A5003899958- Organ Transplantation Techniques and Outcomes
- Hepatocellular Carcinoma Treatment and Prognosis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Liver Disease and Transplantation
- Liver Disease Diagnosis and Treatment
- Gallbladder and Bile Duct Disorders
- Renal Transplantation Outcomes and Treatments
- Hepatitis C virus research
- Pancreatic and Hepatic Oncology Research
- Liver Diseases and Immunity
- Viral-associated cancers and disorders
- Transplantation: Methods and Outcomes
- Drug Transport and Resistance Mechanisms
- Oral and gingival health research
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Neuroendocrine Tumor Research Advances
- Pediatric Hepatobiliary Diseases and Treatments
- Polyomavirus and related diseases
- Esophageal and GI Pathology
- Hepatitis B Virus Studies
- MicroRNA in disease regulation
- Colorectal Cancer Treatments and Studies
- Amino Acid Enzymes and Metabolism
- Neurological Complications and Syndromes
- Cancer Mechanisms and Therapy
Johannes Gutenberg University Mainz
2015-2024
University Medical Center of the Johannes Gutenberg University Mainz
2015-2024
Klinik und Poliklinik für Psychosomatische Medizin und Psychotherapie
2012-2024
Erasmus MC Transplant Institute
2021
Erasmus MC Cancer Institute
2021
Osaka University
2020
Cleveland Clinic Lerner College of Medicine
2019
Goethe University Frankfurt
2019
University Medical Center
2018
Marienhaus Klinikum Hetzelstift Neustadt
2015
Criteria to select patients with hepatocellular carcinoma (HCC) for liver transplantation (LT) are based on tumor size and number of nodules rather than biology. The present study was undertaken assess the role transarterial chemoembolization (TACE) in selecting tumors suitable LT. Ninety-six consecutive HCC were treated by repeatedly performed TACE, 62 them exceeding Milan criteria. Patients meeting criteria immediately listed, beyond listing listed upon downstaging following successful...
Aiming at avoidance of futile surgery, we have tested whether radiofrequency ablation (RFA) may be used as first-line treatment in patients with colorectal metastases (CRLM) occurring within the first year after surgery.Surgical resection is standard CRLM. Major retrospective analyses identified interval between surgery and occurrence CRLM to prognostic importance. So far, it unknown survival respective hampered if RFA treatment.According a clinical pathway, treated detected preferentially...
SUMMARY Robot-assisted minimally invasive esophagectomy (RAMIE) is increasingly being applied as treatment for esophageal cancer. In this study, the results of 50 RAMIE procedures were compared with conventional (MIE) operations, which had been standard cancer prior to robotic era. Between April 2016 and March 2018, data 100 consecutive patients carcinoma undergoing modified Ivor Lewis prospectively collected. All operations performed by same surgeon using an identical intrathoracic...
The debate about the best approach to select patients with hepatocellular cancer (HCC) waiting for liver transplantation (LT) is still ongoing. This study aims identify variables allowing discriminate between "high-" and "low-benefit" patients. To do so, concept of intention-to-treat (ITT) survival benefit LT has been created. Data 2,103 adult HCC consecutively enlisted during period 1987-2015 were analyzed. Three rigorous statistical steps used in order create ITT LT: development an a...
Abstract Background Organic cation transporters (OCT) are responsible for the uptake and intracellular inactivation of a broad spectrum endogenous substrates detoxification xenobiotics chemotherapeutics. The became pharmaceutically interesting, because OCTs determinants cytotoxicity platin derivates transport activity has been shown to correlate with sensitivity tumors towards tyrosine kinase inhibitors. No data exist about relevance in hepatocellular carcinoma (HCC). Methods OCT1 ( SLC22A1...
The aim of this study was to analyze clinical presentation, course disease, and management patients with hepatocellular carcinoma (HCC) in a German referral center between 1998 2009.HCC is rare tumor Germany, but its incidence has increased over the last 30 years. New therapies such as chemoembolization drug-eluting beads, selective internal radiotherapy, sorafenib were introduced recently; however, impact on overall survival (OS) unclear.In retrospective analysis, 1066 HCC, separated into...
Accurate preoperative prediction of hepatocellular carcinoma (HCC) recurrence after liver transplant is the mainstay selection tools used by transplant-governing bodies to discern candidacy for patients with HCC. Although progress has been made, few incorporate objective measures tumor biological characteristics, resulting in inclusion high rates and exclusion others who could otherwise be cured.To externally validate New York/California (NYCA) score, a recently published multi-institutional...
