Rebecca C. Fitzgerald
A5050348689- Esophageal Cancer Research and Treatment
- Gastric Cancer Management and Outcomes
- Helicobacter pylori-related gastroenterology studies
- Esophageal and GI Pathology
- Cancer Genomics and Diagnostics
- Gastrointestinal Tumor Research and Treatment
- Eosinophilic Esophagitis
- Genetic factors in colorectal cancer
- Cancer-related gene regulation
- Gastroesophageal reflux and treatments
- Facial Rejuvenation and Surgery Techniques
- Lung Cancer Treatments and Mutations
- Pancreatic and Hepatic Oncology Research
- RNA modifications and cancer
- Lung Cancer Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Dermatologic Treatments and Research
- Gastrointestinal disorders and treatments
- Genomic variations and chromosomal abnormalities
- Radiomics and Machine Learning in Medical Imaging
- Cancer-related molecular mechanisms research
- Metastasis and carcinoma case studies
- Molecular Biology Techniques and Applications
- Botulinum Toxin and Related Neurological Disorders
- Cancer Immunotherapy and Biomarkers
University of Cambridge
2016-2025
Cancer Research UK Cambridge Center
2020-2025
Cancer Institute (WIA)
2023-2025
Hutchison/MRC Research Centre
2015-2024
MRC Cancer Unit
2015-2024
University of California, Los Angeles
2008-2024
Guy's Hospital
2024
Queen Mary University of London
2001-2024
Boston Children's Hospital
2024
Guy's and St Thomas' NHS Foundation Trust
2024
These guidelines provide a practical and evidence-based resource for the management of patients with Barrett9s oesophagus related early neoplasia. The Appraisal Guidelines Research Evaluation (AGREE II) instrument was followed to methodological strategy guideline development. A systematic review literature performed English language articles published up until December 2012 in order address controversial issues including definition, screening diagnosis, surveillance, pathological grading...
The mutational burden of aging As people age, they accumulate somatic mutations in healthy cells. About 25% cells normal, sun-exposed skin harbor cancer driver mutations. What about tissues not exposed to powerful mutagens like ultraviolet light? Martincorena et al. performed targeted gene sequencing normal esophageal epithelium from nine human donors varying age (see the Perspective by Chanock). mutation rate was lower esophagus than skin, but there a strong positive selection clones...
25–30% of families fulfilling the criteria for hereditary diffuse gastric cancer have germline mutations <i>CDH1</i> (E-cadherin) gene. In light new data and advancement technologies, a multidisciplinary workshop was convened to discuss genetic testing, surgery, endoscopy pathology reporting. The updated recommendations include broadening testing such that: histological confirmation is only required one family member; inclusion individuals with before age 40 years without history; diagnoses...
The Human Cell Atlas is a large international collaborative effort to map all cell types of the human body. Single-cell RNA sequencing can generate high-quality data for delivery such an atlas. However, delays between fresh sample collection and processing may lead poor difficulties in experimental design.This study assesses effect cold storage on healthy spleen, esophagus, lung from ≥ 5 donors over 72 h. We collect 240,000 single-cell transcriptomes with detailed type annotations whole...
Abstract About half of all cancers have somatic integrations retrotransposons. Here, to characterize their role in oncogenesis, we analyzed the patterns and mechanisms retrotransposition 2,954 cancer genomes from 38 histological subtypes within framework Pan-Cancer Analysis Whole Genomes (PCAWG) project. We identified 19,166 somatically acquired events, which affected 35% samples spanned a range event types. Long interspersed nuclear element (LINE-1; L1 hereafter) insertions emerged as first...
<b>Objectives</b> To determine the accuracy and acceptability to patients of non-endoscopic screening for Barrett’s oesophagus, using an ingestible oesophageal sampling device (Cytosponge) coupled with immunocytochemisty trefoil factor 3. <b>Design</b> Prospective cohort study. <b>Setting</b> 12 UK general practices, gastroscopies carried out in one hospital endoscopy unit. <b>Participants</b> 504 2696 eligible (18.7%) aged 50 70 years a previous prescription acid suppressant (H<sub>2</sub>...
Selenium, a trace element that is fundamental to human health, incorporated into some proteins as selenocysteine (Sec), generating family of selenoproteins. Sec incorporation mediated by multiprotein complex includes insertion sequence-binding protein 2 (SECISBP2; also known SBP2). Here, we describe subjects with compound heterozygous defects in the SECISBP2 gene. These individuals have reduced synthesis most 25 selenoproteins, resulting phenotype. Azoospermia, failure latter stages...
Background Barrett's esophagus (BE) is a commonly undiagnosed condition that predisposes to esophageal adenocarcinoma. Routine endoscopic screening for BE not recommended because of the burden this would impose on health care system. The objective study was determine whether novel approach using minimally invasive cell sampling device, Cytosponge, coupled with immunohistochemical staining biomarker Trefoil Factor 3 (TFF3), could be used identify patients who warrant endoscopy diagnose BE....
Abstract Esophageal adenocarcinoma (EAC) incidence is increasing while 5-year survival rates remain less than 15%. A lack of experimental models has hampered progress. We have generated clinically annotated EAC organoid cultures that recapitulate the morphology, genomic, and transcriptomic landscape primary tumor including point mutations, copy number alterations, mutational signatures. Karyotyping confirmed polyclonality reflecting clonal architecture tumor. Furthermore, subclones underwent...
Oesophageal adenocarcinoma is the sixth most common cause of cancer death worldwide and Barrett's oesophagus biggest risk factor. We aimed to evaluate efficacy high-dose esomeprazole proton-pump inhibitor (PPI) aspirin for improving outcomes in patients with oesophagus.
Treatment of dysplastic Barrett's oesophagus prevents progression to adenocarcinoma; however, the optimal diagnostic strategy for is unclear. The Cytosponge-trefoil factor 3 (TFF3) a non-endoscopic test oesophagus. aim this study was investigate whether offering patients on medication gastro-oesophageal reflux would increase detection compared with standard management.
A major challenge in cancer treatment is predicting clinical response to anti-cancer drugs on a personalized basis. Using pharmacogenomics database of 1,001 cell lines, we trained deep neural networks for prediction drug and assessed their performance multiple cohorts. We demonstrate that outperform the current state machine learning frameworks. provide proof concept use network-based frameworks aid precision oncology strategies.