A5056566819- Cancer Genomics and Diagnostics
- Sarcoma Diagnosis and Treatment
- Genetic factors in colorectal cancer
- Hematopoietic Stem Cell Transplantation
- Thermochemical Biomass Conversion Processes
- Immune Cell Function and Interaction
- Hepatocellular Carcinoma Treatment and Prognosis
- Analytical Chemistry and Chromatography
- Advanced ceramic materials synthesis
- Rocket and propulsion systems research
- Renal and related cancers
- Renal cell carcinoma treatment
- Analytical Methods in Pharmaceuticals
- Genomics and Rare Diseases
- Machine Learning in Healthcare
- Chromosomal and Genetic Variations
- Pharmaceutical studies and practices
- Machine Learning in Materials Science
- Robotic Mechanisms and Dynamics
- Dementia and Cognitive Impairment Research
- Molecular Biology Techniques and Applications
- HVDC Systems and Fault Protection
- Colorectal Cancer Treatments and Studies
- Agricultural Engineering and Mechanization
- Wireless Sensor Networks for Data Analysis
Slovak University of Technology in Bratislava
2011-2024
Institute of Environmental Engineering
2022
University Hospital Bratislava
2020
Slovak Medical University
2020
Comenius University Bratislava
2020
Czech Academy of Sciences, Institute of Mathematics
2015-2019
Abstract Osteosarcomas are aggressive bone tumours with a high degree of genetic heterogeneity, which has historically complicated driver gene discovery. Here we sequence exomes 31 and decipher their evolutionary landscape by inferring clonality the individual mutation events. Exome findings interpreted in context SNP array data from replication set 92 tumours. We identify 14 genes as main drivers, some were formerly unknown osteosarcoma. None drivers is clearly responsible for majority even...
Abstract Papillary renal cell carcinoma (pRCC) is an important subtype of kidney cancer with a problematic pathological classification and highly variable clinical behaviour. Here we sequence the genomes or exomes 31 pRCCs, in four tumours, multi-region sequencing undertaken. We identify BAP1 , SETD2 ARID2 Nrf2 pathway genes ( KEAP1 NHE2L2 CUL3 ) as probable drivers, together at least eight other possible drivers. However, only ~10% tumours harbour detectable pathogenic changes any one...
Flexural strength, hardness, and fracture toughness are the basic mechanical properties of ceramic materials. Manufacturers widely use this set to ensure durability products. However, many factors, such as chemical phase compositions, sintering temperature, average grain size, density, others, affect these properties, making it challenging estimate corresponding reliability parameters correctly. Experimental examination impact factors on ceramics is a rather time-consuming resource-consuming...
Mild Cognitive Impairment (MCI) is a condition characterized by decline in cognitive abilities, specifically memory, language, and attention, that beyond what expected due to normal aging. Detection of MCI crucial for providing appropriate interventions slowing down the progression dementia. There are several automated predictive algorithms prediction using time-to-event data, but it not clear which best predict time conversion MCI. also confusion if with fewer training weights less...
Roebel cables are a promising solution for high current, low AC loss made of high-temperature superconductors in the form coated conductors. High current creates significant self-field, which influences superconductor's current-carrying capability. In this paper, we investigate influence self-field on cable's critical and repartition among different strands. order to analysed flux creep cable properties. Using experimental material's properties derived from measurements single conductor as...
Osteosarcomas are aggressive primary tumors of bone that typically detected in locally advanced stages; however, which genetic mutations drive the cancer before its clinical detection remain unknown. To identify these events, we performed longitudinal genome-sequencing analysis 12 patients with metastatic or refractory osteosarcoma. Phylogenetic and molecular clock analyses were carried out next to actionable mutations, validated by integrating data from additional 153 osteosarcomas...
The present article aims to determine how the change in pH affects adsorption efficiency of pharmaceuticals on adsorbents.Natural zeolites various fractions and activated carbon (granular, powdered) were used as suitable available adsorbents.A total 102 drugs detected at outflow from Devínska Nová Ves wastewater treatment plant (WWTP), their concentration was 12.2 µg/l.The results first test (pH = 7.0) show that highest removal drug observed powdered (PAC > 99%).On other hand, achieved only...
The quality of a high-grade solid biofuel depends on many factors, which can be divided into three main groups - material, technological and structural. focus this paper is observing the influence structural parameters in biomass densification process. goal to model various options for geometry pressing chamber these briquettes. We will provide mathematical description whole physical process densifying particular material extruding it through cylindrical conical chamber. have used basic...
The process of disintegration is affected by a large number operating and design parameters which have not previously been described in detail. This paper discusses the effect disintegrative surface area on size operational load machine. parameter affects power device. explains experimental process, describes evaluates measured data with mathematical functions that describe relation devices to selected parameter.
Background Although considerable effort has been put into decoding of the osteosarcoma genome, very little is known about germline mutations that underlie this primary malignant tumour bone. Methods and results We followed here a coincidental finding in multiple endocrine neoplasia family which 32-year-old patient carrying pathogenic RET mutation developed an 2 years after resection medullary thyroid carcinoma. Sequencing analysis additional 336 patients with led to identification activating...
Particulate matter from biomass, e.g. wood sawdust, is very diverse. The basic parameter describing the densification process of particulate its compressibility, quantified by coefficient compressibility. Knowing this for a specific material prerequisite application compressibility equations process, and calculating workload in production high-grade solid biofuel. This paper deals with methodology determining factor sawdust on basis experiments to quantify pine sawdust. were performed two...
The aim of this paper is to present some preliminary results from experimental research on the densification process solid high-grade biofuels. findings presented in contribute an investigation stabilization time, which important parameter process. During process, various parameters are pressing chamber machine, and each these influences time briquette. This (procedure) very important, because briquette can change dimensions weight throughout reflect negatively resulting presents effects...
Abstract In the recent years, new molecular methods have been proposed to discriminate multicentric hepatocellular carcinomas (HCC) from intrahepatic metastases. Some of these utilize sequencing data assess similarities between cancer genomes, whilst other achieved same results with transcriptome and methylome data. Here, we attempt classify two HCC patients multi-centric disease using recall-rates somatic mutations but find that difficult because their tumors share some chromosome-scale...
Allogeneic hematopoietic stem cell transplantation (alloHSCT) is a substantial therapeutic procedure for the treatment of wide spectrum severe diseases. Despite advancements in and supportive care, alloHSCT still carries considerable mortality risk, primarily caused by graft-versus-host disease (GvHD). Our retrospective analysis aimed to identify factors influencing overall survival GvHD development HLA-identical sibling alloHSCT. We have analyzed patients' donors' age, AB0 compatibility,...
Although most of the pertinent data on sequence-directed processes leading to genome rearrangements (GRs) have come from studies somatic tissues, little is known about GRs in germ line patients with hereditary disorders. This study aims at identifying DNA motifs and higher order structures architecture, which can result losses gains genetic material line. We first identified candidate by studying 112 pathogenic germ-line colorectal cancer patients, subsequently created an algorithm, termed...