A5002719979- Colorectal Cancer Treatments and Studies
- Cancer Genomics and Diagnostics
- Genetic factors in colorectal cancer
- Economic and Financial Impacts of Cancer
- Hematopoietic Stem Cell Transplantation
- Global Cancer Incidence and Screening
- Health Systems, Economic Evaluations, Quality of Life
- Colorectal Cancer Screening and Detection
- Chronic Lymphocytic Leukemia Research
- Cancer, Lipids, and Metabolism
- Bioinformatics and Genomic Networks
- Radiomics and Machine Learning in Medical Imaging
- Cancer Immunotherapy and Biomarkers
- Chronic Myeloid Leukemia Treatments
- Gene expression and cancer classification
- Advances in Oncology and Radiotherapy
- COVID-19 and healthcare impacts
- Histone Deacetylase Inhibitors Research
- Cancer, Hypoxia, and Metabolism
- Palliative Care and End-of-Life Issues
- RNA modifications and cancer
- Cancer Research and Treatments
- Lung Cancer Treatments and Mutations
- Acute Myeloid Leukemia Research
- Colorectal Cancer Surgical Treatments
Queen's University Belfast
2016-2025
European CanCer Organisation
2018-2025
Health Data Research UK
2018-2025
Benchmark (United Kingdom)
2024-2025
University of Leeds
2013-2025
eHealth Africa
2024
Institute of Molecular Medicine
2011-2023
National University of Ireland
2023
Cancer Research UK
2022
Queens University
2022
Genomic sequencing is rapidly transitioning into clinical practice, and implementation healthcare systems has been supported by substantial government investment, totaling over US$4 billion, in at least 14 countries. These national genomic-medicine initiatives are driving transformative change under real-life conditions while simultaneously addressing barriers to gathering evidence for wider adoption. We review the diversity of approaches current progress made UK, France, Australia, US...
Objectives To estimate the impact of COVID-19 pandemic on cancer care services and overall (direct indirect) excess deaths in people with cancer. Methods We employed near real-time weekly data to determine adverse effect services. also used these data, together national death registrations until June 2020 model deaths, background (pre-COVID-19) mortality, Background mortality risks for 24 cancers without COVID-19-relevant comorbidities were obtained from population-based primary cohort...
Background: Cancer and multiple non-cancer conditions are considered by the Centers for Disease Control Prevention (CDC) as high risk in COVID-19 emergency. Professional societies have recommended changes cancer service provision to minimize risks patients health care workers. However, we do not know extent which patients, whom multi-morbidity is common, may be at higher overall of mortality a net result factors including infection, services, socioeconomic factors. Methods: We report...
Abstract Molecular stratification using gene-level transcriptional data has identified subtypes with distinctive genotypic and phenotypic traits, as exemplified by the consensus molecular (CMS) in colorectal cancer (CRC). Here, rather than data, we make use of gene ontology biological activation state information for initial class discovery. In doing so, defined three pathway-derived (PDS) CRC: PDS1 tumors, which are canonical/LGR5 + stem-rich, highly proliferative display good prognosis;...
Financial toxicity, defined as both the objective financial burden and subjective distress from a cancer diagnosis its treatment, is topic of interest in assessment quality life patients with their families. Current evidence implicates toxicity psychosocial, economic other harms, leading to suboptimal outcomes along entire trajectory diagnosis, supportive care, survivorship palliation. This paper presents results virtual consensus, based on base date, screening management beyond organized by...
Activated protein C (APC) protects against sepsis in animal models and inhibits the lipopolysacharide (LPS)-induced elaboration of proinflammatory cytokines from monocytes. The molecular mechanism responsible for this property is unknown. We assessed effect APC on LPS-induced tumour necrosis factor alpha (TNF-alpha) production activation central transcription nuclear factor-kappaB (NF-kappaB) a THP-1 cell line. Cells were preincubated with varying concentrations (200 microg/ml, 100 microg/ml...
Abstract Purpose: A number of independent gene expression profiling studies have identified transcriptional subtypes in colorectal cancer with potential diagnostic utility, culminating publication a Consensus Molecular Subtype classification. The worst prognostic subtype has been defined by genes associated stem-like biology. Recently, it shown that the majority this poor group are stromal derived. We investigated for tumor misclassification into multiple subgroups based on tumoral region...
There are currently no approved targeted therapies for advanced KRAS mutant (KRASMT) colorectal cancer (CRC).Using a unique systems biology approach, we identified JAK1/2-dependent activation of STAT3 as the key mediator resistance to MEK inhibitors in KRASMT CRC vitro and vivo.Further analyses acute increases c-MET activity following treatment with models, which was demonstrated promote JAK1/ 2-STAT3-mediated resistance.Furthermore, inhibition found be due ERK-dependent metalloprotease...
Abstract Stromal-derived intratumoural heterogeneity (ITH) has been shown to undermine molecular stratification of patients into appropriate prognostic/predictive subgroups. Here, using several clinically relevant colorectal cancer (CRC) gene expression signatures, we assessed the susceptibility these signatures confounding effects ITH microarray data obtained from multiple tumour regions a cohort 24 patients, including central tumour, invasive front and lymph node metastasis. Sample...
To evaluate the impact of faecal immunochemical testing (FIT) prioritisation to mitigate delays in colorectal cancer (CRC) urgent diagnostic (2-week-wait (2WW)) pathway consequent from COVID-19 pandemic.
Abstract Right-sided (proximal) colorectal cancer (CRC) has a poor prognosis and distinct mutational profile, characterized by oncogenic BRAF mutations aberrations in mismatch repair TGFβ signalling. Here, we describe mouse model of right-sided colon driven loss epithelial TGFβ-receptor The proximal colonic tumours that develop this exhibit foetal-like progenitor phenotype ( Ly6a/Sca1 + ) and, importantly, lack expression Lgr5 its associated intestinal stem cell signature. These features are...