A5043713048- Head and Neck Cancer Studies
- Epigenetics and DNA Methylation
- Family and Disability Support Research
- Advanced Breast Cancer Therapies
- Palliative Care and End-of-Life Issues
- Dysphagia Assessment and Management
- Cancer-related gene regulation
- Childhood Cancer Survivors' Quality of Life
- Cleft Lip and Palate Research
- Oral Health Pathology and Treatment
- Clinical practice guidelines implementation
- Oral and Maxillofacial Pathology
- Chronic Disease Management Strategies
- PI3K/AKT/mTOR signaling in cancer
- Cancer-related Molecular Pathways
- Reading and Literacy Development
- Global Cancer Incidence and Screening
- Cancer Diagnosis and Treatment
- Estrogen and related hormone effects
- Linguistic, Cultural, and Literary Studies
- HER2/EGFR in Cancer Research
- Tracheal and airway disorders
- Respiratory viral infections research
- Infant Development and Preterm Care
- Cervical Cancer and HPV Research
Cardiff University
2020-2024
University of Bristol
2018-2022
NIHR Bristol Biomedical Research Centre
2018-2022
University Hospitals Bristol NHS Foundation Trust
2020-2021
University of Glasgow
2017-2021
National Institute for Health Research
2020-2021
University Of Bristol Dental Hospital
2020
Ninewells Hospital
2018
Public Health England
2018
Introduction Head and neck cancer appears to be increasing in incidence, with potential changes aetiology proposed. This paper aims provide a narrative overview of the epidemiological literature describe disease burden trends terms incidence mortality both UK globally review evidence on current risk factors.Methods A search was performed multiple databases (PubMed Epistemonikos), applying filters identify systematic reviews meta-analyses which investigated head factors. International...
Capivasertib, an AKT inhibitor, added to fulvestrant, was previously reported improve progression-free survival in women with aromatase inhibitor-resistant oestrogen receptor (ER)-positive, HER2-negative advanced breast cancer. The benefit appeared be independent of the phosphoinositide 3-kinase (PI3K)/AKT/phosphatase and tensin homologue (PTEN) pathway alteration status tumours, as ascertained using assays available at time. Here, we report updated overall results, a prespecified...
Abstract Background Epigenetic clocks are biomarkers of ageing derived from DNA methylation levels at a subset CpG sites. The difference between age predicted by these and chronological age, termed “epigenetic acceleration”, has been shown to predict age-related disease mortality. We aimed assess the prognostic value epigenetic acceleration methylation-based mortality risk score with all-cause in prospective clinical cohort individuals head neck cancer: Head Neck 5000. investigated two...
Background: Few large studies describe initial disease trajectories and subsequent mortality in people with head neck cancer. This is a necessary first step to identify the need for palliative care associated services. Aim: To analyse data from Head Neck 5000 study present mortality, place mode of death within 12 months diagnosis. Design: Prospective cohort study. Participants: In total, 5402 new diagnosis cancer were recruited 76 centres United Kingdom between April 2011 December 2014....
Epstein-Barr virus (EBV) causes nasopharyngeal carcinoma (NPC) in endemic regions, where almost every tumor is EBV-positive. In Western populations, NPC rare, and human papillomavirus infection (HPV) has been suggested as another viral cause. We validated multiplex serology with molecular markers, to define EBV-positive, HPV-positive EBV-/HPV-negative NPCs the United Kingdom, analyzed survival differences between those groups. Sera from cases (n = 98) age- sex-matched controls 142) Head Neck...
To assess how type and number of symptoms are related to survival in patients with head neck cancer.Patients were followed up for over 10 years from the Scottish Audit Head Neck Cancer (national cohort cancer Scotland 1999-2001). September 2013, was linked national mortality data. First, second third presenting recorded at diagnosis.National prospective audit-Scotland.A subset 1589 patients, original 1895, who had arising one four main subsites; larynx, oropharynx, oral cavity...
Abstract Background We investigated long‐term survival from head and neck cancer (HNC) using different approaches. Methods Patients were followed‐up the Scottish Audit of Head Neck Cancer. Overall disease‐specific calculated Kaplan–Meier method. Net was by Pohar‐Perme Mutually adjusted Cox proportional hazards models used to determine predictors survival. Results A total 1820 patients included in analyses. at 12 years 26.3% (24.3%, 28.3%). Disease‐specific 56.9% (54.3%, 59.4%). 41.4% (37.6%,...
Explanations for socioeconomic inequalities in survival of head and neck cancer (HNC) patients have had limited attention are not well understood.The UK Head Neck 5000 prospective clinical cohort study was analyzed. Survival relating to measures status explored including area-based individual factors. Three-year overall determined using the Kaplan-Meier method. All-cause mortality investigated via adjusted Cox Proportional Hazard models.A total 3440 people were included. 76.3% (95% CI 74.9,...
DNA methylation (DNAm) variation is an established predictor for several traits. In the context of oropharyngeal cancer (OPC), where 5-year survival ~ 65%, may act as a prognostic biomarker. We examined accuracy biomarkers 4 complex exposure traits (alcohol consumption, body mass index [BMI], educational attainment and smoking status) in predicting all-cause mortality people with OPC. DNAm predictors alcohol BMI, status were applied to 364 individuals OPC Head Neck 5000 cohort (HN5000; 19.6%...