Living-donor liver transplant (LDLT) offers advantages over deceased-donor (DDLT) of improved intention-to-treat outcomes and management the shortage allografts. However, conflicting data still exist on LDLT in patients with hepatocellular carcinoma (HCC).To investigate potential survival benefit an HCC from time waiting list inscription.This multicenter cohort study design analyzed aged 18 years or older who had diagnosis were a for first transplant. Patients 12 collaborative centers...
HCC recurrence following liver transplantation (LT) is highly morbid and occurs despite strict patient selection criteria. Individualized prediction of post-LT risk remains an important need. Clinico-radiologic pathologic data 4981 patients with undergoing LT from the US Multicenter Transplant Consortium (UMHTC) were analyzed to develop a REcurrent Liver cAncer Prediction ScorE (RELAPSE). Multivariable Fine Gray competing analysis machine learning algorithms (Random Survival Forest...
Liver transplantation (LT) is the only curative option for patients with familial amyloid polyneuropathy (FAP) at present. Twenty FAP underwent LT between May 1998 and June 2007. Transthyretin mutations included predominantly Val30Met mutation but also 10 other mutations. Seven received a pacemaker prior to LT, because of impairment mechanical cardiac function, 4 combined heart-liver transplants were performed, 1 simultaneously 3 sequentially. The first patient, who simultaneous...
Prognosticating outcomes in liver transplant (LT) for hepatocellular carcinoma (HCC) continues to challenge the field. Although Milan Criteria (MC) generalized practice of LT HCC and improved outcomes, its predictive character has degraded with increasing candidate oncological heterogeneity. We sought validate recalibrate a previously developed, preoperatively calculated, continuous risk score, Hazard Associated Liver Transplantation Hepatocellular Carcinoma (HALTHCC), an international...
Cholangiocellular carcinoma (CCA) is a primary hepatic malignancy derived from cholangiocytes. The prognosis for CCA patients very poor and conventional chemotherapy has been proven ineffective in improving long‑term patient survival rates. Organic cation transporters (OCTs) mediate the transport of broad spectrum endogenous substrates detoxification xenobiotics. Moreover, OCTs are considered responsible responsiveness towards platinum‑based chemotherapies. Currently, there no data available...
The polyspecific organ cation transporter 1 (OCT1) is one of the most important active influx pumps for drugs like kinase inhibitor sorafenib. aim this retrospective study was definition role intratumoral OCT1 mRNA expression in hepatocellular carcinoma (HCC) as a biomarker systemic treatment with levels were determined biopsies from 60 primary human HCC by real time PCR. data retrospectively correlated clinical parameters. Intratumoral significant positive prognostic factor patients treated...
Primary hepatic angiosarcoma (PHA) is a rare tumor entity. Radical surgical resection currently considered the best treatment choice. The aim of this analysis to report our experience with surgery for PHA.All resections PHA from 01/2002 until 06/2017 were identified prospective institutional database. All cases re-confirmed by second pathologist. We analyzed completeness resection, overall (OS) and disease-free survival (DFS).Nine patients underwent resection. Median follow-up after was 15.5...
In patients with hepatocellular carcinoma (HCC) meeting the Milan criteria (MC), benefit of locoregional therapies (LRTs) in context liver transplantation (LT) is still debated. Initial biases selection between treated and untreated have yielded conflicting reported results. The study aimed to identify, using a competing risk analysis, factors for HCC‐dependent LT failure, defined as pretransplant tumor‐related delisting or posttransplant recurrence. was registered at www.clinicaltrials.gov...
The aim of this prospective, randomized, double-blinded, placebo-controlled single center study was to evaluate an early steroid-free immunosuppression in liver transplant patients.From March 2000 October 2004, 110 patients were included. All received tacrolimus and steroids during the first 2 weeks after orthotopic transplantation (OLT). Thereafter, steroid group (n=54) remaining 56 a placebo. After 6 months, for all free. Thirty hepatitis C positive. Five years inclusion, patient survival,...
<i>Background/Aims:</i> The use of intraoperative blood salvage autotransfusion (IBSA) during surgical approaches may contribute to tumour cell dissemination. Therefore, IBSA should be avoided in cases malignancy. However, the risks might acceptable liver transplantation (LT) for selected small hepatocellular carcinoma (HCC). <i>Methods:</i> In total, 136 recipients LT with histologically proven HCC explanted were included this analysis. With regard recurrence, 40...