A5036820514- Testicular diseases and treatments
- Prostate Cancer Treatment and Research
- Sarcoma Diagnosis and Treatment
- Hormonal and reproductive studies
- Inflammatory mediators and NSAID effects
- Neuroblastoma Research and Treatments
- Gastric Cancer Management and Outcomes
- Estrogen and related hormone effects
- Ovarian cancer diagnosis and treatment
- Statistical Methods in Clinical Trials
- Colorectal Cancer Screening and Detection
- Cancer, Lipids, and Metabolism
- Urologic and reproductive health conditions
- Global Cancer Incidence and Screening
- Ethics in Clinical Research
- Antiplatelet Therapy and Cardiovascular Diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Bone health and treatments
- Prostate Cancer Diagnosis and Treatment
- Cardiac Structural Anomalies and Repair
- Breast Cancer Treatment Studies
- Mechanical Circulatory Support Devices
- Asthma and respiratory diseases
- Genetic factors in colorectal cancer
- Bladder and Urothelial Cancer Treatments
Medical Research Council
2011-2024
MRC Clinical Trials Unit at UCL
2013-2024
University College London
2015-2024
Institute of Cancer Research
2022-2024
University of Central Lancashire
2024
Lancashire Teaching Hospitals NHS Foundation Trust
2024
Beatson West of Scotland Cancer Centre
2024
University of Glasgow
2024
Florey Institute of Neuroscience and Mental Health
2022
The University of Melbourne
2022
The classification of the International Germ Cell Cancer Collaborative Group (IGCCCG) plays a pivotal role in management metastatic germ cell tumors but relies on data patients treated between 1975 and 1990.Data 9,728 men with nonseminomatous cisplatin- etoposide-based first-line chemotherapy 1990 2013 were collected from 30 institutions or collaborative groups Europe, North America, Australia. Clinical trial registry included. Primary end points progression-free survival (PFS) overall (OS)....
The classification of the International Germ-Cell Cancer Collaborative Group (IGCCCG) has been a major advance in management germ-cell tumors, but relies on data only 660 patients with seminoma treated between 1975 and 1990. We re-evaluated this database from large international consortium.Data 2,451 men metastatic cisplatin- etoposide-based first-line chemotherapy 1990 2013 were collected 30 institutions or collaborative groups Australia, Europe, North America. Clinical trial registry...
Clinical trials frequently include multiple end points that mature at different times. The initial report, typically based on the primary point, may be published when key planned co-primary or secondary analyses are not yet available. Trial Updates provide an opportunity to disseminate additional results from studies, in JCO elsewhere, for which point has already been reported. POUT was a phase III, randomized, open-label trial, including 261 patients with muscle-invasive lymph...
Determination of survival time among persons with screen-detected cancer is subject to lead and length biases. The authors propose a simple correction for time, assuming an exponential distribution the preclinical screen-detectable period. Assuming two latent categories tumors, one which more prone screen detection correspondingly less death from in question, have developed strategy sensitivity analysis various magnitudes bias. Here they demonstrate these methods using series 25,962 breast...
There is a considerable body of pre-clinical, epidemiological and randomised data to support the hypothesis that aspirin has potential be an effective adjuvant cancer therapy.
To establish the performance characteristics of annual transvaginal ultrasound and serum CA125 screening for women at high risk ovarian/fallopian tube cancer (OC/FTC) to investigate impact delayed interval surgical intervention.Between May 6, 2002, January 5, 2008, 3,563 an estimated ≥ 10% lifetime OC/FTC were recruited screened by 37 centers in United Kingdom. Participants observed prospectively centers, questionnaire, national registries.Sensitivity detection incident 1 year after last...
Survival in stage I seminoma is almost 100%. Computed tomography (CT) surveillance an international standard of care, avoiding adjuvant therapy. In this young population, minimizing irradiation vital. The Trial Imaging and Surveillance Seminoma Testis (TRISST) assessed whether magnetic resonance images (MRIs) or a reduced scan schedule could be used without unacceptable increase advanced relapses.A phase III, noninferiority, factorial trial. Eligible participants had undergone orchiectomy...
Luteinising-hormone-releasing-hormone agonists (LHRHa) to treat prostate cancer are associated with long-term toxic effects, including osteoporosis. Use of parenteral oestrogen could avoid the complications LHRHa and thromboembolic oral oestrogen.In this multicentre, open-label, randomised, phase 2 trial, we enrolled men locally advanced or metastatic scheduled start indefinite hormone therapy. Randomisation was by minimisation, in a 2:1 ratio, four self-administered patches (100 μg per 24...
There is real need to change how we do some of our clinical trials, as currently the testing and development process too slow, costly failure-prone often find that a new treatment no better than current standard. Much focus on pathway has been in improving design phase I II trials. In this article, present examples methods for III trials (and necessary lead up them) they are most time-consuming expensive part pathway. Key all these aim test many treatments and/or pose therapeutic questions...
Pre-clinical models demonstrate that platelet activation is involved in the spread of malignancy. Ongoing clinical trials are assessing whether aspirin, which inhibits activation, can prevent or delay metastases.
Background— It is presumed that stentless aortic bioprostheses are hemodynamically superior to stented bioprostheses. A prospective randomized controlled trial was undertaken compare versus modern valves. Methods and Results— Patients with severe valve stenosis (n=161) undergoing replacement (AVR) were intraoperatively receive either the C-E Perimount bioprosthesis (n=81) or Prima Plus (n =80). We assessed left ventricular mass (LVM) regression transthoracic echocardiography (TTE) magnetic...
Objectives To compare quality‐of‐life (QoL) outcomes at 6 months between men with advanced prostate cancer receiving either transdermal oestradiol ( tE 2) or luteinising hormone‐releasing hormone agonists LHRH a) for androgen‐deprivation therapy ADT ). Patients and methods Men locally metastatic participating in an ongoing randomised, multicentre UK trial comparing 2 versus a were enrolled into QoL sub‐study. was delivered via three four transcutaneous patches containing 100 μg/24 h....
Routinely collected electronic health records (EHRs) have the potential to enhance randomised controlled trials (RCTs) by facilitating recruitment and follow-up. Despite this, current EHR use is minimal in UK RCTs, part due ongoing concerns about utility (reliability, completeness, accuracy) accessibility of data. The aim this manuscript document process, timelines challenges application process help improve service both for applicants data holders.