A5016488980- Prostate Cancer Treatment and Research
- Voice and Speech Disorders
- Dysphagia Assessment and Management
- Prostate Cancer Diagnosis and Treatment
- Head and Neck Cancer Studies
- Advanced Breast Cancer Therapies
- Tracheal and airway disorders
- Management of metastatic bone disease
- Cancer, Lipids, and Metabolism
- Cancer Treatment and Pharmacology
- HER2/EGFR in Cancer Research
- PARP inhibition in cancer therapy
- Sarcoma Diagnosis and Treatment
- Spine and Intervertebral Disc Pathology
- Advanced Radiotherapy Techniques
- Urologic and reproductive health conditions
- Breast Cancer Treatment Studies
- Testicular diseases and treatments
- Estrogen and related hormone effects
- Sexual Differentiation and Disorders
- Cancer Diagnosis and Treatment
- Effects of Radiation Exposure
- Lymphoma Diagnosis and Treatment
- Advances in Oncology and Radiotherapy
- Drug-Induced Ocular Toxicity
Ipswich Hospital
2012-2024
East Suffolk and North Essex NHS Foundation Trust
2020-2024
National Health Service
2007-2020
University Hospitals of Morecambe Bay NHS Foundation Trust
2019
Betsi Cadwaladr University Health Board
2019
Blackpool Teaching Hospitals NHS Foundation Trust
2019
The Christie NHS Foundation Trust
2019
Calderdale and Huddersfield NHS Foundation Trust
2019
Royal Marsden NHS Foundation Trust
2006-2015
University of Suffolk
2014
Capivasertib (AZD5363) is a potent selective oral inhibitor of all three isoforms the serine/threonine kinase AKT. The FAKTION trial investigated whether addition capivasertib to fulvestrant improved progression-free survival in patients with aromatase inhibitor-resistant advanced breast cancer.
in the epidemiology and clinical association of sickle cell disease with malaria, bacterial viral infections (including SARS-CoV-2), suggests that should be included Integrated Management Childhood Illness programme to improve outcomes.Provision for diagnosis treatment incorporated into national health systems programming, an emphasis on delivering services primary care setting.COVID-19 is expected herald a global economic recession might result contraction international funding development...
Capivasertib, an AKT inhibitor, added to fulvestrant, was previously reported improve progression-free survival in women with aromatase inhibitor-resistant oestrogen receptor (ER)-positive, HER2-negative advanced breast cancer. The benefit appeared be independent of the phosphoinositide 3-kinase (PI3K)/AKT/phosphatase and tensin homologue (PTEN) pathway alteration status tumours, as ascertained using assays available at time. Here, we report updated overall results, a prespecified...
Survival in stage I seminoma is almost 100%. Computed tomography (CT) surveillance an international standard of care, avoiding adjuvant therapy. In this young population, minimizing irradiation vital. The Trial Imaging and Surveillance Seminoma Testis (TRISST) assessed whether magnetic resonance images (MRIs) or a reduced scan schedule could be used without unacceptable increase advanced relapses.A phase III, noninferiority, factorial trial. Eligible participants had undergone orchiectomy...
PARTNER is a prospective, phase II-III, randomized controlled clinical trial that recruited patients with triple-negative breast cancer
To evaluate the prostate-specific antigen (PSA) response rate and duration of PSA to dexamethasone in patients with castration-refractory prostate cancer (CRPC), as corticosteroids are frequently used second-line hormonal treatment CRPC there is little published evidence concerning efficacy low-dose this setting.In all, 102 progressive received oral (0.5 mg daily) between January 2003 October 2006. The median pretreatment level was 83 ng/mL. main endpoint according Working Group criteria.In...
PurposeTo establish the toxicity profile of high-dose pelvic lymph node intensity-modulated radiation therapy (IMRT) and to assess whether it is safely deliverable at multiple centers.Methods MaterialsIn this phase 2 noncomparative multicenter trial, 124 patients with locally advanced, high-risk prostate cancer were randomized between prostate-only IMRT (PO) (74 Gy/37 fractions) (P&P; 74 fractions prostate, 60 pelvis). The primary endpoint was acute lower gastrointestinal (GI) Radiation...
<h3>Importance</h3> Patients with breast cancer remain at risk of relapse after adjuvant therapy. Celecoxib has shown antitumor effects in preclinical models human cancer, but clinical evidence is lacking. <h3>Objective</h3> To evaluate the role celecoxib as an addition to conventional therapy for women ERBB2 (formerly HER2)–negative primary cancer. <h3>Design, Setting, and Participants</h3> The Randomized European Trial (REACT) was a phase 3, randomized, double-blind study conducted 160...
