A5001697814- Prostate Cancer Treatment and Research
- Prostate Cancer Diagnosis and Treatment
- Bladder and Urothelial Cancer Treatments
- Genital Health and Disease
- Urological Disorders and Treatments
- Urinary and Genital Oncology Studies
- Urologic and reproductive health conditions
- Advanced Radiotherapy Techniques
- BRCA gene mutations in cancer
- Radiomics and Machine Learning in Medical Imaging
- Endometrial and Cervical Cancer Treatments
- Sexual function and dysfunction studies
- Cancer Genomics and Diagnostics
- Renal cell carcinoma treatment
- Cancer and Skin Lesions
- Radiation Therapy and Dosimetry
- Uterine Myomas and Treatments
- Lung Cancer Diagnosis and Treatment
- Management of metastatic bone disease
- Statistical Methods in Clinical Trials
- Advances in Oncology and Radiotherapy
- Effects of Radiation Exposure
- MRI in cancer diagnosis
- Cervical Cancer and HPV Research
- Ethics and Legal Issues in Pediatric Healthcare
University College London Hospitals NHS Foundation Trust
2016-2025
University College London
2016-2025
Centre Hospitalier Universitaire de Lille
2023
Université de Lille
2023
Royal London Hospital
2016-2021
University College Hospital
2006-2021
Institute of Cancer Research
2007-2017
National Health Service
2016
Cancer Institute (WIA)
2016
Royal Marsden NHS Foundation Trust
2007-2010
The magnetic resonance (MR) images of 14 wrists patients with carpal tunnel syndrome (CTS) were studied. Four general findings visible regardless the cause CTS included swelling median nerve, best evaluated at level pisiform bone; flattening most reliably judged hamate level; palmar bowing flexor retinaculum, visualized and increased signal intensity nerve on T2-weighted images. Findings related to tendon sheath edema in traumatic tenosynovitis, synovial hypertrophy rheumatoid a ganglion...
Active surveillance (AS) is recommended for low-risk and some intermediate-risk prostate cancer. Uptake practice of AS vary significantly across different settings, as does the experience surveillance-from which tests are offered, to levels psychological support.To explore current best determine most important research priorities in cancer.A formal consensus process was followed, with an international expert panel purposively sampled participants a range health care professionals...
To test the hypothesis that, in a matched series of prostatic cancers, either with or without BRCA1 BRCA2 mutations, RAD51 protein expression is enhanced association BRCA mutation genotypes.RAD51 identified immunohistochemically was compared between cancers occurring carriers and controls. cytoplasm nuclei benign tissues significantly less than malignant (P < 0.001). In all cytoplasmic more prevalent associated higher Gleason score 0.05) irrespective mutational status, its Although nuclear...
Background Microseminoprotein-beta (MSMB) regulates apoptosis and using genome-wide association studies the rs10993994 single nucleotide polymorphism in MSMB promoter has been linked to an increased risk of developing prostate cancer. The location allele, its ability reduce activity, suggested that allele could result lowered benign tissue leading cancer risk. Methodology/Principal Findings expression malignant was examined immunohistochemistry compared with genotype. Urinary concentrations...
The role of multiparametric magnetic resonance imaging (MRI) for detecting recurrent prostate cancer after radiotherapy is unclear. To evaluate MRI and MRI-targeted biopsies intraprostatic recurrence planning salvage focal ablation. FOcal RECurrent Assessment Salvage Treatment (FORECAST; NCT01883128) was a prospective cohort diagnostic study that recruited 181 patients with suspected radiorecurrence at six UK centres (2014 to 2018); 144 were included here. All underwent 5 mm transperineal...
<h3>Purpose</h3> Hypofractionated radiation therapy can be used to treat patients with muscle-invasive bladder cancer unable have radical therapy. Toxicity is a key concern, but adaptive plan-of the day (POD) image-guided delivery could improve outcomes by minimizing volume of normal tissue irradiated. The HYBRID trial assessed multicenter implementation, safety, and efficacy this strategy. <h3>Methods</h3> Phase II randomized that was conducted at 14 UK hospitals. Patients T2-T4aN0M0...
Introduction Daily radiotherapy delivered with radiosensitisation offers patients muscle invasive bladder cancer (MIBC) comparable outcomes to cystectomy functional organ preservation. Most recurrences following occur within the bladder. Increasing dose tumour may further improve local control. Developments in image-guided have allowed tumour-focused ‘plan of day’ delivery. We aim test a randomised multicentre phase II trial whether this technique will enable escalation acceptable rates...
