A5074054302- Organ Transplantation Techniques and Outcomes
- Liver Disease and Transplantation
- Liver Disease Diagnosis and Treatment
- Renal Transplantation Outcomes and Treatments
- Hepatitis C virus research
- Hepatitis B Virus Studies
- Transplantation: Methods and Outcomes
- Liver Diseases and Immunity
- Liver physiology and pathology
- Neurological Complications and Syndromes
- COVID-19 Clinical Research Studies
- Cytomegalovirus and herpesvirus research
- Long-Term Effects of COVID-19
- Pneumocystis jirovecii pneumonia detection and treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Herpesvirus Infections and Treatments
- HIV/AIDS drug development and treatment
- Metabolism and Genetic Disorders
- Antifungal resistance and susceptibility
- Clostridium difficile and Clostridium perfringens research
- Clinical Nutrition and Gastroenterology
- SARS-CoV-2 and COVID-19 Research
- Drug-Induced Hepatotoxicity and Protection
- Immune Response and Inflammation
- Pediatric Hepatobiliary Diseases and Treatments
Hospital Universitario Puerta de Hierro Majadahonda
2015-2024
Universidad Autónoma de Madrid
2014-2024
Centro de Investigación Biomédica en Red
2023
Centro de Investigación en Red en Enfermedades Cardiovasculares
2023
Weatherford College
2021
Hospital Universitario La Paz
2019
Universidad Internacional De La Rioja
2019
National Cancer Registry
2016
Centre for Biomedical Network Research on Rare Diseases
2008
Organización Nacional de Trasplantes
2002
Twenty-seven clinical and laboratory data the subsequent course of 93 consecutive adult patients who underwent orthotopic liver transplantation for various chronic advanced diseases were analyzed retrospectively to assess risk factors early major bacterial infection death after procedure. Forty-one (44%) had during hospitalization transplantation. The mortality rate was 70.7% in with 7.7% without (p < 0.001). Total serum bilirubin, total white blood cell count polymorphonuclear count, IgG...
Novel coronavirus disease 2019 (COVID-19) emerged in Wuhan and rapidly spread, affecting >10 million cases worldwide. Caused by severe acute respiratory syndrome 2 (SARS-CoV-2) primarily manifesting as an failure with interstitial alveolar pneumonia, it can also affect multiple organs. Kidney involvement was underestimated early reports its role remains controversial. The aim of this study to analyse the kidney damage COVID-19 outcome.
A prospective, randomized, multicenter study addressed the safety and efficacy of fluconazole therapy in 143 liver transplant patients. Seventy-six patients received daily oral (100 mg), 67 nystatin (4 × 106 U) during first 28 days after transplantation. Candida colonization occurred 25% 53% groups, respectively (P = .04), 13% 34% respective groups had infections .022). Of these patients, 10.5% group 25.3% superficial candidal .024). Invasive candidiasis developed 2 (2.6%) 6 (9.0%) .12)....
Recurrence of autoimmune hepatitis after liver transplantation is not rare, but there little information about its time onset, risk factors, response to treatment and prognosis. The aim this study was evaluate the rate recurrence outcome transplantation.The records patients transplanted in eight centers our country between 1984 1996 were retrospectively analyzed.Forty-three 2331 (1.8%) recipients fulfilled diagnostic criteria at transplantation. Sixteen excluded from evaluation. Nine (33%)...
One hundred twenty-nine adult patients who received an orthotopic liver transplantation and survived at least 24 hr after surgery were evaluated. During the period of follow-up, 48 129 (37%) died. Only 40 these died our institution included in this study. Seventeen deaths (42.5%) occurred during first month 30 (75%) 60 days post-orthotopic transplantation. Death was related to infection 21 cases (52.5%), multiorgan failure 8 (20%) uncontrollable rejection 3 (7.6%). The remaining eight...
Hepatitis C recurrence after liver transplantation (LT) is universal, and frequently leads to cirrhosis death. The aim of our study was assess the efficacy safety 48-weeks full-dose peg-interferon-alpha-2a (n = 4) or alpha-2b 51) plus ribavirin (>11 mg/kg/day) in a multicentric cohort 55 patients > =12 months LT. All subjects had histologically proven HCV recurrence, excluding severe cholestatic recurrence. Mean age 54.3 +/- 9.7, 77% male, 90.9% genotype 1, 32.7% cirrhotics. but 5 received...
