Rossana Tassi
A5086298713- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Venous Thromboembolism Diagnosis and Management
- Atrial Fibrillation Management and Outcomes
- Stroke Rehabilitation and Recovery
- Intracerebral and Subarachnoid Hemorrhage Research
- Intracranial Aneurysms: Treatment and Complications
- Traumatic Brain Injury and Neurovascular Disturbances
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiovascular Health and Disease Prevention
- Cardiac Arrhythmias and Treatments
- Neurological Complications and Syndromes
- Cerebral Venous Sinus Thrombosis
- Long-Term Effects of COVID-19
- Neurosurgical Procedures and Complications
- Protease and Inhibitor Mechanisms
- Cardiac tumors and thrombi
- Cardiac Imaging and Diagnostics
- Aortic Disease and Treatment Approaches
- Cerebrovascular and genetic disorders
- Neurological Disorders and Treatments
- Moyamoya disease diagnosis and treatment
- Peripheral Artery Disease Management
- COVID-19 and healthcare impacts
- Vascular Malformations Diagnosis and Treatment
Azienda Ospedaliera Universitaria Senese
2016-2025
Ospedale Santa Maria alle Scotte
2013-2024
University of Siena
2001-2024
Policlinico Umberto I
2024
Sapienza University of Rome
2002-2024
University of Florence
2013-2024
Population Health Research Institute
2024
McMaster University
2024
John Wiley & Sons (United States)
2023
Hudson Institute
2023
Background and Purpose— The best time for administering anticoagulation therapy in acute cardioembolic stroke remains unclear. This prospective cohort study of patients with atrial fibrillation, evaluated (1) the risk recurrent ischemic event severe bleeding; (2) factors recurrence (3) risks bleeding associated anticoagulant its starting after stroke. Methods— primary outcome this multicenter was composite stroke, transient attack, symptomatic systemic embolism, cerebral major extracranial...
Background The optimal timing to administer non–vitamin K oral anticoagulants ( NOAC s) in patients with acute ischemic stroke and atrial fibrillation is unclear. This prospective observational multicenter study evaluated the rates of early recurrence major bleeding (within 90 days) their who received s for secondary prevention. Methods Results Recurrence was defined as composite stroke, transient attack, symptomatic systemic embolism, cerebral extracranial bleeding. For analysis, 1127 were...
Background and Purpose- Despite treatment with oral anticoagulants, patients nonvalvular atrial fibrillation (AF) may experience ischemic cerebrovascular events. The aims of this case-control study in AF were to identify the pathogenesis risk factors for events occurring during non-vitamin K antagonist anticoagulants (NOACs) therapy stroke prevention. Methods- Cases consecutive who had acute NOAC treatment. Controls did not have NOACs Results- Overall, 713 cases (641 strokes 72 transient...
Background and Purpose— The beneficial effect of intravenous thrombolytic therapy in patients with acute ischemic stroke attributable to internal carotid artery (ICA) occlusion remains unclear. aim this study was evaluate the efficacy safety recombinant tissue-type plasminogen activator these patients. Methods— ICARO a case-control multicenter on prospectively collected data. Patients ICA treated within 4.5 hours from symptom onset (cases) were compared matched not (controls). Cases controls...
Background and Purpose— Experimentally, matrix metalloproteinases (MMPs) play a detrimental role related to hemorrhagic transformation severity of an ischemic brain lesion. Tissue-type plasminogen activator (tPA) enhances such effects. This study aimed expand clinical evidence in this connection. Methods— We measured MMPs 1, 2, 3, 7, 8, 9, tissue inhibitors 4 circulating level blood taken before 24 hours after tPA from 327 patients (mean age, 68.9±12.1 years; median National Institutes...
Background In patients with acute ischemic stroke and atrial fibrillation, early anticoagulation prevents recurrence but the risk of hemorrhagic transformation ( HT ). The aims this study were to evaluate in consecutive fibrillation (1) incidence HT, (2) time initiation , (3) association recurrences, (4) clinical outcome at 90 days. Methods Results was diagnosed by a second brain computed tomographic scan performed 24 72 hours after onset. recurrences as well mortality or disability...
Background and Purpose: As numerous questions remain about the best anesthetic strategy during thrombectomy, we assessed functional radiological outcomes in stroke patients treated with thrombectomy presence of general anesthesia (GA) versus conscious sedation (CS) local (LA). Methods: We conducted a cohort study on prospectively collected data from 4429 enrolled Italian Registry Endovascular Treatment Acute Stroke. Results: GA was used 2013 patients, CS 1285 LA 1131 patients. The rates...
