A5057061459- Hormonal Regulation and Hypertension
- Adipose Tissue and Metabolism
- Cardiovascular Disease and Adiposity
- Stress Responses and Cortisol
- Adrenal Hormones and Disorders
- Cardiovascular Effects of Exercise
- Diabetes Treatment and Management
- Muscle Physiology and Disorders
- Biochemical effects in animals
- Cardiac electrophysiology and arrhythmias
- Angiogenesis and VEGF in Cancer
- Chronic Kidney Disease and Diabetes
- Circadian rhythm and melatonin
- Adipokines, Inflammation, and Metabolic Diseases
- Tissue Engineering and Regenerative Medicine
- Obstructive Sleep Apnea Research
- Cardiac Structural Anomalies and Repair
- Receptor Mechanisms and Signaling
- Sirtuins and Resveratrol in Medicine
- Apelin-related biomedical research
- Nutrition and Health in Aging
- Radiative Heat Transfer Studies
- Nuclear Engineering Thermal-Hydraulics
- Sexual Differentiation and Disorders
- Autoimmune and Inflammatory Disorders Research
Sapienza University of Rome
1979-2020
Policlinico Umberto I
2016
University of British Columbia
2016
University of Campania "Luigi Vanvitelli"
2010
University of Naples Federico II
2010
Marconi University
1980
Acute skeletal muscle injury triggers an expansion of fibro/adipogenic progenitors (FAPs) and a transient stage fibrogenesis characterized by extracellular matrix deposition. While the perpetuation such phase can lead to permanent tissue scarring, consequences its suppression remain be studied. Using model acute damage we were able determine that pharmacological inhibition FAP Nilotinib, tyrosine kinase inhibitor with potent antifibrotic activity, exerts detrimental effect on myogenesis...
Adrenal insufficiency (AI) requires lifelong glucocorticoid (GC) replacement. Conventional therapies do not mimic the endogenous cortisol circadian rhythm. Clock genes are essential components of machinery controlling functions and influenced by GCs. However, clock gene expression has never been investigated in patients with AI.To evaluate effect timing GC administration on peripheral blood mononuclear cells (PBMCs) from Dual Release Hydrocortisone vs Glucocorticoid Replacement...
Visceral adiposity plays a significant role in cardiovascular risk. PDE5 inhibitors (PDE5i) can improve cardiac function and insulin sensitivity type 2 diabetes patients.To investigate whether PDE5i affect visceral adipose tissue (VAT), specifically epicardial fat (epicardial [EAT]), what mechanism is involved, using microarray-based profiling of pharmacologically modulated microRNA (miRNAs).Randomized, double-blind, placebo-controlled study diabetes.A total 59 diabetic patients were...
LH gene mutations are rare; only four have been described. The affected individuals hypogonadal.We describe the clinical features of a 31-yr-old man who presented with delayed puberty and azoospermia was found to hypogonadism associated an absence circulating LH.The patient had 12-bp deletion in exon 2 β-subunit mutation 5' splice site IVS2+1G→T same present compound heterozygous state. first predicts leucines hydrophobic core signal peptide. second disrupts splicing mRNA, generating gross...
Obesity and its co-morbidities may adversely affect bone mineral density (BMD). Obstructive sleep apnea (OSA) is a major complication of obesity. To date, the effects OSA on BMD in obese patients have been poorly studied.To examine whether severity independently correlates with patients.One hundred fifteen subjects (Apnea/Hypopnea Index [AHI] ≥5 events per hour) were included study. was measured at lumbar spine, total hip, femoral neck by dual energy X-ray absorptiometry. Body mass index,...
Abstract Diabetic Nephropathy (DN) is the leading cause of end-stage renal disease. Preclinical and experimental studies show that PDE5 inhibitors (PDE5is) exert protective effects in DN improving perivascular inflammation. Using a mouse model diabetic kidney injury we investigated proprieties PDE5is on hemodynamics molecular mechanisms involved. PDE5i treatment prevented development DN-related hypertension ( P < 0.001), increase urine albumin creatinine ratio 0.01), fall glomerular...
Vascular dysfunction is a common feature in end-organ complications of type 2 diabetes mellitus (T2DM). The endothelium-specific receptor tyrosine kinase Tie2 and its ligand, angiopoietin-1 (Ang1), participate the processes vessel repair, renewal, maturation. However, their dysregulation T2DM has seldom been investigated.To examine relationship between angiogenic Tie2-expressing monocytes (TEMs) Ang1, pharmacological modulation by phosphodiesterase 5 inhibitor (PDE5i) sildenafil, db/db mouse...
Different adipose tissue (AT) depots are associated with multiple metabolic risks. Phosphodiesterase type 5 (PDE5) is involved in adipocyte physiology and PDE5 inhibition may affect adipogenesis ameliorate white AT quality. The aim of this study to investigate the distribution composition stroma-vascular fraction (SVF) subcutaneous (SAT) 2 diabetic mice after prolonged treatment a inhibitor, Sildenafil. 18 db/db were treated Sildenafil or vehicle for 12 weeks. was monitored SAT processed...
Aim of the study was to evaluate USPIO labeling in different macrophage populations using a clinical 3.0T MR unit with optical and electron microscopy as gold standard. Human monocytic cell line THP‐1 cells were differentiated into macrophages. Afterwards, M0 macrophages incubated IL‐4 IL‐13 order obtain M2 polarized or IFN‐gamma LPS for classical activation (M1). These groups USPIO‐MR contrast agent (P904) 36 hr; M0, + P904, M1 P904 analyzed gel phantoms scanner. m‐RNA markers confirmed...
Adrenal insufficiency (AI), caused by adrenal failure (primary) or hypothalamo-pituitary (secondary), has a prevalence of 250–450 per 1 million (16). AI is potentially life-threatening and requires lifelong glucocorticoid replacement therapy. Modified-release hydrocortisone preparations have been developed to mimic the physiological cortisol rhythm improve compliance (17, 18). The once-daily, modified-release tablet was prevent afternoon peaks seen with conventional therapies given in...
Background Clinical studies suggest that testosterone (T) plays an important role in the male predominance of clinical manifestations Brugada syndrome (BS). However, no statistically significant correlations have been observed between T levels and electrocardiogram (ECG) parameters BS patients. We investigated whether hormonal pattern variation within CAG repeat polymorphism exon 1 androgen receptor (AR) gene, affecting sensitivity, are associated with ECG phenotype males. Methods Results 16...
Abstract The cardiac stroma contains multipotent mesenchymal progenitors. However, lineage relationships within stromal cells are still poorly understood. Here, we identify heart-resident PDGFRa + Sca-1 as Fibro/Adipogenic Progenitors (cFAPs) and show that they respond to ischemic damage by generating fibrogenic cells. Pharmacological blockade of this differentiation step with an anti-fibrotic tyrosine kinase inhibitor decreases post-myocardial infarction (MI) remodeling leads improvements...