Michael Rosenkranz
A5003022650- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Intracranial Aneurysms: Treatment and Complications
- Cardiovascular Health and Disease Prevention
- Intracerebral and Subarachnoid Hemorrhage Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Neurosurgical Procedures and Complications
- Atrial Fibrillation Management and Outcomes
- Stroke Rehabilitation and Recovery
- Advanced Neuroimaging Techniques and Applications
- Oropharyngeal Anatomy and Pathologies
- Vascular Malformations Diagnosis and Treatment
- Venous Thromboembolism Diagnosis and Management
- S100 Proteins and Annexins
- COVID-19 and healthcare impacts
- Neurological Disease Mechanisms and Treatments
- Sarcoidosis and Beryllium Toxicity Research
- Cardiac electrophysiology and arrhythmias
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Medical Practices and Rehabilitation
- History and Developments in Astronomy
- Long-Term Effects of COVID-19
- Biomedical and Chemical Research
- Health Systems, Economic Evaluations, Quality of Life
- Astronomy and Astrophysical Research
Albertinen Diakoniewerk
2014-2025
Charité - Universitätsmedizin Berlin
2021-2023
University Hospital Augsburg
2023
Boston Medical Center
2021-2022
Boston University
2021-2022
Saarland University
2022
Universität Hamburg
2009-2021
University Medical Center Hamburg-Eppendorf
2008-2021
Hospital de Clínicas de Porto Alegre
2021
Grady Memorial Hospital
2021
Abstract Objective o evaluate the use of fluid‐attenuated inversion recovery (FLAIR) imaging as surrogate marker lesion age within first 6 hours ischemic stroke. Methods e analyzed FLAIR and diffusion‐weighted (DWI) sequences performed symptom onset in 120 consecutive patients with stroke known onset. The visibility acute lesions on images was judged two steps (on alone knowledge DWI) compared DWI. Results egative case positive DWI allocated to a time window 3 or less high specificity (0.93)...
Relapsing symptoms post herpes simplex virus-1 (HSV) encephalitis (HSVE) usually occur a few weeks after viral therapy and represent either 1) true relapse of HSVE (CSF PCR positive for HSV, new necrotic lesions on brain MRI, response to acyclovir therapy) or 2) disorder postulated be immune-mediated negative no lesions, acyclovir).1,2 It has been suggested that this may related NMDA receptor (NMDAR) antibodies,3 we recently reported child in whom relapsing were the presentation anti-NMDAR...
Background Treatment of individuals with asymptomatic carotid artery stenosis is still handled controversially. Recommendations for treatment endarterectomy (CEA) are based on trials having recruited patients more than 15 years ago. Registry data indicate that advances in best medical (BMT) may lead to a markedly decreasing risk stroke stenosis. The aim the SPACE-2 trial (ISRCTN78592017) was compare preventive effects BMT alone combination CEA or stenting (CAS), respectively, ≥70% European...
Intracerebral hemorrhage represents the most feared complication of treatment with intravenous tissue plasminogen activator. We studied whether perfusion-weighted imaging and diffusion-weighted has potential to identify patients at risk severe intracerebral after activator.We analyzed data prospectively MRI selected acute ischemic stroke treated activator within 6 hours. All were examined by perfusion- < or =6 Perfusion- lesion volumes calculated. Hemorrhagic transformation was assessed on...
Granulocyte colony-stimulating factor (G-CSF) is a promising stroke drug candidate. The present phase IIa study assessed safety and tolerability over broad dose range of G-CSF doses in acute ischemic patients explored outcome data.Four intravenous regimens (total cumulative 30-180 μg/kg the course 3 days) were tested 44 national, multicenter, randomized, placebo-controlled escalation (NCT00132470; www.clinicaltrial.gov). Main inclusion criteria 12-hour time window after onset, infarct...
To assess whether smoking cessation after an ischemic stroke or TIA improves outcomes compared to continued smoking. We conducted a prospective observational cohort study of 3,876 nondiabetic men and women enrolled in the Insulin Resistance Intervention After Stroke (IRIS) trial who were randomized pioglitazone placebo within 180 days qualifying followed up for median 4.8 years. A tobacco use history was obtained at baseline updated during annual interviews. The primary outcome, which not...
The perception of dyspnea and pain show many similarities. Initial imaging studies suggested an important role the insular cortex for both sensations. However, little is known about cortical processing dyspnea.This study investigated influence lesions on pain.Dyspnea was induced by resistive loaded breathing in four patients with right-hemispheric lesions, as assessed computer tomography or magnetic resonance imaging, matched healthy control subjects. Pain a cold-pressor test. Perceived...
