A5089742278- Pituitary Gland Disorders and Treatments
- Hormonal Regulation and Hypertension
- Adrenal Hormones and Disorders
- Multiple Sclerosis Research Studies
- Adrenal and Paraganglionic Tumors
- Growth Hormone and Insulin-like Growth Factors
- Advanced Neuroimaging Techniques and Applications
- Neuroendocrine Tumor Research Advances
- Sexual Differentiation and Disorders
- Stress Responses and Cortisol
- Glioma Diagnosis and Treatment
- Functional Brain Connectivity Studies
- Peripheral Neuropathies and Disorders
- Advanced MRI Techniques and Applications
- Thyroid Cancer Diagnosis and Treatment
- Ultrasound and Hyperthermia Applications
- Lung Cancer Research Studies
- Vestibular and auditory disorders
- Testicular diseases and treatments
- Circadian rhythm and melatonin
- Cardiovascular Disease and Adiposity
- Adipose Tissue and Metabolism
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- HIV-related health complications and treatments
- Adipokines, Inflammation, and Metabolic Diseases
Sapienza University of Rome
2016-2025
Policlinico Umberto I
2015-2024
Oxford Centre for Diabetes, Endocrinology and Metabolism
2016-2022
Oxford University Hospitals NHS Trust
2022
Azienda di Rilievo Nazionale ed Alta Specializzazione
2022
University of Oxford
2013-2020
Churchill Hospital
2016-2020
OLVG
2018
University College London
2018
Istituto Neurologico Mediterraneo
2017
Diffusion tensor imaging (DTI) is an effective means of quantifying parameters demyelination and axonal loss. The application DTI in Multiple Sclerosis (MS) has yielded noteworthy results. abnormalities, which are already detectable patients with clinically isolated syndrome (CIS), become more pronounced as disease duration neurological impairment increase. assessment the microstructural alterations white grey matter MS may shed light on mechanisms responsible for irreversible disability...
Neurodegeneration is the main cause for permanent disability in multiple sclerosis. The effect of current immunomodulatory treatments on neurodegeneration insufficient. Therefore, direct neuroprotection and myeloprotection remain an important therapeutic goal. Targeting acid-sensing ion channel 1 (encoded by ASIC1 gene), which contributes to excessive intracellular accumulation injurious Na+ Ca2+ over-expressed acute sclerosis lesions, appears be a viable strategy limit cellular injury that...
To investigate, by using resting-state (RS) functional magnetic resonance (MR) imaging, thalamocortical connectivity (FC) and its correlations with cognitive impairment in multiple sclerosis (MS).All subjects provided written informed consent; the study protocol was approved university institutional review board for this HIPAA-compliant study. Forty-eight patients relapsing-remitting MS 24 control underwent multimodal MR including diffusion-tensor three-dimensional (3D) T1-weighted imaging...
Multiple sclerosis (MS) is characterized by demyelinating and degenerative processes within the central nervous system. Unlike conventional MRI,new advanced imaging techniques improve pathological specificity better highlight relationship between anatomical damage clinical impairment.To investigate disability both grey (GM) white matter (WM) regional in MS patients.Thirty-six relapsing remitting-MS patients 25 sex- age-matched controls were enrolled. All clinically evaluated Expanded...
Purpose To determine if high-intensity, task-oriented, visual feedback training with a video game balance board (Nintendo Wii) induces significant changes in diffusion-tensor imaging ( DTI ) parameters of cerebellar connections and other supratentorial associative bundles these are related to clinical improvement patients multiple sclerosis. Materials Methods The protocol was approved by local ethical committee; each participant provided written informed consent. In this 24-week, randomized,...
Purpose To combine two unbiased (ie, without any a priori hypothesis) magnetic resonance (MR) imaging processing approaches, tract-based spatial statistics and voxel-based morphometry, to investigate the relationship between white matter gray damage computer-based measures of balance impairment assessed at static posturography in patients with multiple sclerosis (MS). Materials Methods Institutional review board approval written informed consent were obtained. Forty-five ambulatory MS (34...
