A5081278059- Medical Imaging Techniques and Applications
- Radiopharmaceutical Chemistry and Applications
- Radiomics and Machine Learning in Medical Imaging
- Advanced X-ray and CT Imaging
- Advanced MRI Techniques and Applications
- Lymphoma Diagnosis and Treatment
- Advanced Radiotherapy Techniques
- Cardiac Imaging and Diagnostics
- Prostate Cancer Treatment and Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Medical Image Segmentation Techniques
- Radiation Dose and Imaging
- HIV Research and Treatment
- Nicotinic Acetylcholine Receptors Study
- Thyroid Cancer Diagnosis and Treatment
- Receptor Mechanisms and Signaling
- Monoclonal and Polyclonal Antibodies Research
- Medical Imaging and Pathology Studies
- Immunotherapy and Immune Responses
- Parkinson's Disease Mechanisms and Treatments
- Immune Cell Function and Interaction
- Neuroscience and Neuropharmacology Research
- Sarcoma Diagnosis and Treatment
- Lung Cancer Diagnosis and Treatment
- Tryptophan and brain disorders
Second Affiliated Hospital of Zhejiang University
2025
Hebei Medical University
2025
Second Hospital of Hebei Medical University
2025
Royal Marsden NHS Foundation Trust
2014-2024
Johns Hopkins University
2015-2024
Johns Hopkins Medicine
2012-2024
Ocean University of China
2022-2024
The Affiliated Yongchuan Hospital of Chongqing Medical University
2024
Chongqing Medical University
2024
Sun Yat-sen University
2013-2023
Significance [ 11 C]CPPC [5-cyano- N -(4-(4-[ C]methylpiperazin-1-yl)-2-(piperidin-1-yl)phenyl)furan-2-carboxamide] is a PET radiotracer specific for CSF1R, microglia-specific marker. This compound can be used as noninvasive tool imaging of reactive microglia, disease-associated microglia and their contribution to neuroinflammation in vivo. Neuroinflammation posited an underlying pathogenic feature wide variety neuropsychiatric disorders. may also study specifically the immune environment...
Abstract Epstein–Barr virus (EBV) is implicated as an aetiological factor in B lymphomas and nasopharyngeal carcinoma. The mechanisms of cell-free EBV infection epithelial cells remain elusive. glycoprotein (gB) the critical fusion protein for both cells, determines susceptibility non-B cells. Here we show that neuropilin 1 (NRP1) directly interacts with gB 23–431 . Either knockdown NRP1 or pretreatment soluble suppresses infection. Upregulation by overexpression EGF treatment enhances...
By monitoring bone metastases with sequential [(18)F]fluorodeoxyglucose positron-emission tomography/computed tomography ([(18)F]FDG-PET/CT) imaging, this study investigates the clinical relevance of [(18)F]FDG uptake features various radiographic appearances.Bone were found in 67 408 consecutive patients known/suspected recurrent breast cancer on [(18)F]FDG-PET/CT, characterized by CT morphology changes and/or bony uptake. Twenty-five had [(18)F]FDG-PET/CT examinations (86 studies) over an...
Purpose: Yttrium‐90 ( 90 Y) is one of the most commonly used radionuclides in targeted radionuclide therapy (TRT). Since it decays with essentially no gamma photon emissions, surrogate (e.g., 111 In) or imaging agents 99m Tc MAA) are typically for treatment planning. It would, however, be useful to image Y directly order confirm that distributions measured these other same as labeled agents. As a result, there has been great deal interest quantitative bremsstrahlung photons using single...
PET targeting a mutated PSMA enabled serial imaging of CAR T cell activity in murine model ALL.
Abstract Cystatin SN (CST1) belongs to the type 2 cystatin (CST) superfamily, which restricts proteolytic activities of cysteine proteases. CST1 has been recently considered be involved in development several human cancers. However, prognostic significance and function breast cancer remains unknown. In current study, we found that was generally upregulated at both mRNA protein level. Furthermore, overall survival (OS) disease-free (DFS) low expression subgroup were significantly superior...
