A5008903735- Acute Ischemic Stroke Management
- Atrial Fibrillation Management and Outcomes
- Cerebrovascular and Carotid Artery Diseases
- Cardiac Arrhythmias and Treatments
- Cardiac electrophysiology and arrhythmias
- Venous Thromboembolism Diagnosis and Management
- Traumatic Brain Injury and Neurovascular Disturbances
- Stroke Rehabilitation and Recovery
- Intracerebral and Subarachnoid Hemorrhage Research
- Antiplatelet Therapy and Cardiovascular Diseases
- Chronic Kidney Disease and Diabetes
- Renal and Vascular Pathologies
- Biomedical Text Mining and Ontologies
- Cardiac Imaging and Diagnostics
- Cardiac Health and Mental Health
- Acute Myocardial Infarction Research
- Neurological disorders and treatments
- Blood Pressure and Hypertension Studies
- Lipoproteins and Cardiovascular Health
- Data Quality and Management
- Parkinson's Disease Mechanisms and Treatments
- Vascular Malformations Diagnosis and Treatment
- Cardiovascular Function and Risk Factors
- Semantic Web and Ontologies
- Heart Failure Treatment and Management
Charité - Universitätsmedizin Berlin
2015-2025
National Hospital for Neurology and Neurosurgery
2014
University College London
2014
University Hospital of Basel
2013
Background and Purpose— The aim of our study was to assess whether statins have dose-dependent effects on risk symptomatic intracerebral hemorrhage (sICH) outcome after intravenous thrombolysis for ischemic stroke. Methods— We pooled data from 2 European registries. Statin doses were stratified in 3 groups according the attainable lowering cholesterol levels (low dose: simvastatin 20 mg or equivalent; medium 40 high 80 equivalent). sICH defined Cooperative Acute Stroke Study. Modified Rankin...
ABSTRACT Aims Atrial fibrillation (AF) accounts for about 20% of all ischemic strokes worldwide. It is known that AF impairs health‐related quality life (HRQOL) in the general population, but data on HRQOL stroke patients with newly diagnosed are sparse. Methods Post hoc analysis prospective, investigator‐initiated, multicenter MonDAFIS study (NCT02204267) to analyze whether AF‐related oral anticoagulation (OAC), and/or AF‐symptom severity associated after or transient attack (TIA). was...
Background Excessive supraventricular ectopic activity (ESVEA) is regarded as a risk marker for later atrial fibrillation (AF) detection. Methods and Results The investigator‐initiated, prospective, open, multicenter MonDAFIS (Impact of Standardized Monitoring Detection Atrial Fibrillation in Ischemic Stroke) study randomized 3465 patients with acute ischemic stroke without known AF 1:1 to usual diagnostic procedures detection or additive Holter monitoring hospital up 7 days, analyzed core...
Patients with renal impairment (RI) have an increased risk of both thrombotic and hemorrhagic events. We aimed to clarify whether RI increases the intracerebral hemorrhage (ICH) after intravenous thrombolysis recombinant tissue plasminogen activator.Patients who received activator within 4.5 hours symptom onset were retrospectively analyzed. Creatinine levels on admission served calculate glomerular filtration rate (GFR) estimate according International Classification Diseases criteria....
Background In patients with acute ischemic stroke, little is known regarding the frequency of abnormal ECG findings other than atrial fibrillation and their association cardiovascular outcomes. We aim to analyze type findings, subsequent changes in medical treatment, outcomes stroke. Methods Results investigator-initiated multicenter MonDAFIS (impact standardized monitoring for detection stroke) study, 3465 stroke or transient attack without were randomized 1:1 receive Holter-ECG up 7 days...
Background and Purpose- Relative signal intensity of acute ischemic stroke lesions in fluid-attenuated inversion recovery (fluid-attenuated relative [FLAIR-rSI]) magnetic resonance imaging is associated with time elapsed since onset higher intensities signifying longer intervals. In the randomized controlled WAKE-UP trial (Efficacy Safety MRI-Based Thrombolysis Wake-Up Stroke Trial), intravenous alteplase was effective patients unknown selected by visual assessment diffusion weighted...
