A5043688934- Monoclonal and Polyclonal Antibodies Research
- Neuroscience and Neuropharmacology Research
- T-cell and B-cell Immunology
- Multiple Sclerosis Research Studies
- Historical, Literary, and Cultural Studies
- Semiconductor Quantum Structures and Devices
- German Literature and Culture Studies
- Linguistic research and analysis
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- Neuroinflammation and Neurodegeneration Mechanisms
- Quantum and electron transport phenomena
- Molecular Biology Techniques and Applications
- RNA Research and Splicing
- Protein purification and stability
- Peripheral Neuropathies and Disorders
- Chemical Synthesis and Analysis
- Advanced MRI Techniques and Applications
- Additive Manufacturing and 3D Printing Technologies
- Protein Hydrolysis and Bioactive Peptides
- Cardiac Imaging and Diagnostics
- Stress Responses and Cortisol
- Biochemical and Structural Characterization
- RNA and protein synthesis mechanisms
- Peptidase Inhibition and Analysis
Institute of Evolutionary Physiology and Biochemistry
2019-2024
ETH Zurich
2024
University Medical Center of the Johannes Gutenberg University Mainz
2024
Johannes Gutenberg University Mainz
2024
University of Coimbra
2024
Czech Academy of Sciences, Institute of Experimental Medicine
2022
Pavlov Institute of Physiology of the Russian Academy of Sciences
2022
Charité - Universitätsmedizin Berlin
2022
Universitätsmedizin Göttingen
2010-2021
Institute of Experimental Medicine
2014-2021
A subset of patients with neuromyelitis optica spectrum disorders (NMOSD) has been shown to be seropositive for myelin oligodendrocyte glycoprotein antibodies (MOG-IgG). To describe the epidemiological, clinical, radiological, cerebrospinal fluid (CSF), and electrophysiological features a large cohort MOG-IgG-positive optic neuritis (ON) and/or myelitis (n = 50) as well attack long-term treatment outcomes. Retrospective multicenter study. The sex ratio was 1:2.8 (m:f). Median age at onset 31...
Antibodies to myelin oligodendrocyte glycoprotein (MOG-IgG) have been suggested play a role in subset of patients with neuromyelitis optica and related disorders.To assess (i) the frequency MOG-IgG large predominantly Caucasian cohort optic neuritis (ON) and/or myelitis; (ii) among AQP4-IgG-positive vice versa; (iii) origin cerebrospinal fluid (CSF); (iv) presence at disease onset; (v) influence activity treatment status on titers.614 serum samples from ON myelitis controls, including 92...
Myelin oligodendrocyte glycoprotein antibodies (MOG-IgG) are present in a subset of aquaporin-4 (AQP4)-IgG-negative patients with optic neuritis (ON) and/or myelitis. Little is known so far about brainstem involvement MOG-IgG-positive patients. To investigate the frequency, clinical and paraclinical features, course, outcome, prognostic implications ON Retrospective case study. Among 50 myelitis, 15 (30 %) history encephalitis were identified. All negative for AQP4-IgG. Symptoms included...
Poloxamers are triblock copolymers with a center block of hydrophobic polypropylene oxide (PPO) flanked by two hydrophilic polyethyleneoxide (PEO) blocks. Among this family copolymers, poloxamer 407 is non-ionic surfactant reversible gelation properties above particular polymer concentration and temperature. Easy preparation based sterile injectable formulations have made copolymer good candidate for drug delivery, specifically when controlled release the required. Previously, applications...
Multiple sclerosis (MS) disease risk is associated with reduced sun-exposure. This study assessed the relationship between measures of sun exposure (vitamin D [vitD], latitude) and MS severity in setting two multicenter cohort studies (nNationMS = 946, nBIONAT 990). Additionally, effect-modification by medication photosensitivity-associated MC1R variants was assessed. High serum vitD a score (MSSS), for relapses, lower disability accumulation over time. Low latitude higher vitD, MSSS, fewer...
Linomide (quinoline-3-carboxamide) is a synthetic immunomodulator that increases the natural killer cell activity. We previously demonstrated linomide effectively inhibited clinical and histopathologic signs of acute chronic relapsing experimental autoimmune encephalomyelitis. report double-blind, placebo-controlled study to evaluate tolerability obtain preliminary indications efficacy on secondary progressive MS. Thirty patients suffering from clinically definite laboratory-supported MS,...