Automatic detection and characterization of cancer are important clinical needs to optimize early treatment. We developed a deep, semisupervised transfer learning approach for fully automated, whole-body tumor segmentation prognosis on PET/CT. <b>Methods:</b> This retrospective study consisted 611 <sup>18</sup>F-FDG PET/CT scans patients with lung cancer, melanoma, lymphoma, head neck breast 408 prostate-specific membrane antigen (PSMA) prostate cancer. The had nnU-net backbone learned the...
Blood transfusions were frequently in massive burn patients, current studies focus on the trigger threshold of red blood cell transfusion, and few impact transfusion volume patient outcomes. We initiated a multicenter cohort study to explore mortality. 379 patients three centers enrolled cohort. The extroperative overall RBC death group significantly higher than those survival (p < 0.001), this difference became insignificant within operation = 0.312). mortality risk was obviously not linear...
To investigate the diagnostic performance of (18)F-fludeoxyglucose ((18)F-FDG) positron emission tomography (PET)/CT in patients with suspected large-vessel vasculitis and its potential to evaluate extent activity disease.78 consecutive (mean age 63 years; 53 females) were evaluated (18)F-FDG PET/CT.( 18)F-FDG uptake aorta major branches was visually graded using a four-point scale quantified standardised values (SUV(max)). According clinical diagnosis, classified into three groups: (a)...
Significance EBV causes nasopharyngeal carcinoma (NPC), an endemic disease in southern China. Unlike infection of B lymphocytes, the molecular mechanisms and outcomes epithelial cells are poorly understood. In vitro, infects lymphoma Mo-MLV insertion region 1 homolog (BMI1)-immortalized (NPECs) poorly. We have now established a protocol to infect sphere-like derived from monolayer NPECs with EBV. Using this model system, we identified nonmuscle myosin heavy chain IIA (NMHC-IIA) as important...
Microwave image reconstruction based on a deep learning method is investigated in this article. The neural network capable of converting measured microwave signals acquired from 24 × antenna array at 4 GHz into 128 image. To reduce the training difficulty, we first developed an autoencoder by which high-resolution images (128 128) were represented with 256 1 vectors; then second aimed to map compressed features (256 vector). Two networks can be combined full make reconstructions, when both...
Despite viral suppression, HIV-associated cognitive impairment persists and may be partially due to persistent immune signalling by cells of the myeloid-lineage. Here, we aimed understand contribution activated microglia located in vulnerable brain regions (e.g. frontal, subcortical) HIV-infected, virally suppressed (HIV+VS) individuals relation motor function.Twenty-one HIV+VS underwent PET with [11C]DPA-713 image translocator protein 18 kDa (TSPO), a marker microglial activation, completed...
Interferon-stimulated gene 15 (ISG15), the first identified ubiquitin-like protein, is known for its anti-viral capacity. However, role in tumorigenesis remains controversial. Here, using RNA-seq profiling analysis, we ISG15 as a differentially expressed nasopharyngeal carcinoma (NPC) and validated overexpression NPC samples cells. High levels tissues were correlated with more frequent local recurrence shorter overall survival disease-free survival. promoted cancer stem cell phenotype cells,...
Glioblastoma multiforme (GBM) is the most aggressive and common type of brain cancer. Five-year survival rates are below 12%, even with trimodal therapies. Poor blood–brain barrier (BBB) permeability therapeutics a major obstacle to efficacy. Intravenous administration bevacizumab standard treatment for GBM. It has been recently demonstrated that single intraarterial infusion provides superior therapeutic outcomes in patients recurrent Further GBM benefits can be achieved through opening BBB...
The weak absorption of shortwave infrared light by skin tissues between 700 and 1500 nm offers an important window for diagnosis optical means. strong scattering the skin, however, presents a challenge to modelling propagation through understanding optics. We have measured collimated diffuse transmittance reflectance porcine dermis samples within 30 h post-mortem. Monte Carlo simulations been performed inversely determine coefficient, coefficient anisotropy factor in spectral range from 900...
Accurate estimation of the 3D in vivo activity distribution is important for dose targeted radionuclide therapy (TRT). Although SPECT can potentially provide such estimates, without compensation image degrading factors not quantitatively accurate. In this work, we evaluated quantitative (QSPECT) reconstruction methods that include various physical effects. Experimental projection data were obtained using a GE VH/Hawkeye system and an RSD torso phantom. Known activities In-111 chloride placed...