Background and Purpose— As a reliable scoring system to detect the risk of symptomatic intracerebral hemorrhage after thrombectomy for ischemic stroke is not yet available, we developed nomogram predicting in patients with large vessel occlusion anterior circulation who received bridging intravenous thrombolysis (training set), validate model by using cohort treated direct (test set). Methods— We conducted study on prospectively collected data from 3714 enrolled IER (Italian Registry...
Randomized controlled trials (RCTs) proved that short-term (21-90 days) dual antiplatelet therapy (DAPT) reduces the risk of early ischemic recurrences after a noncardioembolic minor stroke or high-risk transient attack (TIA) without substantially increasing hemorrhagic risk. We aimed at understanding whether and how real-world use DAPT differs from RCTs.READAPT (Real-Life Study on Short-Term Dual Antiplatelet Treatment in Patients With Ischemic Stroke TIA) is prospective cohort study...
Background and Purpose: To evaluate outcome safety of endovascular treatment beyond 6 hours onset ischemic stroke due to large vessel occlusion in the anterior circulation, routine clinical practice. Methods: From Italian Registry Endovascular Thrombectomy, we extracted data patients treated for known hours. Additional inclusion criteria were prestroke modified Rankin Scale score ≤2 ASPECTS ≥6. Patients selected on individual basis by a combination CT perfusion mismatch (difference between...
There are limited data concerning procedure-related complications of endovascular thrombectomy for large vessel occlusion strokes.We evaluated the cumulative incidence, clinical relevance in terms increased disability and mortality, risk factors complications.From January 2011 to December 2017, 4799 patients were enrolled by 36 centers Italian Registry Endovascular Stroke Treatment. Data on demographic procedural characteristics, complications, outcome at three months prospectively...
Abstract Purpose Acute ischemic stroke (AIS) due to tandem lesions (TLs) of extracranial Internal Carotid Artery and Anterior Cerebral Circulation are challenging for endovascular treatment (EVT). This study aims evaluate feasibility, safety efficacy EVT TLs’ AIS, with or without emergent carotid artery stenting (eCAS), in a real-life scenario. Methods Retrospective review prospectively collected non-randomized thrombectomy databases from five centers between 2015 2019. Consecutive patients...
: The spatial and temporal distribution of intracerebral hemorrhage (ICH) recurrence are largely unknown. To assess timing location recurrent ICH events in relation to the index event (adjacent [adjICH] vs remote [remICH]). This cohort study was a pooled analysis individual studies from 2002 2021 among hospital-based European cohorts. Patients with 2 or more clinically distinguishable (≥1 recurrent) small vessel disease-related were included. Data performed December 2023 2024. underlying...
The benefits and safety of mechanical thrombectomy (MT) in patients with prestroke disability, classified as modified Rankin Scale (mRS) score 3 to 4, anterior circulation stroke remain uncertain. This study aims evaluate these factors using data from the Italian Registry Endovascular Treatment Acute Stroke. We analyzed collected between 2015 2021, comparing functional outcomes (mRS), symptomatic intracerebral hemorrhage, recanalization rates (Thrombolysis Cerebral Infarction) at 90 days...
The modified Rankin Scale (mRS) and the Barthel Index (BI) are most common clinimetrical instruments for measuring disability after stroke. This study investigated relationship between BI mRS at multiple time points BI, which is a widely used instrument longitudinal follow-up post-stroke, was as reference to determine effect of on sensitivity in differentiating functional recovery.Ninety-two patients with first stroke hemispheric brain lesion were evaluated using 10 days, 3 6 months....
Inflammatory mediators and metalloproteinases are altered in acute ischemic stroke (AIS) play a detrimental effect on clinical severity hemorrhagic transformation of the brain lesion. Using data from Italian multicenter observational MAGIC (MArker bioloGici nell'Ictus Cerebrale) Study, we evaluated inflammatory profiles three-month functional outcome, mortality 327 patients with AIS treated intravenous thrombolys according to SITS-MOST (Safe Implementation Thrombolysis Stroke-MOnitoring...
Although pathogenesis of small vessel disease is poorly understood, increasing evidence suggests that endothelial dysfunction may have a relevant role in development and progression disease. In this cross-sectional study, we investigated the associations between imaging signs blood biomarkers at two different time points population ischaemic stroke patients.In patients treated with intravenous thrombolysis, analysed levels von Willebrand factor, intercellular adhesion molecule-1, vascular...
Acute ischemic stroke and large vessel occlusion can be concurrent with the coronavirus disease 2019 (COVID-19) infection. Outcomes after mechanical thrombectomy (MT) for in patients COVID-19 are substantially unknown. Our aim was to study early outcomes MT COVID-19.Multicenter, European, cohort involving 34 centers France, Italy, Spain, Belgium. Data were collected between March 1, 2020 May 5, 2020. Consecutive laboratory-confirmed cases occlusion, who treated MT, included. Primary...