A5079148939- Esophageal Cancer Research and Treatment
- Gastric Cancer Management and Outcomes
- Esophageal and GI Pathology
- Lung Cancer Diagnosis and Treatment
- Gastrointestinal Tumor Research and Treatment
- Metastasis and carcinoma case studies
- Radiomics and Machine Learning in Medical Imaging
- Surgical Simulation and Training
- Gastroesophageal reflux and treatments
- Medical Imaging Techniques and Applications
- Nutrition and Health in Aging
- Cardiac, Anesthesia and Surgical Outcomes
- Minimally Invasive Surgical Techniques
- Anatomy and Medical Technology
- Dysphagia Assessment and Management
- Tracheal and airway disorders
- Colorectal Cancer Surgical Treatments
- Enhanced Recovery After Surgery
- Multiple and Secondary Primary Cancers
- Gastrointestinal disorders and treatments
- MRI in cancer diagnosis
- Congenital Diaphragmatic Hernia Studies
- Advanced Radiotherapy Techniques
- Colorectal Cancer Screening and Detection
- Cancer Immunotherapy and Biomarkers
University Medical Center Utrecht
2016-2025
Utrecht University
2016-2025
Heidelberg University
2014-2025
University Hospital Heidelberg
2014-2025
Collaborative Group (United States)
2024
Ninewells Hospital
2023
St Mary's Hospital
2023
St. Mary's Hospital
2023
Imperial College London
2023
International Breast Cancer Study Group
2021
The standard curative treatment for patients with esophageal cancer is perioperative chemotherapy or preoperative chemoradiotherapy followed by open transthoracic esophagectomy (OTE). Robot-assisted minimally invasive thoracolaparoscopic (RAMIE) may reduce complications.A single-center randomized controlled trial was conducted, assigning 112 resectable intrathoracic to either RAMIE OTE. primary endpoint the occurrence of overall surgery-related postoperative complications (modified...
The aim of this study was to evaluate the worldwide trends in surgical techniques for esophageal cancer surgery by comparing it our survey from 2007. In addition, new questions were added gastroesophageal junction (GEJ) cancer. An international on and GEJ performed among members International Society Diseases Esophagus, World Organization Specialized Studies Disease Gastric Cancer Association. Also, surgeons personal networks contacted. participants filled out a web based questionnaire about...
The CROSS trial established neoadjuvant chemoradiotherapy (nCRT) for patients with resectable esophageal adenocarcinoma (rEAC). In the PERFECT trial, we investigated feasibility and efficacy of nCRT combined programmed-death ligand-1 (PD-L1) inhibition rEAC.Patients rEAC received according to regimen five cycles atezolizumab (1,200 mg). primary endpoint was administering in ≥75% patients. A propensity score-matched cohort used compare pathologic response, overall survival, progression-free...
The oncological efficacy and safety of laparoscopic gastrectomy are under debate for the Western population with predominantly advanced gastric cancer undergoing multimodality treatment.In 10 experienced upper GI centers in Netherlands, patients resectable (cT1-4aN0-3bM0) adenocarcinoma were randomly assigned to either or open gastrectomy. No masking was performed. primary outcome hospital stay. Analyses performed by intention treat. It hypothesized that leads shorter stay, less...
The OligoMetastatic Esophagogastric Cancer (OMEC) project aims to provide clinical practice guidelines for the definition, diagnosis, and treatment of esophagogastric oligometastatic disease (OMD).
Robot-assisted surgical systems have been introduced to improve the outcome of minimally invasive surgery. These also potential ergonomics for surgeon during endoscopic This study aimed compare user’s mental and physical comfort in performing standard laparoscopic robot-assisted techniques. Surgical performance was analyzed. In this study, 16 surgically inexperienced participants performed three tasks using both a robotic system instrumentation. Distress measured questionnaires an ambulatory...
For esophageal cancer patients, radical esophagolymphadenectomy is the cornerstone of multimodality treatment with curative intent. Transthoracic esophagectomy preferred surgical approach worldwide allowing for en-bloc resection tumor surrounding lymph nodes. However, percentage cardiopulmonary complications associated transthoracic high (50 to 70%). Recent studies have shown that robot-assisted minimally invasive thoraco-laparoscopic (RATE) at least equivalent open in terms short-term...
Open transthoracic esophagectomy is the worldwide gold standard in treatment of resectable esophageal cancer. Robot-assisted minimally invasive thoraco-laparoscopic (RAMIE) for cancer may be associated with reduced blood loss, shorter intensive care unit (ICU) stay, and less cardiopulmonary morbidity; however, long-term oncologic results have not been reported to date.Between June 2007 September 2011, a total 108 patients potentially underwent RAMIE at University Medical Centre Utrecht,...
Abstract Background Studies comparing the anastomotic leak rate in patients with an intrathoracic versus a cervical anastomosis after oesophagectomy are equivocal. The aim of this study was to compare clinical outcome or anastomosis, and identify predictors leakage nationwide audit. Methods Between January 2011 December 2015, all consecutive who underwent for cancer were identified from Dutch Upper Gastrointestinal Cancer Audit. For comparison between propensity score matching used adjust...
Abstract Background Vital signs are usually recorded once every 8 h in patients at the hospital ward. Early of deterioration may therefore be missed. Wireless sensors have been developed that capture patient earlier. The objective this study was to determine whether two wearable patch (SensiumVitals [Sensium Healthcare Ltd., United Kingdom] and HealthPatch [VitalConnect, USA]), a bed-based system (EarlySense [EarlySense Israel]), patient-worn monitor (Masimo Radius-7 [Masimo Corporation,...
For gastric cancer patients, surgical resection with en-bloc lymphadenectomy is the cornerstone of curative treatment. Open gastrectomy has long been preferred approach worldwide. However, this procedure associated considerable morbidity. Several meta-analyses have shown an advantage in short-term outcomes laparoscopic compared to open procedures, similar oncologic outcomes. it remains unclear whether results these Asian studies can be extrapolated Western population. In trial from...
SUMMARY Robot-assisted minimally invasive esophagectomy (RAMIE) is increasingly being applied as treatment for esophageal cancer. In this study, the results of 50 RAMIE procedures were compared with conventional (MIE) operations, which had been standard cancer prior to robotic era. Between April 2016 and March 2018, data 100 consecutive patients carcinoma undergoing modified Ivor Lewis prospectively collected. All operations performed by same surgeon using an identical intrathoracic...
Morbidity and mortality after esophagectomy are often related to anastomotic leakage or pneumonia. This study aimed assess the relationship of intraoperative postoperative vital parameters with pneumonia esophagectomy. Consecutive patients who underwent transthoracic cervical anastomosis for esophageal cancer from January 2012 December 2013 were analyzed. Univariable multivariable logistic regression analyses used determine potential associations hemodynamic respiratory From a total 82...
Abstract Background Up to 40 per cent of patients undergoing oesophagectomy develop pneumonia. The aim this study was assess whether preoperative inspiratory muscle training (IMT) reduces the rate pneumonia after oesophagectomy. Methods Patients with oesophageal cancer were randomized a home-based IMT programme before surgery or usual care. included use flow-resistive loading device, and instructed train twice day at high intensity (more than 60 maximum strength) for 2 weeks longer until...
Abstract Background To allocate healthcare resources optimally, complication-related quality initiatives should target complications that have the greatest overall impact on outcomes after surgery. The aim of this study was to identify most clinically relevant oesophagectomy for cancer in a nationwide cohort study. Methods Consecutive patients who underwent between January 2011 and December 2016 were identified from Dutch Upper Gastrointestinal Cancer Audit. adjusted population attributable...