A5052759316- Cerebrovascular and Carotid Artery Diseases
- Traumatic Brain Injury and Neurovascular Disturbances
- Acute Ischemic Stroke Management
- Economic and Social Issues
- German Literature and Culture Studies
- Intracranial Aneurysms: Treatment and Complications
- Cardiovascular Health and Disease Prevention
- Public Administration and Political Analysis
- German Social Sciences and History
- Vasculitis and related conditions
- Linguistic research and analysis
- Sociology and Education Studies
- Optical Imaging and Spectroscopy Techniques
- Critical Theory and Philosophy
- Psychoanalysis and Social Critique
- Heart Rate Variability and Autonomic Control
- Cardiovascular and Diving-Related Complications
- Advanced MRI Techniques and Applications
- Neurosurgical Procedures and Complications
- Religion, Theology, and Education
- Neurological Complications and Syndromes
- German legal, social, and political studies
- Aortic Thrombus and Embolism
- Diet and metabolism studies
- Cardiovascular Syncope and Autonomic Disorders
Jena University Hospital
2025
University of Hildesheim
2012-2024
Schwarzwald-Baar Klinikum
2018-2024
Universität Hamburg
2023
Martin Luther University Halle-Wittenberg
2023
Augustana-Hochschule Neuendettelsau
2012-2023
Jungheinrich (Germany)
2012-2023
Deutsche Nationalbibliothek
2012-2023
European University Viadrina
2012-2023
University of Konstanz
2023
Studies to date have shown an association between the presence of patent foramen ovale and cryptogenic stroke in patients younger than 55 years age. This has not been established age or older.We prospectively examined 503 consecutive who had a stroke, we compared 227 with 276 control known cause. We prevalences concomitant atrial septal aneurysm all patients, using transesophageal echocardiography. also data for 131 (< age) those 372 older (> = age).The prevalence was significantly greater...
Reinhard M, Rutsch S, Lambeck J, Wihler C, Czosnyka Weiller Hetzel A. Dynamic cerebral autoregulation associates with infarct size and outcome after ischemic stroke. Acta Neurol Scand: 2012: 125: 156–162. © 2011 John Wiley & Sons A/S. Objectives – Cerebral is particularly challenged in acute We investigated (1) clinical radiological factors related to dynamic (DCA) stroke (2) the relationship between DCA of Methods A total 45 patients middle artery (MCA) were analyzed pooling two previous...
Objective. To compare the impact of initial corticosteroid treatment on high-resolution MRI and colour-coded duplex sonography (CCDS) findings in patients with GCA (temporal). Methods. Sensitivity specificity CCDS contrast-enhanced studies 59 suspected were retrospectively analysed. Patients grouped according to duration steroid before imaging: 0–1 day, 2–4 days >4 days. In 41 patients, imaging results compared temporal artery biopsy (TAB). Results. Sixty-one per cent (36/59) diagnosed GCA....
Abstract Objective To compare the diagnostic performance of high‐resolution magnetic resonance imaging (MRI) and color‐coded duplex sonography (CCDS) in patients with giant cell (temporal) arteritis (GCA). Methods Results MRI CCDS 59 suspected GCA were compared final clinical diagnosis (based on American College Rheumatology criteria a 6‐month followup study). Sensitivity, specificity, positive negative predictive values (PPV, NPV) calculated for each method. In 41 patients, results also...
Both for hemicraniectomy and hypothermia, several reports describe a beneficial effect in patients with malignant supratentorial cerebral ischemia. We compared the safety clinical outcome infarction who were treated alone (HA) or received combination therapy hypothermia of 35 degrees C (HH), respectively.In prospective randomized study, 25 consecutive after an ischemic more than two thirds one hemisphere by HA (n=13 patients) HH (n=12 patients). Safety parameters between both treatment...
Background and Purpose— This study investigates dynamic cerebral autoregulation assessed from spontaneous blood pressure (ABP) flow velocity (CBFV) fluctuations its time course in acute ischemic stroke. Methods— Forty patients admitted with stroke the territory of middle artery (MCA) were enrolled. Admission National Institutes Health Stroke score was 6±4. Study 1 performed within 22 (±11) hours 2 134 (±25) ictus. The final analysis comprised 33 29 for 2, respectively. Twenty-five age-...
