A5027602672- Acute Ischemic Stroke Management
- Stroke Rehabilitation and Recovery
- Traumatic Brain Injury and Neurovascular Disturbances
- Venous Thromboembolism Diagnosis and Management
- Radiation Detection and Scintillator Technologies
- Mass Spectrometry Techniques and Applications
- Trauma and Emergency Care Studies
- Topic Modeling
- Ion-surface interactions and analysis
- Explainable Artificial Intelligence (XAI)
- Quantum Dots Synthesis And Properties
- Neuroinflammation and Neurodegeneration Mechanisms
- Respiratory Support and Mechanisms
- Cerebrovascular and Carotid Artery Diseases
- Cardiac Arrest and Resuscitation
- Atmospheric chemistry and aerosols
- Copper-based nanomaterials and applications
- Neurological Disorders and Treatments
- Natural Language Processing Techniques
- Chalcogenide Semiconductor Thin Films
- Advanced Photocatalysis Techniques
- Particle Detector Development and Performance
- Spectroscopy and Quantum Chemical Studies
- Pleural and Pulmonary Diseases
- Tracheal and airway disorders
Forschungszentrum Jülich
2022-2024
University of Illinois Chicago
2023
Technische Universität Braunschweig
2021
St. Josef Krankenhaus
2018-2021
Berliner Hochschule für Technik
2019-2020
University of Oxford
2012-2020
Universität Ulm
2020
Charité - Universitätsmedizin Berlin
2003-2019
University of Arkansas for Medical Sciences
2017
German Center for Neurodegenerative Diseases
2016-2017
Time to thrombolysis is crucial for outcome in acute ischemic stroke.To determine if starting a specialized ambulance reduces delays.In the Prehospital Acute Neurological Treatment and Optimization of Medical care Stroke Study (PHANTOM-S), conducted Berlin, Germany, we randomly assigned weeks with without availability Emergency Mobile (STEMO) from May 1, 2011, January 31, 2013. Berlin has an established stroke infrastructure 14 units. We included 6182 adult patients (STEMO weeks: 44.3% male,...
A scalable, hysteresis-free and planar architecture perovskite solar cell is presented, employing a flame spray synthesized low-temperature processed NiO (LT-NiO) as hole-transporting layer yielding efficiencies close to 18%. Importantly, it found that LT-NiO boosts the limits of open-circuit voltages toward an impressive non-radiative voltage loss 0.226 V only, whereasPSS suffers from significant large recombination losses.
Physical activity upregulates endothelial nitric oxide synthase (eNOS), improves endothelium function, and protects from vascular disease. Here, we tested whether voluntary running would enhance neovascularization long-term recovery following mild brain ischemia. Wild-type mice were exposed to 30 minutes of middle-cerebral artery occlusion (MCAo) reperfusion. Continuous on wheels conferred upregulation eNOS in the vasculature progenitor cells (EPCs) spleen bone marrow (BM). This was...
<h3>Importance</h3> The effectiveness of intravenous thrombolysis in acute ischemic stroke is time dependent. effects are likely to be highest if the from symptom onset treatment within 60 minutes, termed the<i>golden hour</i>. <h3>Objective</h3> To determine achievable rate golden hour prehospital care and its effect on outcome. <h3>Design, Setting, Participants</h3> prospective controlled Prehospital Acute Neurological Treatment Optimization Medical Care Stroke study was conducted Berlin,...
Beneficial effects of IV tissue plasminogen activator (tPA) in acute ischemic stroke are strongly time-dependent. In the Pre-Hospital Acute Neurological Treatment and Optimization Medical care Stroke (PHANTOM-S) study, we undertook treatment using a specialized ambulance, emergency mobile unit (STEMO), to shorten call-to-treatment time.The ambulance was staffed with neurologist, paramedic, radiographer equipped CT scanner, point-of-care laboratory, teleradiology system. It deployed by...
A facile one‐pot synthesis of hybrid materials consisting PbSe quantum dots (QDs) that grow epitaxially on MoS 2 nanoflakes resulting in three equivalent orientation variants the QDs with respect to lattice is demonstrated. The epitaxial growth and cross‐sectional high‐resolution transmission electron microscopy (HRTEM) investigations verify a direct linker‐free contact between transition metal dichalcogenide (TMD) nanoflakes, while maintaining surface passivation oleic acid ligands outside....
Abstract Temporal delay in blood oxygenation level–dependent (BOLD) signals may be sensitive to perfusion deficits acute stroke. Resting‐state functional magnetic resonance imaging (rsfMRI) was added a standard stroke MRI protocol. We calculated the time between BOLD signal at each voxel and whole‐brain using time‐lagged correlation compared results mean transit derived bolus tracking. In all 11 patients, areas exhibiting significant corresponded of hypoperfusion identified by contrast‐based...
Zeolite crystals with an embedded and interconnected macropore system are prepared by using mesoporous silica particles as a source sacrificial macroporogen. These novel hierarchical zeolite expected to reduce diffusion limitations in all zeolite-catalyzed reactions, especially the transformation of larger molecules like catalytic cracking polymers conversion biomass. As service our authors readers, this journal provides supporting information supplied authors. Such materials peer reviewed...
