Richard Adams
A5017956085- Colorectal Cancer Treatments and Studies
- Colorectal and Anal Carcinomas
- Gastric Cancer Management and Outcomes
- Colorectal Cancer Surgical Treatments
- Cancer Genomics and Diagnostics
- Cancer Treatment and Pharmacology
- Genetic factors in colorectal cancer
- Lung Cancer Treatments and Mutations
- Radiomics and Machine Learning in Medical Imaging
- Hepatocellular Carcinoma Treatment and Prognosis
- Colorectal Cancer Screening and Detection
- Cancer Immunotherapy and Biomarkers
- Pancreatic and Hepatic Oncology Research
- Advanced Radiotherapy Techniques
- COVID-19 Clinical Research Studies
- Disability Rights and Representation
- Cancer survivorship and care
- Nonlinear Partial Differential Equations
- Advanced Mathematical Modeling in Engineering
- Immunotherapy and Immune Responses
- Cardiac Health and Mental Health
- Health Systems, Economic Evaluations, Quality of Life
- Virus-based gene therapy research
- RNA Interference and Gene Delivery
- Delphi Technique in Research
Cardiff University
2016-2025
Velindre Cancer Centre
2015-2024
Velindre NHS Trust
2014-2024
National Heart Lung and Blood Institute
2024
National Institutes of Health
2024
Southeast Georgia Health System
2024
National Health Service Wales
2020-2024
University Hospital of Wales
2017-2023
Columbia University
2004-2022
MRC Clinical Trials Unit at UCL
2013-2022
BackgroundMany patients with COVID-19 have been treated plasma containing anti-SARS-CoV-2 antibodies. We aimed to evaluate the safety and efficacy of convalescent therapy in admitted hospital COVID-19.MethodsThis randomised, controlled, open-label, platform trial (Randomised Evaluation Therapy [RECOVERY]) is assessing several possible treatments hospitalised UK. The underway at 177 NHS hospitals from across Eligible consenting were randomly assigned (1:1) receive either usual care alone...
Data suggest selective internal radiotherapy (SIRT) in third-line or subsequent therapy for metastatic colorectal cancer has clinical benefit patients with liver metastases liver-dominant disease after chemotherapy. The FOXFIRE, SIRFLOX, and FOXFIRE-Global randomised studies evaluated the efficacy of combining first-line chemotherapy SIRT using yttrium-90 resin microspheres metastases. were designed combined analysis overall survival.
BackgroundAspirin has been proposed as a treatment for COVID-19 on the basis of its anti-thrombotic properties. We aimed to evaluate efficacy and safety aspirin in patients admitted hospital with COVID-19.MethodsIn this randomised, controlled, open-label, platform trial, several possible treatments were compared usual care hospitalised COVID-19. The trial took place at 177 hospitals UK, two Indonesia, Nepal. Eligible consenting adults randomly allocated 1:1 ratio either standard plus 150 mg...
When cure is impossible, cancer treatment should focus on both length and quality of life. Maximisation time without toxic effects could be one effective strategy to achieve these goals. The COIN trial assessed preplanned holidays in advanced colorectal this aim.
BackgroundRadical surgery via total mesorectal excision might not be the optimal first-line treatment for early-stage rectal cancer. An organ-preserving strategy with selective could reduce adverse effects of without substantially compromising oncological outcomes. We investigated feasibility recruiting patients to a randomised trial comparing an excision.MethodsTREC was randomised, open-label study done at 21 tertiary referral centres in UK. Eligible participants were aged 18 years or older...
Abstract Clinical recommendations for Acute Myeloid Leukemia (AML) classification and risk-stratification remain heavily reliant on cytogenetic findings at diagnosis, which are present in <50% of patients. Using comprehensive molecular profiling data from 3,653 patients we characterize validate 16 classes describing 100% AML Each class represents diverse biological subgroups, is associated with distinct clinical presentation, likelihood response to induction chemotherapy, risk relapse...
BackgroundLow-dose corticosteroids have been shown to reduce mortality for patients with COVID-19 requiring oxygen or ventilatory support (non-invasive mechanical ventilation, invasive extracorporeal membrane oxygenation). We evaluated the use of a higher dose in this patient group.MethodsThis randomised, controlled, open-label platform trial (Randomised Evaluation Therapy [RECOVERY]) is assessing multiple possible treatments hospitalised COVID-19. Eligible and consenting adult clinical...
Acknowledgments. Editors' Introduction (Rachel Adams and David Savran) Part I: Eroticism. Introduction. 1. Some Psychological Consequences of the Anatomical Distinction between Sexes (Sigmund Freud) 2. Masochism Male Subjectivity (Kaja Silverman) 3. Subject Honor, Object Shame (Roger Lancaster) 4. The Democratic Body: Prostitution Citizenship in Classical Athens (David Halperin) II: Social Sciences. 5. Deep Play: Notes on Balinese Cockfight (Clifford Geertz) 6. Toward a New Sociology...
In recent retrospective analyses of early-stage colorectal cancer (CRC), low and high body mass index (BMI) scores were associated with worsened outcomes. Whether BMI is a prognostic or predictive factor in metastatic CRC (mCRC) unclear.
Abstract Purpose: Anticancer T-cell responses can control tumors, but immunosuppressive mechanisms in vivo prevent their function. The role of regulatory T cells (Tregs) metastatic colorectal cancer is unclear. We have previously shown depletion Tregs enhances cancer–specific effector responses. Low-dose cyclophosphamide targets animal models and some human studies; however, the effect unknown. Experimental Design: Fifty-five patients with were enrolled a phase I/II trial randomly assigned...
A definition of rectal cancer is important for optimal planning neoadjuvant therapy and surgical strategy. Anatomically the rectum distal to sigmoid colon its upper limit termination mesocolon. commonly used an adenocarcinoma with a margin at or below 15 cm from anal verge, measured by rigid sigmoidoscopy. Standard anatomical texts put this level third sacral vertebra (Williams & Warwick, 1980) but it generally agreed surgeons that starts promontory (UKCCCR, 1989). Whilst there remains...
Estimating prognosis on the basis of clinicopathologic factors can inform clinical practice and improve risk stratification for trials. We constructed prognostic nomograms one-year overall survival six-month progression-free in metastatic colorectal carcinoma by using ARCAD database. Data from 22 674 patients 26 randomized phase III trials since 1997 were used to construct validate Cox models, stratified treatment arm within each study. Candidate variables included baseline age, sex, body...
Advanced colorectal cancer is treated with a combination of cytotoxic drugs and targeted treatments. However, how best to minimise the time spent taking whether molecular selection can refine this further unknown. The primary aim study was establish cetuximab might be safely effectively added intermittent chemotherapy.
To compare cisplatin plus fluorouracil (FU) versus carboplatin paclitaxel in chemotherapy-naïve advanced anal cancer to establish the optimal regimen.