidal antagonist, finerenone (FIN), has been developed. To investigate the effects FIN on pressure-induced cardiac hypertrophy, transverse aortic constriction (TAC) model was used C57BL/6 mice treated (10...
Endurance exercise training induces substantial adaptive cardiac modifications such as left ventricular hypertrophy (LVH). Simultaneously to the development of LVH, adipose tissue (AT) lipolysis becomes elevated upon endurance cope with enhanced energy demands. In this study, we investigated impact on exercise-induced hypertrophy. Mice deficient for triglyceride lipase (Atgl) in AT (atATGL-KO) were challenged chronic treadmill running. Exercise-induced lipolytic activity was significantly...
Adipose tissue lipolysis occurs during the development of heart failure as a consequence chronic adrenergic stimulation. However, impact enhanced adipose triacylglycerol hydrolysis mediated by triglyceride lipase (ATGL) on cardiac function is unclear. To investigate role failure, we generated mice with tissue-specific deletion ATGL (atATGL-KO). atATGL-KO were subjected to transverse aortic constriction (TAC) induce pressure-mediated failure. The mouse lipidome and human plasma from healthy...
The assessment of ventricular volumes using conventional echocardiography methods is limited with regards to the need geometrical assumptions. In present study, we aimed evaluate a novel commercial system for three-dimensional (3DE) in preclinical models by direct comparison 1D- and 2D-echocardiography (1DE; 2DE) gold-standard technique magnetic resonance imaging (MRI). Further, provide standard operating protocol image acquisition analysis 3DE. 3DE was carried out 30 MHz center frequency...
The cross talk between adipose tissue and the heart has an increasing importance for cardiac function under physiological pathological conditions. This study characterizes role of fat body lipolysis in Drosophila melanogaster. Perturbation key lipolytic enzyme, brummer (bmm), ortholog mammalian ATGL (adipose triglyceride lipase) exclusively fly's body, protected against starvation-induced dysfunction. We further provide evidence that this protection is caused by preservation glycerolipid...
Abstract Background Health-related quality of life (HRQL) has become an important outcome parameter in cardiology. The MOS 36-ltem Short-Form Health Survey (SF-36) and the PROMIS-29 are two widely used generic measures providing composite HRQL scores. domains SF-36, a well-established instrument utilized for several decades, can be aggregated to physical (PCS) mental (MCS) component summary Alternative scoring algorithms correlated scores (PCS c MCS ) have also been suggested. is newer but...
Cardiolipin (CL) is a major cardiac mitochondrial phospholipid maintaining regular morphology and function in cardiomyocytes. Cardiac CL production includes its biosynthesis remodeling process. Here we studied the impact of enzyme cardiolipin synthase (CLS) on function. CLS species were significantly downregulated cardiomyocytes following catecholamine-induced damage mice, accompanied by increased oxygen consumption rates, signs oxidative stress, uncoupling. RNAi-mediated...
Background It is known that dietary intake of polyunsaturated fatty acids may improve cardiac function. However, relatively high daily doses are required to achieve sufficient concentrations beneficial omega-3 acids. The liver X receptor (LXR) a nuclear hormone and crucial regulator lipid homeostasis in mammals. LXR activation has been shown endogenously reprogram cellular profiles toward increased levels. Here we studied whether reprogramming occurs tissue exerts cardioprotective actions....