Naturally occurring regulatory T (T(reg)) cells are functionally impaired in patients with relapsing-remitting multiple sclerosis. We recently showed that prevalences of newly generated CD31-coexpressing naive T(reg) (recent thymic emigrant-T(reg) cells) critical for suppressive function circulating cells, and a shift the homeostatic composition T(reg)-cell subsets related to reduced de novo generation recent may contribute sclerosis (MS)-related dysfunction. Interferon beta, an...
To assess pediatric patients with multiple sclerosis (MS) for early signs of homeostatic and functional abnormalities in conventional (Tcon) regulatory T cells (Treg).We studied the composition peripheral T-cell compartment Treg function a cross-sectional study 30 MS (pMS) by multicolor flow cytometry proliferation assays. Data were compared to those obtained from adult (n = 26) age-matched control donors 67).Proportions naive 10%-20% higher children than adults, reflecting age-related...
Temporal lobe epilepsy is a widespread chronic disorder that manifests as spontaneous seizures and often characterized by refractoriness to drug treatment. can be caused primary brain injury; therefore, the prevention of epileptogenesis after event considered one best treatment options. However, preventive for still does not exist. Neuroinflammation directly involved in neurodegeneration, leading epileptic condition cognitive decline. In present study, we aimed clarify effect with...
Abstract The suppressor function of regulatory T cells (Tregs) is impaired in multiple sclerosis (MS), but the mechanisms underlying this deficiency are not fully understood. As Tregs counteract sustained elevation intracellular calcium, which indispensable for full activation conventional (Tcons), we hypothesized that interference with pathway might prompt MS-related Treg dysfunction. Using single-cell live imaging, observed rapidly reduce Ca2+ influx and downstream signals Tcons upon cell...
To comparatively assess the B-cell composition in blood and CSF of patients with pediatric-onset multiple sclerosis (pedMS) adult-onset (adMS).In this cross-sectional study, we obtained samples from 25 pedMS (8-18 years) 40 adMS (23-65 specimens 66 controls (1-55 years). By using multicolor flow cytometry, identified naive, transitional, isotype class-switched memory, nonswitched double-negative memory subsets as well plasmablasts (PB) terminally differentiated plasma cells (PC). Flow...
Abstract Treg homeostasis is disturbed in multiple sclerosis (MS). Frequencies of recent thymic emigrant (RTE)‐Treg are reduced and the disparity between RTE‐Treg long‐lived memory coincides with MS‐associated defect, as shown previously. Recent studies demonstrate that IL‐7 stromal lymphopoietin (TSLP) critical for maturation. Therefore, altered signaling through their receptors (IL‐7R, TSLP receptor (TSLPR)), sharing IL‐7Rα‐chain (IL‐7Rα), might contribute to impaired development. Using...
Multiple sclerosis and related disorders: Short report peripheral vascular events in a real-world cohort of multiple patients using Fingolimod,
Genomic plasticity is a mechanism for adaptation to environmental cues such as host responses and antifungal drug pressure in many fungi including the human pathogenic yeast Candida glabrata. In this study we evaluated phenotypic genotypic stability of world-wide used C. glabrata reference strain CBS138/ATCC2001 under laboratory conditions. A set ten lineages wild type genetically modified progenies were obtained from different scientific laboratories, analyzed alterations. Even though...
Reverse transcription followed by quantitative polymerase chain reaction (qRT-PCR) is a powerful and commonly used tool for gene expression analysis. It requires the right choice of stably expressed reference genes accurate normalization. In this work, we aimed to select optimal qRT-PCR normalization within different brain areas during first week following pentylenetetrazole-induced seizures in immature (P20-22) Wistar rats. We have tested stability panel nine housekeeping genes: Actb,...
Background and Purpose Data on safety efficacy of intra-arterial (IA) fibrinolytics as adjunct to mechanical thrombectomy (MT) are sparse.Methods INtra-arterial FIbriNolytics In ThrombectomY (INFINITY) is a retrospective multi-center observational registry consecutive patients with anterior circulation large-vessel occlusion ischemic stroke treated MT adjunctive administration IA (alteplase [tissue plasminogen activator, tPA] or urokinase [UK]) at 10 European centers. Primary outcome was the...
Myelin oligodendrocyte glycoprotein (MOG) immunoglobulin G (IgG)–associated encephalomyelitis (EM) is a rare autoimmune disorder that displays substantial clinicoradiologic overlap with aquaporin-4 (AQP4)-IgG-seropositive neuromyelitis optica spectrum disorders (NMOSD) and classic multiple sclerosis (MS).1–3,e1 The long-term outcome often poor.2,3,e1 Recent evidence suggests many disease-modifying agents approved for the treatment of MS may be ineffective or even harmful in AQP4-IgG-positive...