83 Background: Darolutamide has authorisation for treatment of non-metastatic Castrate Resistant Prostate Cancer (nmCRPC) based on the ARAMIS trial. The RECORD Study is a prospective real-world evaluation (RWE) clinical outcomes in patients with nmCRPC treated darolutamide UK. study will improve understanding response and duration as well inform regarding use next generation imaging (NGI) effects concomitant medication. Methods: Patients were enrolled from 19 centres over 3-year period...
InPACT addresses the optimal management of locally advanced penile cancer, aiming to prospectively evaluate relative benefits and sequencing surgery, chemotherapy, chemoradiotherapy. At trial inception, radiotherapy protocols for this rare cancer lacked consistency standardisation, necessitating multi-centre, international collaboration develop comprehensive Radiotherapy Planning, Delivery Quality Assurance Guidelines. has two main aims; establish efficacy neoadjuvant chemotherapy or...
Recurrent prostate cancer after radiotherapy occurs in one five patients. The efficacy of magnetic resonance imaging (MRI) recurrent has not been established. Furthermore, high-quality data on new minimally invasive salvage focal ablative treatments are needed. To evaluate the role MRI detection recurring and ablation treating disease. FORECAST trial was both a paired-cohort diagnostic study evaluating multiparametric (mpMRI) MRI-targeted biopsies cohort at six UK centres. A total 181...
Abstract Penile cancer (PeCa) is rare, and the oncological outcomes in younger men are unclear. We aimed to analyse compare of age ≤50 years (y) >50 with PeCa. A retrospective analysis y penile squamous cell carcinoma managed at a tertiary centre was performed. propensity score matched cohort identified for comparison. Matching according tumour, nodal stage types primary surgery. Overall survival (OS), disease-specific (DSS), recurrence-free (RFS), metastasis-free survivals (MFS) were...
This is a feasibility study to determine whether circulating tumour cells (CTCs) are detectable and suitable for molecular profiling in advanced endometrial cancer (aEC).Between October 2012 February 2014, 30 patients with aEC had baseline up 3 follow-up samples. CTCs stathmin expression were evaluated using the CellSearch platform. Epithelial cell adhesion molecule (EpCAM) immunohistochemistry performed on FFPE tissue.Eighteen from (60%) during [1 CTC (n = 7), 2 4), 1), 4 2), 7 8 22 172 1)...
Dutasteride, which is licensed for symptomatic benign prostatic hyperplasia, has been associated with a lower progression rate of low risk prostate cancer. We evaluated the effect dutasteride on cancer volume as assessed by T2-weighted magnetic resonance imaging.In this randomized, double-blind, placebo controlled trial, men biopsy proven, low-intermediate (up to Gleason 3 + 4 and PSA up 15 ng/ml) who had visible lesion 0.2 ml or greater imaging sequences were randomized daily 0.5 mg 6...
Our objectives were to assess the safety and clinical impact of a novel, kit-based formulation <sup>68</sup>Ga-tris(hydroxypyridinone) (<sup>68</sup>Ga-THP) prostate-specific membrane antigen (PSMA) for PET/CT in guiding management patients with prostate cancer. <b>Methods:</b> Patients prospectively recruited group A (high-risk untreated cancer; Gleason score ≥ 4 + 3, or (PSA) level > 20 ng/mL stage T2c), B (biochemical recurrence eligible salvage treatment after radical prostatectomy 2...
Penile cancer patients with advanced metastatic disease in the inguinal region present a therapeutic challenge. We compared outcomes for node requiring myocutaneous flap reconstruction (MFR) against primary closure N3 disease.A retrospective comparative study of consecutive cohort penile was performed. Patient demographics, presenting symptoms, tumour site, stage and grade were recorded. The type MFR used, patient post-operative complications recorded from an institutional database....
4514 Background: Platinum-based combination chemotherapy regimens are active in the treatment of penis cancer, but toxicity limits their value for patients with metastatic disease. VinCaP aims to define both and disease control rate non-platinum cytotoxic agent Vinflunine. Methods: A phase II single-arm trial was conducted. Eligible had measurable, histologically-proven squamous cell carcinoma (SCC) penis, staged M1; or M0,Tx,N3; M0,Tx,N2 deemed inoperable by multidisciplinary team; M0, T4...
Abstract Objective Increased risk of prostate cancer (PCa) is observed in men with BRCA1/BRCA2 mutations. Sex and gender are key determinants health disease although unequal care exists between the sexes. Stereotypical male attitudes shown to lead poor outcomes. Methods Men BRCA1/2 mutations diagnosed PCa were identified invited participate a qualitative interview study. Data analysed using framework approach. “Masculinity theory” was used report impact having both mutation PCa. Results...