A5029614536- SARS-CoV-2 and COVID-19 Research
- Acute Ischemic Stroke Management
- Viral Infections and Vectors
- Cerebrovascular and Carotid Artery Diseases
- Cancer Immunotherapy and Biomarkers
- COVID-19 Clinical Research Studies
- SARS-CoV-2 detection and testing
- Colorectal Cancer Treatments and Studies
- Immunotherapy and Immune Responses
- Mosquito-borne diseases and control
- Viral Infections and Outbreaks Research
- Intracerebral and Subarachnoid Hemorrhage Research
- Intracranial Aneurysms: Treatment and Complications
- Animal Virus Infections Studies
- Muscle metabolism and nutrition
- Cerebrovascular and genetic disorders
- Respiratory viral infections research
- Biosensors and Analytical Detection
- Cardiovascular and Diving-Related Complications
- Parvovirus B19 Infection Studies
- Colorectal and Anal Carcinomas
- Lung Cancer Research Studies
- Toxoplasma gondii Research Studies
- Viral Infections and Immunology Research
- COVID-19 and healthcare impacts
Ospedale Santa Maria alle Scotte
2020-2023
University of Siena
2009-2022
Azienda Ospedaliera Universitaria Senese
2016-2022
Ospedale Sacro Cuore Don Calabria
2015-2022
Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani
2022
Istituti di Ricovero e Cura a Carattere Scientifico
2022
University of Genoa
1992-2021
University of Pavia
2018
University of Brescia
2018
University of Bari Aldo Moro
2016
Response to Vaccine after Recovery from Covid-19 The response the BNT162b2 vaccine was evaluated in 100 health care workers, 38 of whom had recovered Covid-19. Neutralizing antibody levels ...
A weak production of INF-β along with an exacerbated release pro-inflammatory cytokines have been reported during infection by the novel SARS-CoV-2 virus. encodes several proteins able to counteract host immune system, which is believed be one most important features contributing viral pathogenesis and development a severe clinical picture. Previous reports demonstrated that N protein, some non-structural accessory proteins, efficiently suppresses interacting RIG-I, pattern recognition...
To assess whether smoking cessation after an ischemic stroke or TIA improves outcomes compared to continued smoking. We conducted a prospective observational cohort study of 3,876 nondiabetic men and women enrolled in the Insulin Resistance Intervention After Stroke (IRIS) trial who were randomized pioglitazone placebo within 180 days qualifying followed up for median 4.8 years. A tobacco use history was obtained at baseline updated during annual interviews. The primary outcome, which not...
The mPEBev is an anticancer regimen which combines a chemotherapy doublet, based on cisplatin and oral etoposide (mPE), with bevacizumab (mPEBev), mAb targeting the vasculo-endothelial growth factor (VEGF). In previous studies, this showed powerful anti-angiogenetic effects significant antitumor activity in metastatic non-small-cell lung cancer (mNSCLC) patients. We also recorded best benefit patients exhibiting low-systemic inflammatory profile at baseline. On these bases, we hypothesized...
An increase in measles cases worldwide, with outbreaks, has been registered the last few years, despite availability of a safe and highly efficacious vaccine. In addition to an inadequate vaccination coverage, even high-income European countries studies proved that some vaccinated people were also found seronegative years after vaccination, thus increasing number susceptible infection. this study, we evaluated immunization status seroprevalence antibodies among 1092 healthy adults, either or...
Because there is uncertainty about the role of atherogenic and nonatherogenic risk factors for cerebral ischemia in young, we carried out a multicenter, hospital-based, case-control study. 333 patients (15–44 years) with focal (transient ischemic attack or stroke within 8 weeks admission) were eligible. 25 excluded, according to protocol. 308 cases matched by age gender one hospital population control. Independent was shown logistic conditional regression migraine aura [odds ratio (OR) =...
Real-time reverse transcription PCR is currently the most sensitive method to detect severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Defining whether a patient could be contagious or not in presence of residual SARS-CoV-2 RNA extreme importance context public health. In this prospective multicenter study, virus isolation was prospectively attempted 387 nasal swabs from clinically recovered patients showing low viral load (quantification cycle, Cq, value greater than 30). The...
We have designed a prospective study aiming to monitor the immune response in 178 health care workers six months after BNT162b2 mRNA vaccination.The humoral of all subjects was evaluated by chemiluminescence (CMIA); 60 serum samples, live virus-based neutralization assay also tested. Moreover, 6 vaccination, B- and T-cell subsets from 20 were observed FACS analysis restimulation with trimeric SARS-CoV-2 Spike protein as an antigen, thus mimicking reinfection vitro.A significant decrease...