Symptomatic intracranial hemorrhage (sICH) after intravenous thrombolysis with recombinant tissue-plasminogen activator (rt-PA) for acute ischemic stroke is associated a poor functional outcome. We aimed to develop score assessing risk of sICH including novel putative predictors-namely, pretreatment statins and severe renal impairment.We analyzed our local cohort (Berlin) patients receiving rt-PA between 2006 2016. Outcome was according ECASS-III criteria. A multiple regression model...
Background Oral anticoagulation (OAC) is key in stroke prevention patients with atrial fibrillation (AF) but there uncertainty regarding the optimal timing of OAC (re)initiation after stroke, as recent large randomised controlled trials have methodological weaknesses and excluded on therapeutic at onset well started a vitamin K antagonist stroke. The ‘1–3–6–12 days rule’, based expert consensus referring to severity, was used clinical practice initiate acute ischaemic or transient attack...
Data on safety of intravenous thrombolysis with recombinant tissue-type plasminogen activator for acute ischemic stroke in patients coexisting cerebral cavernous malformations (CCMs) are scarce. We assessed the risk thrombolysis-associated hemorrhage these patients.We searched our tertiary care hospital register CCM confirmed by MRI (3 T, Siemens, TimTrio) before stroke. CCMs were graded into subtypes according to Zabramski classification basis their appearance. The primary end point was...
We aimed to analyze prevalence and predictors of NOAC off-label under-dosing in AF patients before after the index stroke.
Abstract Aims The Berlin Atrial Fibrillation Registry was designed to analyse oral anticoagulation (OAC) prescription in patients with atrial fibrillation (AF) and acute ischaemic stroke. Methods results This investigator-initiated prospective multicentre registry enrolled at all 16 stroke units located Berlin, Germany. ongoing telephone follow-up is conducted centrally will cover 5 years per patient. Within 2014 2016, 1080 gave written informed consent 1048 were available for analysis....
Paroxysmal Atrial fibrillation (AF) is often clinically silent and may be missed by the usual diagnostic workup after ischemic stroke. We aimed to determine whether shape characteristics of stroke lesions can used predict AF in patients without known at baseline. Lesion quantification on brain MRI was performed selected from intervention arm Impact standardized MONitoring for Detection Fibrillation Ischemic Stroke (MonDAFIS) study, which included with or TIA prior AF. Multiple morphologic...
Abstract Aims Patients with chronic heart failure (CHF) have an increased risk of ischaemic stroke. We aimed to identify the incidence rate and factors associated stroke or transient attack (TIA) in CHF patients as well impact non‐invasive telemedical care (NITC) on acute stroke/TIA. Methods results retrospectively analysed baseline characteristics 2248 enrolled prospective multicentre Telemedical Interventional Monitoring Heart Failure study (TIM‐HF) Management II (TIM‐HF2), randomizing New...
Abstract Heart failure (HF) is associated with poor outcome after stroke, but data from large prospective trials are sparse. We assessed the impact of HF on clinical endpoints in patients hospitalized acute ischemic stroke or transient attack (TIA) enrolled prospective, multicenter Systematic Monitoring for Detection Atrial Fibrillation Patients Acute Ischemic Stroke (MonDAFIS) trial. was defined as left ventricular ejection fraction (LVEF) < 55% a history admission. The composite...
Abstract Background About 25% of all ischaemic strokes are related to cardio-embolism, most often due atrial fibrillation (AF). Little is known about the extent and standardization routine cardiac diagnostic work-up at certified stroke-units in Germany. Methods The MonDAFIS study included non-AF patients with acute stroke or transient attack (TIA) 38 Here, we analysed disregarded study-related Holter-ECG monitoring. We compared duration stroke-unit stay, number 24-h Holter-ECGs,...