The aim of the present prospective study was to investigate whether hyperglycemia influences clinical outcome or infarct size after intravenous thrombolysis focal cerebral ischemia. A consecutive series hyperglycemic (n = 14) and normoglycemic patients 17) with acute ischemia (<3 h) in middle artery (MCA) territory received rtPA (0.9 mg/kg body weight) intravenously. Clinical measured using NIH Stroke Score on admission followed up until day 28. Infarct volume by diffusion-weighted MR...
Transesophageal echocardiography (TEE) is the gold standard in detecting high-risk (ie, aortic thrombi) and potential sources patent foramen ovale [PFO]) of cerebral embolism. We sought to evaluate additional information therapeutic impact provided by TEE stroke patients characterize whom indispensable.We included 503 consecutive (mean age 62.2 years) with acute brain ischemia. Each patient received following routine diagnostics: ultrasound supplying arteries, ECG or Holter-ECG,...
Abstract To determine three‐dimensional (3D) blood flow patterns in the carotid bifurcation, 10 healthy volunteers and nine patients with internal artery (ICA) stenosis ≥50% were examined by flow‐sensitive 4D MRI at 3T. Absolute mean velocities, pulsatility index (PI), resistance (RI) measured common arteries (CCAs) duplex sonography (DS) compared MRI. Furthermore, 3D bifurcation of before after recanalization graded two independent readers. Blood velocities 31–39% lower than DS. However, PI...
Background and Purpose— Estimation of dynamic cerebral autoregulation from spontaneous fluctuations arterial blood pressure (ABP) flow velocity (CBFV) is an attractive monitoring option for hemodynamic impairment. We evaluated the correlation coefficient index method in patients with severe obstructive carotid disease compared it transfer function analysis (frequency domain approach to autoregulation) CO 2 vasomotor reactivity. Methods— In 139 unilateral stenosis (≥70%) or occlusion, CBFV...
To assess whether smoking cessation after an ischemic stroke or TIA improves outcomes compared to continued smoking. We conducted a prospective observational cohort study of 3,876 nondiabetic men and women enrolled in the Insulin Resistance Intervention After Stroke (IRIS) trial who were randomized pioglitazone placebo within 180 days qualifying followed up for median 4.8 years. A tobacco use history was obtained at baseline updated during annual interviews. The primary outcome, which not...
Background Treatment of individuals with asymptomatic carotid artery stenosis is still handled controversially. Recommendations for treatment endarterectomy (CEA) are based on trials having recruited patients more than 15 years ago. Registry data indicate that advances in best medical (BMT) may lead to a markedly decreasing risk stroke stenosis. The aim the SPACE-2 trial (ISRCTN78592017) was compare preventive effects BMT alone combination CEA or stenting (CAS), respectively, ≥70% European...
Analysis of dynamic cerebral autoregulation (DCA) from spontaneous blood pressure fluctuations might contribute to prognosis severe internal carotid artery stenosis, but its response recanalization has not been investigated so far. This study investigates the effect endarterectomy or stenting on various DCA parameters.In 58 patients with unilateral stenosis undergoing (n=41) (n=17), flow velocity (CBFV, transcranial Doppler) and arterial (ABP, Finapres method) were recorded over 10 minutes...
Oscillations of arterial blood pressure (ABP) and cerebral flow velocity (CBFV) can be used for non-invasive assessment autoregulation using transfer function analysis. Either spontaneous oscillations (SPO) around 0.1 Hz or respiratory induced during deep breathing (DB) at a rate 6/min have been so far. We investigated 168 patients with severe carotid stenosis occlusion to evaluate analysis compare the SPO DB approaches. ABP was assessed non-invasively (Finapres), CBFV measured in middle...
<i>Background:</i> To investigate whether there is: (1) a specific temporal course of cerebral dysautoregulation in acute ischemic stroke, and (2) separate detrimental effect recombinant tissue plasminogen activator (rtPA) on autoregulation dynamics this situation. <i>Methods:</i> We studied 16 patients with middle artery (MCA) occlusion rtPA thrombolysis (intra-arterial or intravenous application, both). Controls were 71 healthy adults 11 minor stroke not receiving...
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