A5017636811- Pituitary Gland Disorders and Treatments
- Adrenal and Paraganglionic Tumors
- Electrolyte and hormonal disorders
- Ovarian function and disorders
- Ophthalmology and Eye Disorders
- Migraine and Headache Studies
- Growth Hormone and Insulin-like Growth Factors
- Thyroid Disorders and Treatments
- Thyroid Cancer Diagnosis and Treatment
- Adrenal Hormones and Disorders
- Multiple Sclerosis Research Studies
- Neuroendocrine Tumor Research Advances
- Peripheral Neuropathies and Disorders
- Hormonal Regulation and Hypertension
- Cancer, Hypoxia, and Metabolism
- Neuroblastoma Research and Treatments
- Mitochondrial Function and Pathology
- Gestational Diabetes Research and Management
- Cancer Genomics and Diagnostics
- Glioma Diagnosis and Treatment
- Primary Care and Health Outcomes
- Congenital limb and hand anomalies
- Sexual Differentiation and Disorders
- Cardiovascular Issues in Pregnancy
- Lung Cancer Research Studies
University Hospitals of Leicester NHS Trust
2015-2025
Leicester Royal Infirmary
2012-2024
University of Leicester
2013-2024
Society for Endocrinology
2016-2022
Leeds Teaching Hospitals NHS Trust
2018
Lafayette College
2017
Leicester General Hospital
2013
Diabetes Australia
2013
Endocrine Society
2013
National Institute for Health Research
2013
The clinical characteristics of 84 patients with pituitary tumour who had troublesome headache were investigated. presented chronic (46%) and episodic (30%) migraine, short-lasting unilateral neuralgiform attacks conjunctival injection tearing (SUNCT; 5%), cluster (4%), hemicrania continua (1%) primary stabbing (27%). It was not possible to classify the according International Headache Society diagnostic criteria in six cases (7%). Cavernous sinus invasion present minority presentations...
The novel neuropeptides orexin A and B are selectively synthesised in the lateral posterior hypothalamus involved hypothalamic regulation of autonomic neuroendocrine functions. Recent findings point also to a role nociception. As is central modulation nociception we studied effects hypocretin/orexin receptor activation area (PH) rat on dural nociceptive input. Orexins were microinjected into PH responses neurones caudal trigeminal nucleus studied. Injection decreased A- C-fibre electrical...
Summary Objective Women with polycystic ovary syndrome ( PCOS ) are potentially at increased risk of cardiovascular CV diseases due to well‐established factors, including insulin resistance, obesity and type 2 diabetes mellitus T DM ). However, data showing excess events in this population still lacking. We investigated the incidence prevalence a cohort women . Design Retrospective study (total follow‐up >12 000 person‐years). Setting L eicester, eicestershire R utland (Total Female 434...
Gigantism results when a growth hormone-secreting pituitary adenoma is present before epiphyseal fusion. In 1909, Harvey Cushing examined the skeleton of an Irish patient who lived from 1761 to 1783, he noted enlarged fossa. We extracted DNA patient's teeth and identified germline mutation in aryl hydrocarbon-interacting protein gene (AIP). Four contemporary Northern families presented with gigantism, acromegaly, or prolactinoma have same haplotype associated mutated gene. Using coalescent...
Background: Pituitary tumors are commonly associated with disabling headache.The accepted mechanisms for headache dural stretch and cavernous sinus invasion.Objective: To determine if there is a relationship between pituitary tumor size the report of headache.Design: We prospectively studied 63 patients who were initially seen tumors.Clinical scores, volume, extent invasion obtained each patient.Results: The prevalence was 70%.There no positive correlation clinical head-ache score volume...
Abstract Current practical evidence‐based acute treatments of cluster headache are limited to subcutaneous and intranasal formulations sumatriptan, oxygen. Two small randomized, double‐blind trials suggested efficacy somatostatin in headache. We sought determine whether octreotide, a analog, is effective the abortive treatment Patients with episodic chronic headache, as defined by International Headache Society, were recruited placebo‐controlled crossover study. instructed treat two attacks...