Abstract Background Smoking status, alcohol consumption and HPV infection (acquired through sexual activity) are the predominant risk factors for oropharyngeal cancer thought to alter prognosis of disease. Here, we conducted single-site differentially methylated region (DMR) epigenome-wide association studies (EWAS) these factors, in addition ∼ 3-year survival, using Illumina Methylation EPIC DNA methylation profiles from whole blood 409 individuals as part Head Neck 5000 (HN5000) study....
Background: Socioeconomic inequalities impact on the survival of head and neck cancer patients, but there is limited understanding explanations inequality, particularly in long-term survival. Methods: Patients were recruited from Scottish Audit Head Neck 1999 to 2001 linked mortality data as at 30th September 2013. status was determined using area-based Carstairs index. Overall disease-specific calculated Kaplan-Meier method with 95% confidence intervals (CI’s) one-, five- 12-years. Cox...
Abstract Objectives This paper aims to provide contemporary epidemiological data on squamous cell carcinoma (SCC) of the nasal cavity, which represents a rare type head and neck cancer. Design, Setting & Participants A descriptive analysis people with cavity SCC treated curative intent from Head Neck 5000 study; multicentre clinical cohort study UK People tumours nasopharynx, paranasal sinuses other sub‐sites were excluded. Main outcome measures Demographic treatment details are...
Abstract Background Children with a learning disability experience range of inequalities and adverse life events that put them at greater risk mental health problems. The construct emotional literacy has been shown to be moderating factor how stress affects health. Teaching in schools may therefore an effective way promote positive There is identified need for adapted programmes special schools. Objectives To evaluate whether it feasible conduct large-scale randomised controlled trial the...
Abstract Background Four out of five people living with osteoarthritis (OA) also suffer at least one other long-term health condition. The complex interaction between OA and multiple conditions (MLTCs) can result in difficulties self-care, restricted mobility, pain, anxiety, depression reduced quality life. aim the MulTI-domain Self-management Older People wiTh OstEoarthritis Multi-Morbidities (TIPTOE) trial is to evaluate clinical cost-effectiveness Living Well self-management support...
ABSTRACT Background There is a paucity of research into interventions that help people with intellectual disabilities learn to read. This feasibility study examines whether an online reading programme, Headsprout, additional support strategies and supervision (the intervention), can be delivered by workers/family carers the conducting later large‐scale effectiveness trial. Methods The used 2‐arm randomised controlled trial (RCT) design embedded process evaluation using mixed methods...
Abstract Smoking status, alcohol consumption and HPV infection (acquired through sexual activity) are the predominant risk factors for oropharyngeal cancer thought to alter prognosis of disease. Here, we conduct epigenome-wide association studies (EWAS) these ∼3-year survival using Illumina Methylation EPIC blood DNA methylation profiles from 409 individuals in Head Neck 5000 (HN5000) study. CpG site associations below our multiple-testing threshold ( P Bonferroni < 0.05) with both a...
Abstract Background Single‐modality treatment (surgery or radiotherapy [RT]) is a curative option for early‐stage oropharyngeal carcinoma (OPC) with comparable (excellent) oncological outcomes. This study aimed to compare self‐reported swallowing function. Methods Participants T1‐2N0‐2bM0 OPC who were offered single‐modality and recruited the Head Neck 5000 included. Prospectively collected function was compared between surgery RT. Results Those RT (n = 150) had less favorable baseline...
Many individuals with intellectual disability (ID) have not learnt basic reading skills by the time that they reach adulthood, potentially limiting their access to critical information. READ-IT is an online programme developed from Headsprout® Early Reading (HER®) intervention and supplemented support strategies tailored for adults ID. HER® has been successfully used teach ID read in a forensic setting trained staff. The aim of this study assess feasibility delivering family carers/support...
Abstract Background Epigenetic clocks are biomarkers of ageing derived from DNA methylation levels at a subset CpG sites. The difference between predicted age these and chronological (“epigenetic acceleration”) has been shown to predict age-related disease mortality. We aimed assess the prognostic value epigenetic acceleration with all-cause mortality in prospective clinical cohort individuals head neck cancer: Head Neck 5000. Methods investigated two markers intrinsic ( IEAAHorvath...
Abstract Background FURVA, a randomised, double-blind Phase II trial, investigated whether the addition of vandetanib to fulvestrant improved progression-free survival (PFS) in patients with an aromatase inhibitor(AI)-resistant advanced breast cancer. Methods Postmenopausal women oestrogen receptor-positive (ER+ve)/HER2-negative cancer, who experienced disease progression on AI, were randomised (1:1) 500 mg (Q28) 300 od (f + v) or placebo p) until discontinuation. The primary endpoint was...
Human papillomavirus (HPV) is associated with survival in oropharyngeal cancer (OPC). We describe the prevalence of HPV antibodies and differences head neck 5000, a prospective clinical cohort 5,369 people diagnosed (HNC) UK from 2011 to 2014.
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