Surgical site infections are common bacterial in orthotopic liver transplantation. The purpose of this study was to determine the incidence, timing, location, and risk factors, specifically antibiotic prophylaxis, for surgical infections. A prospective performed that included a population 1222 consecutive patients (73.0% males) who underwent transplantation Spanish hospitals belonging Red de Estudio la Infección en el Trasplante research network. One hundred seven developed predominant...
Treatment with direct-acting antivirals (DAA) eradicates hepatitis C virus (HCV) from most chronic carriers. Information on regression of liver fibrosis and the influence HIV is scarce in cured patients.All consecutive HCV-infected individuals treated DAA at our institution were examined. Hepatic elastography was performed baseline time SVR12. Liver defined as a shift advanced (Metavir F3-F4) to null-mild (F0-F2) and/or reduction greater than 30% kPa. AST platelet ratio index (APRI) 4...
Bacterial infections may complicate the course of COVID-19 patients. The rate and predictors bacterial were examined in patients consecutively admitted with at one tertiary hospital Madrid between March 1st April 30th, 2020. Among 1594 hospitalized COVID-19, 135 (8.5%) experienced infectious events, distributed as follows: urinary tract (32.6%), bacteremia (31.9%), pneumonia (31.8%), intra-abdominal (6.7%) skin soft tissue (6.7%). Independent older age, neurological disease, prior...
Mortality and re-admission rates for decompensated acute heart failure (AHF) is increasing overall risk stratification might be challenging. We sought to evaluate the prognostic role of systemic venous ultrasonography in patients hospitalized AHF. prospectively recruited 74 AHF with a NT-proBNP level above 500 pg/mL. Then, multi-organ ultrasound assessments (lung, inferior vena cava (IVC), pulsed-wave Doppler (PW-Doppler) hepatic, portal, intra-renal femoral veins) were performed at...
Orthotopic liver retransplantation (re-OLT) is highly controversial. The objectives of this study were to determine the validity a recently developed United Network for Organ Sharing (UNOS) multivariate model using an independent cohort patients undergoing re-OLT outside States, whether incorporation other variables that incomplete in UNOS registry would provide additional prognostic information, develop new models combining data sets from both cohorts, and evaluate end-stage disease (MELD)...
The LIS2T study was an open-label, multicenter in which recipients of a primary liver transplant were randomized to cyclosporine microemulsion (CsA-ME) (Neoral) (n = 250) (monitoring blood concentration at 2 hours postdose) C2 or tacrolimus 245) trough drug level [predose]) C0 compare efficacy and safety 3 6 months evaluate patient status 12 months. All patients received steroids with without azathioprine. At months, 85% CsA-ME 86% survived functioning graft (P not significant). Efficacy...
Background. Cytomegalovirus (CMV) infection causes morbidity in solid organ transplant (SOT) recipients, either by direct injury or association with chronic allograft rejection other opportunistic infections. Ganciclovir is the treatment of choice, but this agent requires intravenous administration, which affects its feasibility for long‐term use. Valganciclovir, has an oral bioavailability 60%, proven to be useful prophylaxis CMV high‐risk SOT recipients and treating retinitis persons...
Transmission of infection from donor to recipient is a potential complication transplantation. More data on this issue are needed expand the insufficient pool. This study evaluates incidence nonviral infection, transmission infected donors and effect 30-day survival. Data 211 contributing 292 (8.8%) 3322 consecutive transplant procedures within RESITRA (Spanish Research Network for Study Infection in Transplantation) were prospectively compiled analyzed. Lung was most likely transplanted...
Cardiovascular (CV) diseases are recognized longterm causes of death after liver transplantation (LT). The objective this multicenter study was to analyze the prevalence and evolution CV risk factors morbidity mortality in 1819 LT recipients along 5 years LT. influence baseline variables on survival, morbidity, studied. There a continuous significant increase all (except smoking) were fourth cause LT, causing 12% deaths during follow-up. Most events (39%) occurred first year Preexisting such...