Shaun R. Preston
A5046466273- Esophageal Cancer Research and Treatment
- Gastric Cancer Management and Outcomes
- Cancer Genomics and Diagnostics
- Esophageal and GI Pathology
- Gastrointestinal Tumor Research and Treatment
- Lung Cancer Treatments and Mutations
- Genetic factors in colorectal cancer
- Lung Cancer Diagnosis and Treatment
- Gallbladder and Bile Duct Disorders
- Helicobacter pylori-related gastroenterology studies
- RNA modifications and cancer
- Cardiac, Anesthesia and Surgical Outcomes
- COVID-19 and healthcare impacts
- Metastasis and carcinoma case studies
- Neuroendocrine Tumor Research Advances
- Bioinformatics and Genomic Networks
- Enhanced Recovery After Surgery
- Nutrition and Health in Aging
- Head and Neck Cancer Studies
- Neuropeptides and Animal Physiology
- Evolution and Genetic Dynamics
- Genomics and Chromatin Dynamics
- Pancreatic and Hepatic Oncology Research
- Surgical Simulation and Training
- Genomics and Phylogenetic Studies
Royal Surrey County Hospital
2016-2025
Royal Surrey NHS Foundation Trust
2021-2024
University of Manchester
2017-2023
Ludwig Cancer Research
2023
University of Oxford
2023
Oxford University Hospitals NHS Trust
2023
Laboratoire des Sciences de l'Ingénieur, de l'Informatique et de l'Imagerie
2020-2022
University of Birmingham
2020-2021
NIHR Birmingham Biomedical Research Centre
2021
Yorkshire Cancer Research
2021
4004 Background: The optimum combination curative approach to locally advanced adenocarcinoma of the esophagus and esophago-gastric junction (AEG) is unknown. A key question whether neoadjuvant multimodal therapy, specifically CROSS (carboplatin/paclitaxel, 41.4Gy radiation therapy), superior peri-operative chemotherapeutic regimens including modified MAGIC (epirubicin, cisplatin (oxaliplatin), 5-FU (capecitabine)) more latterly FLOT (docetaxel, 5-FU, leucovorin, oxaliplatin). Neo-AEGIS was...
The optimum curative approach to adenocarcinoma of the oesophagus and oesophagogastric junction is unknown. We aimed compare trimodality therapy (preoperative radiotherapy with carboplatin plus paclitaxel [CROSS regimen]) contemporaneous perioperative chemotherapy regimens (epirubicin cisplatin or oxaliplatin fluorouracil capecitabine [a modified MAGIC regimen] before 2018 fluorouracil, leucovorin, oxaliplatin, docetaxel [FLOT] subsequently).
Abstract CDKN2A is a tumor suppressor located in chromosome 9p21 and frequently lost Barrett’s esophagus (BE) esophageal adenocarcinoma (EAC). How other gene co-deletions affect EAC evolution remains understudied. We explored the effects of loss EACs cancer progressor non-progressor BEs with matched genomic, transcriptomic clinical data. Despite its driver role, BE prevents initiation by counterselecting subsequent TP53 alterations. predict poor patient survival but not through...
Neoadjuvant therapy is increasingly the standard of care in management locally advanced adenocarcinoma oesophagus and junction (AEG). In randomised controlled trials (RCTs), MAGIC regimen pre- postoperative chemotherapy, CROSS preoperative chemotherapy combined with radiation, were superior to surgery only RCTs that included AEG but not powered on this cohort. No completed RCT has directly compared neoadjuvant or perioperative chemoradiation. The Neo-AEGIS trial, uniquely AEG, including...
Abstract Background Oesophagogastric cancer surgery is immunosuppressive. This may be modulated by omega-3 fatty acids (O-3FAs). The aim of this study was to assess the effect perioperative O-3FAs on clinical outcome and immune function after oesophagogastric surgery. Methods Patients undergoing subtotal oesophagectomy total gastrectomy were recruited allocated randomly an O-3FA enteral immunoenhancing diet (IED) or standard nutrition (SEN) for 7 days before surgery, postoperative...
Abstract Background This multicentre cohort study sought to define a robust pathological indicator of clinically meaningful response neoadjuvant chemotherapy in oesophageal adenocarcinoma. Methods A questionnaire was distributed 11 UK upper gastrointestinal cancer centres determine the use assessment chemotherapy. Records consecutive patients undergoing oesophagogastric resection at seven between January 2000 and December 2013 were reviewed. Pathological assessed using Mandard Tumour...