1005 Background: The PI3K/AKT signalling pathway is frequently activated in patients (pts) with estrogen receptor (ER) positive breast cancer (ER+BC) and has been implicated endocrine therapy resistance. Capivasertib (AZD5363) a highly-selective, oral, small molecule AKT inhibitor. FAKTION trial investigated the addition of capivasertib to fulvestrant for postmenopausal women ER+ HER2 negative BC after relapse or disease progression on an aromatase inhibitor (AI). Methods: investigator-led,...
<h3>Purpose</h3> Hypofractionated radiation therapy can be used to treat patients with muscle-invasive bladder cancer unable have radical therapy. Toxicity is a key concern, but adaptive plan-of the day (POD) image-guided delivery could improve outcomes by minimizing volume of normal tissue irradiated. The HYBRID trial assessed multicenter implementation, safety, and efficacy this strategy. <h3>Methods</h3> Phase II randomized that was conducted at 14 UK hospitals. Patients T2-T4aN0M0...
Active surveillance for early prostate cancer is a policy of close monitoring with radical treatment targeted at cases evidence disease progression. There no consensus on the need or optimum timing repeat biopsies as part active surveillance.In prospective cohort study 119 patients untreated localized (T1/2a), specific antigen less than 15 ng/ml, Gleason score 3 + 4 and 50% positive cores underwent biopsy after 18 to 24 months. Histological progression was defined primary grade greater,...
The coronavirus disease-2019 (COVID-19) pandemic has had a significant impact on patients with underlying malignancy. In this article, we summarize emerging data related to cancer and COVID-19. Among COVID-19, higher proportion have an diagnosis of than seen in the general population. Also, malignancy are likely be more vulnerable population contracting Mortality is significantly both COVID-19 compared overall COVID-19-positive early months saw decrease screening diagnosis, as well...
OBJECTIVE To evaluate the utility of lactate dehydrogenase (LDH), a tumour marker that is frequently elevated at diagnosis and relapse testicular germ cell tumours (TGCTs), in follow‐up TGCTs for detecting relapse, as it has role prognostic factor but its less certain. PATIENTS AND METHODS We retrospectively reviewed 499 patients with TGCT who were followed from 1 January 2004 to 31 December 2005, no clinical evidence disease after complete response treatment or on surveillance stage I...
Abstract Introduction The diagnosis and quantification of chemotherapy‐induced peripheral neuropathy ( CIPN ) remains a challenge. Conventional methods including quantitative sensory testing QST ), nerve conduction tests, biopsy are unable to detect subclinical changes, do not consistently correlate with severity patients' symptoms functional impairment. This study aims determine the utility LDI (laser Doppler imager) FLARE technique in whether it correlates symptom severity. Materials...
The consequences of a diagnosis head and neck cancer the impact treatment have clear direct influence on well-being associated quality life (QOL) in these patients.To determine QOL patients following partial glossectomy operation.Cross-sectional cohort study; Head Neck Oncology Unit, tertiary referral center.38 with were assessed University Washington (UW-QOL) scale, version 4.Statistical analysis was performed using Statistical Package for Social Sciences 10.0 (SPSS Inc, Chicago III)....
Extraskeletal Ewings sarcoma are rare tumors for which there is no consensus on optimal management.A retrospective review of the clinical features, treatment and outcome patients with extraskeletal who reported to a single institution between January 1992-December 2003 reported.A total 19 were identified. Of these, 4 had metastatic disease at presentation 15 non-metastatic received combined modality primary combination chemotherapy followed by local radiotherapy or surgery. Disease free...
To determine the quality of life (QOL) in patients using valved speech following total laryngectomy with a validated patient self-report scale.Cross-sectional cohort study.63 speech.University Washington Quality Life (UW-QOL) questionnaire.Patient perception QOL over last 7 days response to specific questions and correlated sociodemographic treatment factors.Responses were received from 44 males 11 females (response rate: 87.3%) median age 66 years (range: 40-84). The mean (SD) composite...
To determine the effects of a partial/total glossectomy on swallow-related quality life (QOL).Cross-sectional, single-centre cohort study.Thirty-one patients who underwent at our centre participated in study. Main outcome was measured using MD Andersen Dysphagia Inventory (MDADI) questionnaire.Responses were received from 24 males and 7 females (response rate 77.5%) with median age 50 years (range: 28-72). Median follow-up 33 months (range 4-210). The mean MDADI total score series 71.7 (SD...
Objective: The objective of this study was to undertake a multidimensional assessment female tracheoesophageal prosthetic speech. Study Design: A cross‐sectional cohort study. Setting: Head and Neck Unit in tertiary oncology referral centre. Patients: Ten 10 male total laryngectomy patients with no signs recurrence using voice prosthesis were compared normal speakers. Intervention(s): Electroglottographic acoustic analysis parameters for both sustained vowel /i/ connected speech, perceptual...