Specialized management of patients with stroke is not available in all hospitals. We evaluated whether prehospital the Stroke Emergency Mobile (STEMO) improves triage stroke.STEMO an ambulance staffed a specialized team and equipped computed tomographic scanner point-of-care laboratory. compared suspected at dispatcher level who either received STEMO care or conventional care. assessed transport destination different diagnoses. Status hospital discharge was used as short-term outcome.From...
Abstract The high‐pressure hydrogenation of commercially available anatase or anatase/rutile TiO 2 powder can create a photocatalyst for H evolution that is highly effective and stable without the need any additional co‐catalyst. This activation effect cannot be observed rutile; however, mixtures, strong synergistic found (similar to results commonly noble‐metal‐decorated ). EPR PL measurements indicated intrinsic co‐catalytic due specific defect centers formed during hydrogenation. These...
Histone H3 methylation at Lys27 (H3K27 methylation) is a hallmark of silent chromatin, while H3K4 associated with active chromatin regions. Here we report that Drosophila JmjC family member, dUTX, specifically demethylates di- and trimethylated but not monomethylated H3K27. dUTX localization on correlates the elongating form RNA polymerase II (Pol II), can associate Pol II. Furthermore, heat shock induction results in recruitment to hsp70 gene, like several other elongation factors. Our data...
Background and Purpose— Pre- intrahospital time delays are major concerns in acute stroke care. Telemedicine-equipped ambulances may improve management identify patients with eligible for thrombolysis by an early prehospital diagnosis. The aims of this study were (1) to develop a telestroke ambulance prototype; (2) test the reliability severity assessment; (3) evaluate its feasibility emergency setting. Methods— Mobil, real-time audio–video streaming telemedicine devices implemented into...
Folate deficiency and resultant increased homocysteine levels have been linked experimentally epidemiologically with neurodegenerative conditions like stroke dementia. Moreover, folate has implicated in the pathogenesis of psychiatric disorders, most notably depression. We hypothesized that pathogenic mechanisms include uracil misincorporation and, therefore, analyzed effects mice lacking DNA glycosylase ( Ung −/−) versus wild-type controls. depletion nuclear mutation rates −/− embryonic...
<h3>Objective</h3> Vascular lesions of the posterolateral thalamus typically result in a somatosensory syndrome which some patients develop central neuropathic post-stroke pain (CPSP). Damage to spinothalamic tract terminus is assumed be prerequisite for thalamic CPSP. At nuclear level, it remains matter debate whether ventral nucleus (VPL) or posterior portion medial (VMpo) constitutes decisive lesion site. The hypothesis study was that location CPSP differs from stroke without pain, and...
The wing scales of the Green Hairstreak butterfly Callophrys rubi consist crystalline domains with sizes a few micrometers, which exhibit congenitally handed porous chitin microstructure identified as chiral triply periodic single-gyroid structure. Here, chirality and crystallographic texture these are investigated by means electron tomography. tomograms unambiguously reveal coexistence two enantiomeric forms opposite handedness: left- right-handed gyroids. These enantiomers appear nonequal...
Bidirectional Encoder Representations from Transformers (BERT) reach state-of-the-art results in a variety of Natural Language Processing tasks. However, understanding their internal functioning is still insufficient and unsatisfactory. In order to better understand BERT other Transformer-based models, we present layer-wise analysis BERT's hidden states. Unlike previous research, which mainly focuses on explaining Transformer models by attention weights, argue that states contain equally...
Rationale Time from symptom onset to treatment is closely associated with the effectiveness of intravenous thrombolysis in acute ischemic stroke patients. Hospitals are encouraged take every effort shorten delay treatment. Despite combined efforts streamline procedures hospitals provide as soon possible, most patients receive tissue plasminogen activator considerable and very few them within 90 mins. Germany has an internationally acknowledged prehospital emergency care system specially...
PImMS, or Pixel Imaging Mass Spectrometry, is a novel high-speed monolithic CMOS imaging sensor tailored to mass spectrometry requirements, also suitable for other dark-field applications. In its application time-of-flight spectrometry, the permits ion arrival time distributions be combined with 2D imaging, providing additional information about initial position velocity of ions under study. PImMS1, first generation in this family, comprises an array 72 by pixels on 70 μm pitch. Pixels...
The development of sensors capable detecting particles and radiation with both high time positional resolution is key to improving our understanding in many areas science. Example applications such range from fundamental scattering studies chemical reaction mechanisms through imaging mass spectrometry surfaces, neutron aimed at probing the structure materials, time-resolved fluorescence measurements elucidate function biomolecules. In addition improved throughput resulting parallelisation...
<b><i>Background:</i></b> Both, acute ischemic stroke (AIS) and hemorrhage (intracerebral hemorrhage, ICH) require early attention but different treatment strategies. Plasma glial fibrillary acidic protein (GFAP) levels were found to be elevated in ICH patients after they arrived the hospital. Because options differed, we sought determine whether GFAP can used accurately differentiate between of AIS prehospital setting. <b><i>Methods:</i></b>...
Background Mobile stroke units ( MSU s), equipped with an integrated computed tomography scanner, can shorten time to thrombolytic treatment and may improve outcome in patients acute ischemic stroke. Original (German) s are staffed by neurologists trained as emergency physicians, but patient assessment decisions a remote neurologist offer alternative aboard . Methods Results Remote examined assessed treated the Berlin, Germany. Audiovisual quality was rated from 1 (excellent) 6...