Abstract Background Defined clinical pathways can contribute to improved outcomes in patients undergoing oesophageal cancer surgery. A standardized oesophagectomy pathway (SOCP) established at the Virginia Mason Medical Center (VMMC) Seattle, Washington, USA was introduced into Royal Surrey County Hospital (RSCH), Guildford, UK 2011. The aim of this study see whether transfer and implementation an care could change postoperative significantly. Methods Three consecutively accrued groups were...
295 Background: The optimum combination curative approach to locally advanced adenocarcinoma of the esophagus and esophago-gastric junction (AEG) remains controversial, specifically whether multimodal therapy or perioperative chemotherapy is superior. Neo-AEGIS was designed as first randomized clinical trial (RCT) directly compare CROSS regimen (carboplatin/paclitaxel, 41.4Gy radiation therapy) with a modified MAGIC (epirubicin, cisplatin (oxaliplatin), 5-FU (capecitabine)) (pre-2018) more...
The following, from the 12th OESO World Conference: Cancers of Esophagus, includes commentaries on role nurse in preparation esophageal resection (ER); management patients who develop high-grade dysplasia after having undergone Nissen fundoplication; trajectory care for patient with cancer; influence site tumor choice treatment; best location esophagogastrostomy; chylous leak esophagectomy; optimal approach to manage thoracic operational surgery cardioesophageal crossing; advantages robot...
Abstract Background Early cancer recurrence after oesophagectomy is a common problem, with an incidence of 20–30 per cent despite the widespread use neoadjuvant treatment. Quantification this risk difficult and existing models perform poorly. This study aimed to develop predictive model for early surgery oesophageal adenocarcinoma using large multinational cohort machine learning approaches. Methods Consecutive patients who underwent had treatment in one Dutch six UK oesophagogastric units...
Abstract Esophageal adenocarcinoma is a prominent example of cancer characterized by frequent amplifications in oncogenes. However, the mechanisms leading to amplicons that involve breakage-fusion-bridge cycles and extrachromosomal DNA are poorly understood. Here, we use 710 esophageal cases with matched samples patient-derived organoids disentangle complex their associated mechanisms. Short-read sequencing identifies ERBB2 , MYC MDM2, HMGA2 as most oncogenes amplified DNAs. We resolve...
Abstract Background Long-term symptom burden and health-related quality-of-life outcomes after curative oesophageal cancer treatment are poorly understood. Existing tools cumbersome do not address the post-treatment population specifically. The aim of this study was to validate six-symptom LASORS tool for identifying patients with poor quality life assess its clinical utility. Methods Between 2015 2019, from 15 UK centres who underwent curative-intent treatment, were disease-free at least 1...
Weight loss following esophagectomy is a management challenge for all patients. It multifactorial with contributing factors including of gastric reservoir, rapid small bowel transit, malabsorption, and adjuvant chemotherapy. The development postoperative malabsorption syndrome, as result exocrine pancreatic insufficiency (EPI), recognized in subgroup patients gastrectomy. This has not previously been documented esophageal resection. EPI can symptoms flatulence, diarrhea, steatorrhea, vitamin...
Background Cognitive deficits in schizophrenia have major functional impacts. Modafinil is a cognitive enhancer whose effect healthy volunteers well-described, but effects on the of appear to be inconsistent. Two possible reasons for this are that test batteries vary their sensitivity, or phase illness may important, with patients early responding better. Methods A double-blind, randomised, placebo-controlled single-dose crossover study modafinil 200 mg examined two [MATRICS Consensus...
The identification of cancer-promoting genetic alterations is challenging particularly in highly unstable and heterogeneous cancers, such as esophageal adenocarcinoma (EAC). Here we describe a machine learning algorithm to identify cancer genes individual patients considering all types damaging simultaneously. Analysing 261 EACs from the OCCAMS Consortium, discover helper that, alongside well-known drivers, promote cancer. We confirm robustness our approach 107 additional EACs. Unlike...
In this retrospective pilot study we examine the feasibility of establishing a confidential enquiry into why some patients die after emergency admission to hospital. After excluding those who died in first hour or were admitted for palliative care, pairs physicians able collect quantitative and qualitative data on 200 consecutive deaths. Both reported shortfalls care 14 one pair 25 whose deaths would not have been expected outcome. 25, may contributed their Major problems delays seeing...