Radiotherapy is a valuable treatment in the management algorithm of pituitary adenomas and craniopharyngiomas. However, risk second brain tumour following radiotherapy major concern. We assessed this using non-irradiated patients with same primary pathology imaging surveillance as controls.In multicentre, retrospective cohort study, 4292 adenoma or craniopharyngioma were identified from departmental registries at six adult endocrine centres (Birmingham, Oxford, Leeds, Leicester, Bristol, UK...
Recent data show that patients with a diagnosis of diabetes insipidus (DI) are coming to harm. Here we give the rationale for name change arginine vasopressin deficiency and resistance central nephrogenic DI, respectively.
Headache is a common problem in patients with pituitary tumours. Small lesions can cause debilitating headache, suggesting that the size of tumour may not be only causal factor pituitary-related headache. We present two cases prolactinoma-associated The first case has clinical diagnosis short-lasting unilateral headache attacks conjunctival injection and tearing (SUNCT). second hemicrania continua idiopathic stabbing In each case, administration dopamine agonists led to an exacerbation...
Objective Achieving optimal thyroid hormone replacement is more difficult in TSH deficiency compared to primary hypothyroidism because of the inability be guided by serum levels. A combination clinical symptoms and free thyroxine levels (fT4) are typically used make a diagnosis monitor replacement. We investigated patients with pituitary disease adequacy levothyroxine disease. Design Using our department's information system, we identified all any type tumour who had been seen clinic over...
Objective To determine if functional imaging using 11 C-methionine positron emission tomography co-registered with 3D gradient echo MRI (Met-PET/MRI), can identify sites of residual active tumour in treated acromegaly, and discriminate these from post-treatment change, to allow further targeted treatment. Design/methods Twenty-six patients persistent acromegaly after previous treatment, whom appearances were considered indeterminate, referred our centre for evaluation over a 4.5-year period....
Cranial diabetes insipidus (CDI) is a treatable chronic condition that can potentially develop into life-threatening medical emergency. CDI due to the relative or absolute lack of posterior pituitary hormone vasopressin (AVP), also known as anti-diuretic hormone. AVP deficiency results in uncontrolled diuresis. Complete lead polyuria exceeding 10 L/24 h. Given functioning thirst mechanism and free access water, patients with normally maintain adequate fluid balance through increased...
Abstract Objective The optimal approach to the surveillance of non-functioning pituitary microadenomas (micro-NFPAs) is not clearly established. Our aim was generate evidence on natural history micro-NFPAs support patient care. Design Multi-centre, retrospective, cohort study involving 23 endocrine departments (UK NFPA consortium). Methods Clinical, imaging, and hormonal data micro-NFPA cases between January, 1, 2008 December, 21, 2021 were analysed. Results Data for 459 patients retrieved...
ABSTRACT Objective To determine characteristics and pregnancy outcomes in women with primary adrenal insufficiency (PAI). Design Retrospective multicentre cohort study. Setting Twenty‐three maternity units the UK Ireland. Sample Seventy‐nine PAI who had 101 pregnancies. Method chart analysis. Main Outcome Measures Adrenal crisis, outcomes. Results We obtained data on pregnancies 79 PAI. Most (51, 64.1%) autoimmune disease, 8 (10.3%) prior infarction/surgery/haemorrhage, 2 (2.6%) congenital...
Autoimmune hypophysitis is a rare chronic inflammatory condition of the pituitary gland which typically presents with hypopituitarism and mass. Cases involving anterior alone (65%) are six times more common in women, presenting during pregnancy or postpartum (57%). Anterior posterior involvement (25%) twice as neurohypophysis (10%) occurs equally both sexes. It has prevalence around 5 per million, an annual incidence 1 7 to 9 million our experience represents known suspected cause 0.5% cases...