Background and Purpose— Stroke magnetic resonance imaging with perfusion diffusion weighting has shown its potential to select patients likely benefit from intravenous thrombolysis tissue-type plasminogen activator (IV-tPA). We aimed determine the predictors of favorable outcome in imaging–selected, acute stroke treated IV-tPA. Methods— analyzed data ischemic a prospective, multicenter, observational study imaging–based IV-tPA treatment initiated ≤6 hours symptom onset. Neurologic deficit on...
Abstract Background Implementation of interventions to improve follow-up stroke care is complex due the involvement various stakeholders and challenges health coordination. The aim this study was evaluate process implementing a cross-sectoral, coordinated for patients (the StroCare intervention). Methods As part multicenter interventional trial, qualitative performed in pre-post design with semi-structured interviews conducted employees. multicomponent intervention implemented eight...
Alberta Stroke Program Early Computed Tomographic Score (ASPECTS) has been used to estimate diffusion-weighted imaging (DWI) lesion volume in acute stroke. We aimed assess correlations of DWI-ASPECTS with different middle cerebral artery (MCA) subregions and reproduce existing ASPECTS thresholds a malignant profile defined by ≥100 mL.We analyzed data patients MCA stroke from prospective observational study DWI fluid-attenuated inversion recovery were calculated. The population was divided...
<i>Background:</i> We applied magnetic resonance imaging to analyze the degree of local diffusion and perfusion abnormalities status reperfusion in regions with subsequent hemorrhagic transformation (HT). <i>Methods:</i> 51 patients acute ischemic stroke were studied by diffusion- perfusion-weighted within 3.0 ± 0.8 h, on day 1 days 5–8. After realignment image data sets, parameter maps apparent coefficient (ADC), cerebral blood flow (CBF) volume (CBV), mean transit...
We describe the regional distribution of acute perfusion, diffusion, and final infarct lesions in middle cerebral artery (MCA) trunk occlusion. A total 31 patients with ischemic stroke MCA occlusion were studied by multiparametric magnetic resonance imaging. Probabilistic maps lesion generated. The probability initial infarcts was highest central region decreasing toward periphery where tissue at risk infarction to be saved highest. brain regions being involved diffusion evolving into or...
<i>Background:</i> Carotid stenting carries a risk of periprocedural stroke. We aimed at determining predictors cerebral ischemic events associated with for symptomatic carotid stenosis. <i>Methods:</i> 127 patients who had been studied by diffusion-weighted MR imaging (DWI) before and on the day after were included. Six clinical variables 5 characterizing target artery aortic atherosclerosis analyzed as potential factors new ipsilateral DWI lesions stenting....
Background In patients with acute ischemic stroke, little is known regarding the frequency of abnormal ECG findings other than atrial fibrillation and their association cardiovascular outcomes. We aim to analyze type findings, subsequent changes in medical treatment, outcomes stroke. Methods Results investigator-initiated multicenter MonDAFIS (impact standardized monitoring for detection stroke) study, 3465 stroke or transient attack without were randomized 1:1 receive Holter-ECG up 7 days...
<i>Background:</i> Carotid artery stenting (CAS) is associated with the risk of intraprocedural stroke. A better understanding specific factors could help to improve procedure and reduce overall CAS. We addressed role carotid plaque echolucency as potential factor for cerebral embolism during <i>Methods:</i> prospectively evaluated by use a computer-assisted measure echogenicity, gray scale median (GSM), in 31 consecutive patients symptomatic high-grade stenosis that...
<i>Background:</i> Carotid-artery stenting (CAS) may be complicated by stroke. We aimed to determine predictors of procedure-related ischemic events. <i>Methods:</i> analyzed new lesions in diffusion-weighted MRI (DWI) after CAS 147 patients with symptomatic high-grade carotid stenosis. Nine covariates were assessed as potential risk factors for DWI: age, gender, hypertension, diabetes, dyslipidemia, smoking status, severity stenosis, side intervention and...
Transcranial high-resolution ultrasonography reliably allows diagnosis and monitoring of intracerebral hemorrhage in adults. Sonographic subdural hematoma (SDH) has not been evaluated adults so far. This study investigates the reliability transcranial gray-scale sonography (TGS) acute chronic SDH TGS was performed 47 consecutive patients with either or confirmed by cerebral CT. Four were excluded due to insufficient bone window. After identification extent measured correlated on computer...