<i>Background:</i> Epidemiological data are essential to estimate the burden of stroke.<i></i>We evaluated stroke incidence in older Italians and effect first-ever on survival activities daily living (ADL). <i>Methods:</i> The analysis was performed Italian Longitudinal Study Aging (ILSA) sample, consisting 5,632 individuals aged 65–84. ILSA aims at major cardiovascular neurological age-associated diseases. baseline survey 1992 detect prevalent...
<h3>Objective</h3> Although a concern exists that 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) might increase the risk of intracerebral haemorrhage (ICH), contribution these agents to relationship between serum cholesterol and disease occurrence has been poorly investigated. <h3>Methods</h3> We compared consecutive patients having ICH with age sex-matched stroke-free control subjects in case–control analysis, as part Multicenter Study on Cerebral Haemorrhage Italy...
We report detecting infectious Toscana virus in the seminal fluid of a 25-year-old man from Italy returning Elba Island. The presence human semen adds to long list viruses detected this genital and indicates potential for sexual transmission.
A weak production of INF-β along with an exacerbated release pro-inflammatory cytokines have been reported during infection by the novel SARS-CoV-2 virus. encodes several proteins that are able to counteract host immune system, which is believed be one most important features contributing viral pathogenesis and development a severe clinical outcomes. Previous reports demonstrated ORF6 protein strongly suppresses hindering RIG-I, MDA-5, MAVS signaling cascade. In present study, we better...
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is an inherited disease due to cerebral microangiopathy presenting variable pictures, including stroke, progressive cognitive impairment, disability. Mechanisms leading from vessel structural changes parenchymal damage eventually clinical expression are not fully understood. Among pathogenic processes, endothelial dysfunction has been hypothesized. Endothelial progenitor cells circulating...
ABSTRACT Respiratory syncytial virus (RSV) is a major cause of severe respiratory infections in children and elderly people, no marketed vaccine exists. In this study, we generated analyzed subunit against RSV based on novel genome replication-deficient Sendai (SeV) vector. We inserted the F protein, known to be genetically stable antigen, into our vector specific way optimize features. By exchanging ectodomain SeV protein for its counterpart from RSV, created chimeric vectored that contains...
Thymidylate synthase (TS) is a tumor-associated enzyme critical for DNA replication and main 5′-fluorouracil (5′-FU) target. TSPP/VAC1 multi-arm trial phase-Ib program aimed to investigate the toxicity biomodulatory activity of poly-epitope-peptide vaccine TS (TSPP) in cancer patients (pts). Here, we present results TSPP/VAC1/arm C evaluate TSPP combination with chemo-immunotherapy pretreated metastatic colo-rectal (mCRC) pts. Twenty-nine pts, 14 males 15 females, received poly-chemotherapy...
It is known that the non-structural protein (NSs) of Toscana virus (TOSV), an emergent sandfly-borne causing meningitis or more severe central nervous system injuries in humans, exerts its function triggering RIG-I for degradation a proteasome-dependent manner, thus breaking off IFN-β production. The different members Bunyavirales has recently appeared as fundamental protagonist immunity evasion through ubiquitination-mediated targets. We showed TOSV NSs E3 ubiquitin ligase activity, mapping...
<h3>Objective</h3> To investigate the role of alcohol as a causal factor for intracerebral hemorrhage (ICH) and whether its effects might vary according to pathogenic mechanisms underlying cerebral bleeding. <h3>Methods</h3> We performed case-control analysis, comparing cohort consecutive white patients with ICH aged 55 years older group age- sex-matched stroke-free controls, enrolled in setting Multicenter Study on Cerebral Haemorrhage Italy (MUCH-Italy) between 2002 2014. Participants were...
Due to their increased transmissibility, three variants of high concern have emerged in the United Kingdom (also known as B.1.1.7 lineage or VOC-202012/01), South Africa (B.1.351 lineage), and Brazil (P1 lineage) with multiple substitutions spike protein. Since neutralizing antibodies elicited by vaccination are likely considered correlates protection for SARS-CoV-2 infection, it is important analyze whether vaccinees mRNA BNT162b2 equally protected against these emerging variants. To this...
Radiotherapy (RT), together with a direct cytolytic effect on tumor tissue, also elicits systemic immunological events, which sometimes result in the regression of distant metastases (abscopal effect). We have shown safety and anti-tumor activity novel metronomic chemotherapy (mCH) regimen dose-fractioned cisplatin, oral etoposide bevacizumab, mAb against vasculo-endothelial-growth-factor (mPEBev regimen), metastatic non-small-cell-lung cancer (mNSCLC). This regimen, designed results...
Cerebral autosomal dominant angiopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is an hereditary disease whose clinical expression a stepwise vascular dementia. Initial presentation of the involves transient or stabilized focal neurological deficits, migraine mood changes. Recently, high prevalence right-to-left shunt (RLS) due to patent foramen ovale has been reported in subjects migraine. The aim our study was determine RLS CADASIL without migraine.We performed...