A5091295266- Microwave and Dielectric Measurement Techniques
- Sepsis Diagnosis and Treatment
- Venous Thromboembolism Diagnosis and Management
- Microwave Engineering and Waveguides
- Aortic aneurysm repair treatments
- Vascular Procedures and Complications
- Blood Coagulation and Thrombosis Mechanisms
- Radio Frequency Integrated Circuit Design
- Immune Response and Inflammation
- Cerebrovascular and Carotid Artery Diseases
- Cardiac, Anesthesia and Surgical Outcomes
- Advanced Malware Detection Techniques
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Neuroendocrine Tumor Research Advances
- Near-Field Optical Microscopy
- Lung Cancer Research Studies
- Electromagnetic Compatibility and Measurements
- Abdominal vascular conditions and treatments
- Electromagnetic Compatibility and Noise Suppression
- Central Venous Catheters and Hemodialysis
- Dialysis and Renal Disease Management
- Acoustic Wave Resonator Technologies
- Photonic and Optical Devices
- Appendicitis Diagnosis and Management
- Integrated Circuits and Semiconductor Failure Analysis
Pius Hospital Oldenburg
2018-2025
University Hospital Heidelberg
2002-2025
Heidelberg University
2002-2025
University Medical Centre Mannheim
2021-2025
Swiss Federal Institute of Metrology
2015-2024
West German Heart and Vascular Center Essen
2015-2024
Liechtenstein Institute
2024
Ludwig-Maximilians-Universität München
2005-2023
Elisabeth-Krankenhaus Essen
2015-2023
Johannes Wesling Klinikum Minden
2019-2021
Smartphones in general and Android particular are increasingly shifting into the focus of cybercriminals. For understanding threat to security privacy it is important for researchers analyze malicious software written these systems. The exploding number malware calls automation analysis. In this paper, we present Mobile-Sandbox, a system designed automatically applications two novel ways: (1) combines static dynamic analysis, i.e., results analysis used guide extend coverage executed code,...
The reported survival data for glioblastoma patients vary strongly between different studies. In our study, we therefore examined which are applicable in a real-world population German center and how these perform comparison to presented randomized controlled trials (RCTs). Data of all treated with newly diagnosed single 2010 2019 were analyzed treatment patterns plus rates matched existing results RCTs. Two hundred thirty-three analyzed. Median age was 63 years, f/m ratio 1:162, 73%...
We are currently moving from the Internet society to a mobile where more and access information is done by previously dumb phones. For example, number of phones using full blown OS has risen nearly200% Q3/2009 Q3/2010. As result, security no longer immanent, but imperative. This survey paper provides concise overview network security, attack vectors back end system web browser, also hardware layer user as enabler. show differences similarities between "normal" draw conclusions for further...
To explore if patients with severe sepsis and a predicted high risk of death (according to the Simplified Acute Physiology Score II) might have treatment benefit from high-dose antithrombin III.Subgroup analysis randomized, placebo-controlled, double-blind, prospective phase III study.Unifactorial multifactorial reanalysis prospectively defined populations KyberSept trial.We studied 1,008 (43.6% overall intention-to-treat population, n = 2,314) mortality rate 30-60% at study entry as by...
The popularity of mobile devices like smartphones and tablets has increased significantly in the last few years with many millions sold devices. This growth also its drawbacks: attackers have realized that are an attractive target months different kinds malicious software (short: malware) for such emerged. worrisome development potential to hamper prospering ecosystem damage is huge.
Background Treatment of individuals with asymptomatic carotid artery stenosis is still handled controversially. Recommendations for treatment endarterectomy (CEA) are based on trials having recruited patients more than 15 years ago. Registry data indicate that advances in best medical (BMT) may lead to a markedly decreasing risk stroke stenosis. The aim the SPACE-2 trial (ISRCTN78592017) was compare preventive effects BMT alone combination CEA or stenting (CAS), respectively, ≥70% European...
Activation of thrombin and the coagulation system plays an important role in pathophysiology sepsis-associated organ dysfunction. Antithrombin III (AT III) is a natural inhibitor thrombin, central procoagulatory factor with pleiotropic activities. Experimental supplementation AT improved parameters ameliorated To determine whether long-term has beneficial effects on function, we conducted randomized, prospective study surgical patients severe sepsis. The evaluated effect (duration treatment:...