Adrenal insufficiency (AI) requires lifelong glucocorticoid (GC) replacement. Conventional therapies do not mimic the endogenous cortisol circadian rhythm. Clock genes are essential components of machinery controlling functions and influenced by GCs. However, clock gene expression has never been investigated in patients with AI.To evaluate effect timing GC administration on peripheral blood mononuclear cells (PBMCs) from Dual Release Hydrocortisone vs Glucocorticoid Replacement...
The short ACTH stimulation test (250 μg) is the dynamic most frequently used to assess adrenal function. It possible that a single basal cortisol could be predict response, but research has been hampered by use of different assays and thresholds.To propose morning baseline criterion three commonly modern immunoassays - Advia Centaur (Siemens), Architect (Abbott) Roche Modular System (Roche) sufficiency.Observational, retrospective cross-sectional study at two centres.Retrospective analysis...
When should 'not so rare' Leydig cell tumors (LCTs) of the testis be suspected, diagnosed, and treated?LCTs are more frequent than generally believed, associated with male infertility, cryptorchidism gynecomastia, treated conservatively (in compliant patients) active surveillance, which appears to a safe alternative surgical enucleation.Increasing referrals for testicular imaging have led an increase in findings LCTs. The features natural history these remain largely unknown, as available...
The 250-μg short Synacthen (corticotropin) test (SST) is the most commonly used tool to assess hypothalamo-pituitary-adrenal (HPA) axis function. There are many potentially reversible causes of adrenal insufficiency (AI), but no data guide clinicians as frequency repeat testing or likelihood HPA recovery. To use SST results predict A retrospective analysis 1912 SSTs data. Seven hundred seventy-six patients with AI were identified who had at least two performed. subgroup was performed on...
Background Low-grade incomplete post-dexamethasone cortisol suppression in patients with adrenal incidentalomas – recently defined as possible autonomous secretion (pACS) has been associated increased cardiovascular events and mortality. However, prospective studies documenting cardiac abnormalities these are lacking. Subjects methods Between July 2016 September 2017, 71 consecutive lesions were prospectively screened for hypercortisolism by dexamethasone test (NCT 02611258). Complete...
Vaccine-induced thrombotic thrombocytopenia with cerebral venous thrombosis is a syndrome recently described in young adults within two weeks from the first dose of ChAdOx1 nCoV-19 vaccine. Here we report cases malignant middle artery (MCA) infarct and 9-10 days following vaccination. The arrived our facility around same time but different geographical areas, potentially excluding epidemiological links; meanwhile, no abnormality was found respective vaccine batches. Patient 1 57-year-old...
Radiotherapy is a valuable treatment in the management algorithm of pituitary adenomas and craniopharyngiomas. However, risk second brain tumour following radiotherapy major concern. We assessed this using non-irradiated patients with same primary pathology imaging surveillance as controls.In multicentre, retrospective cohort study, 4292 adenoma or craniopharyngioma were identified from departmental registries at six adult endocrine centres (Birmingham, Oxford, Leeds, Leicester, Bristol, UK...
To assess, by means of magnetic resonance (MR) imaging, the longitudinal changes in white matter (WM) and gray (GM) a cohort patients with clinically isolated syndrome (CIS) who were followed up for 1 year.This prospective, HIPAA-compliant study was approved institutional review board. Written informed consent obtained from all participants. Changes GM WM integrity respectively investigated using three-dimensional T1-weighted diffusion-tensor (DT) imaging sequences applying voxel-based...
To quantify white matter (WM) and gray (GM) damage in patients who presented with clinically isolated syndrome (CIS), which is suggestive of multiple sclerosis (MS), by combining volume-based morphometry (VBM) tract-based spatial statistics (TBSS).This prospective HIPAA-compliant study was approved the institutional review board. Written informed consent obtained from all participants. In this study, 34 consecutive (21 women, 13 men; mean age, 31.7 years +/- 7.7 [standard deviation]) CIS...