Objective To characterize microcirculatory actions of activated protein C in an endotoxemia rodent model that allows vivo studies microvascular inflammation and perfusion dysfunction. Design Animal study using intravital microscopy. Setting research facility. Subjects Male Syrian golden hamsters, 6–8 wks old with a body weight 60–80 g. Interventions In skinfold preparations, was induced by intravenous administration 2 mg/kg endotoxin (lipopolysaccharide, Escherichia coli). Intravital...
Background Increased leukocyte-endothelial cell interaction (LE) and deterioration of capillary perfusion represent key mechanisms septic organ dysfunction. The type volume support, however, which may be used during disorders, remains controversial. Using intravital microscopy, the authors studied effect different regimens clinically relevant support on endotoxin-induced microcirculatory including synthetic colloid hydroxyethyl starch (HES, 130 kD) a crystalloid regimen with isotonic saline...
Prothrombin complex concentrates are recommended for rapid reversal of vitamin K anticoagulants. As they normalize levels dependent clotting factors and re-establish hemostasis, may also be used as adjunctive therapy in patients with major bleeding. The aim this study was to retrospectively evaluate the efficacy prothrombin surgical setting. case notes 50 requiring urgent oral anticoagulation (n = 12) or severe perioperative coagulopathic bleeding 38) who received an infusion concentrate...
Antithrombin III (AT III) is an important inhibitor of thrombin activity, as well many other proteases the coagulation system. AT administration showed beneficial effects on septic multiple organ dysfunction in clinical and experimental studies. It was aim this study to determine whether continuous long-term supplementation alters systemic inflammatory response patients with severe sepsis. In a prospective study, 29 surgical sepsis were randomly assigned receive either conventional intensive...
Summary A randomised, prospective, placebo-controlled phase III multicentre clinical trial (KyberSept) has been performed to test the efficacy of high-dose antithrombin therapy in patients with severe sepsis. Concomitant low-dose heparin routinely given two thirds for deep vein thrombosis prophylaxis.This study analyses – interactions terms long-term mortality, adverse events, and thromboembolic events. From a total 2,314 sepsis (placebo: n=1,157; antithrombin: n=1,157) 1,616 811, 805)...
Plasmonic nano antennas are highly attractive at optical frequencies due to their strong resonances - even when size is smaller than the wavelength and because of potential extreme field enhancement. Such may be applied for sensing biological particles as well single molecule detection. Because considerable material losses dispersion metals frequencies, numerical analysis plasmonic very demanding. An additional difficulty caused narrow gaps between utilized increasing In this paper we...
Metas.UncLib is a software library that facilitates the linear propagation of uncertainties through measurement model. It able to handle complex-valued and multivariate quantities supports higher mathematics. therefore deal with advanced metrological problems require, e.g., matrix manipulations. The optimized for short computation times low memory use.
In malignant melanoma, liver metastases significantly reduce survival, even despite highly effective new therapies. Given the increase in metabolic diseases such as dysfunction-associated steatotic disease (MASLD) and steatohepatitis (MASH), this study investigated impact of sinusoidal endothelial cell (LSEC)-specific alterations MASLD/MASH on hepatic melanoma metastasis. Mice were fed a choline-deficient L-amino acid-defined (CDAA) diet for ten weeks to induce MASH-associated fibrosis, or...
Liposuction is a standard procedure in plastic surgery. Especially, lipectomy with suction of the lower extremities has been greater interest recent years. Until now, however, there was no definite information about integrity epifascial lymph collectors during this procedure. To study effect liposuction devices on vessel injury, postmortem lymphatic preparations were done five human cadavers (10 extremities). Conventional blunt 4-mm cannula and dry technique used. Adiposuction performed...
Lipectomy is a standard procedure in plastic surgery. Until now, however, there was no definite information about the influence of different liposuction techniques (tumescent versus dry liposuction) on integrity lymph collectors during this procedure. To study effect these incidence vessel injury, postmortem lymphatic preparations were done nine human cadavers (18 lower extremities). Conventional with blunt 4-mm cannula technique (n = 29 regions) compared tumescent 26). Liposuction performed...