A5016307813- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Cytomegalovirus and herpesvirus research
- Renal Transplantation Outcomes and Treatments
- Antifungal resistance and susceptibility
- Organ Transplantation Techniques and Outcomes
- Hepatitis C virus research
- COVID-19 and healthcare impacts
- Herpesvirus Infections and Treatments
- SARS-CoV-2 and COVID-19 Research
- Pneumocystis jirovecii pneumonia detection and treatment
- Liver Disease and Transplantation
- Transplantation: Methods and Outcomes
- Liver Disease Diagnosis and Treatment
- Fungal Infections and Studies
- Respiratory Support and Mechanisms
- Neurological Complications and Syndromes
- Influenza Virus Research Studies
- Neutropenia and Cancer Infections
- Sepsis Diagnosis and Treatment
- Antibiotics Pharmacokinetics and Efficacy
- Hepatitis B Virus Studies
- COVID-19 and Mental Health
- Respiratory viral infections research
- Intensive Care Unit Cognitive Disorders
Hospital Universitario 12 De Octubre
2015-2025
Universidad Complutense de Madrid
2015-2025
Research Institute Hospital 12 de Octubre
2014-2025
Instituto de Salud Carlos III
2017-2025
Centro de Investigación Biomédica en Red
2015-2025
Johns Hopkins University
2024
Johns Hopkins Medicine
2024
Hospital Costa del Sol
2023
Centro de Investigación Biomédica en Red de Cáncer
2022
Vall d'Hebron Hospital Universitari
2020
The clinical characteristics, management, and outcome of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome 2 (SARS-CoV-2) after solid organ transplant (SOT) remain unknown. We report our preliminary experience with 18 SOT (kidney [44.4%], liver [33.3%], heart [22.2%]) recipients diagnosed COVID-19 March 23, 2020 at a tertiary-care center Madrid. Median age diagnosis was 71.0 ± 12.8 years, the median interval since transplantation 9.3 years. Fever (83.3%)...
To facilitate the design of strategies for prevention invasive aspergillosis in solid-organ transplant recipients, this study investigates whether development early-onset and late-onset are related to different risk factors, thereby distinguishing 2 populations serious complication.A retrospective case-control was performed, including 156 cases proven or probable patients recruited from 11 Spanish centers since start centers' transplantation programs.Among all patients, 57% had IA (i.e.,...
Previous studies have suggested a more frequent and severe course of novel coronavirus SARS-CoV-2 infection in cancer patients undergoing active oncologic treatment. Our aim was to describe the characteristics disease this population determine predictive factors for poor outcome terms respiratory distress (acute syndrome [ARDS]) or death.
To describe the characteristics and prognosis of patients with COPD admitted to hospital due SARS-CoV-2 infection.
Granulocyte colony-stimulating factors (G-CSFs) have been shown to help prevent febrile neutropenia in certain subgroups of cancer patients undergoing chemotherapy, but their role treating is controversial. The purpose our study was evaluate-in a prospective multicenter randomized clinical trial-the efficacy adding G-CSF broad-spectrum antibiotic treatment with solid tumors and high-risk neutropenia.A total 210 treated conventional-dose chemotherapy who presented fever grade IV were...
A prospective, randomized, multicenter study addressed the safety and efficacy of fluconazole therapy in 143 liver transplant patients. Seventy-six patients received daily oral (100 mg), 67 nystatin (4 × 106 U) during first 28 days after transplantation. Candida colonization occurred 25% 53% groups, respectively (P = .04), 13% 34% respective groups had infections .022). Of these patients, 10.5% group 25.3% superficial candidal .024). Invasive candidiasis developed 2 (2.6%) 6 (9.0%) .12)....
Cardiovascular infections due to Salmonella enterica are infrequently reported, so their clinical features, prognosis, and optimal treatment not completely known. Mortality associated with aortitis endocarditis caused by nontyphoidal remains exceedingly high. In this review of cases cardiovascular studied in 2 hospitals Madrid, we tried assess the manifestations procedures leading diagnosis addition outcome. To complete spectrum related surgery, postoperative mediastinitis, pericarditis,...
We evaluated the clinical significance of unrecognized bacteremia in organ donor (i.e., blood culture results that were reported to be positive after transplantation) on outcome transplant recipients. Twenty-nine 569 liver and heart donors (5%) had at time procurement, but there no documented instances transmission isolated bacteria from recipient. Unrecognized does not have a negative impact
Background. Current advances in transplantation practices may influence the development of cytomegalovirus (CMV) disease after renal transplantation. Methods. From September 2003 through February 2005, 1470 transplant recipients (55 whom were kidney-pancreas recipients) prospectively studied 16 centers affiliated with Spanish Network Infection Transplantation, use an ad hoc–designed online database. Univariate and multivariate analyses logistic regression performed to detect risk factors for...
Information describing the incidence and clinical char-acteristics of late infection (LI) in solid organ transplan-tation (SOT) is scarce. The aim this study was to define incidence, characteristics risk factors for LI (>6 months) as compared with early period (<6 after SOT. By on-line database Spanish Network Infection Transplantation (RESITRA) we prospectively analyzed 2702 SOT recipients from September 2003 February 2005. Univariate multivariate analysis using logis-tic regression were...
BackgroundInformation regarding the incidence and characteristics of COVID-19 pneumonia amongst pregnant women is scarce.MethodsSingle-centre experience with 32 diagnosed between March 5 to April 5, 2020 at Madrid, Spain.FindingsCOVID-19 was in 61·5% (32/52) women. Only 18·7% (6/32) had some underlying condition (mostly asthma). Supplemental oxygen therapy required 18 patients (56·3%), high-flow requirements six (18·7%). Eight (25·0%) fulfilled criteria for acute distress respiratory...
Abstract Coronavirus disease 2019 (COVID‐19) can lead to a massive cytokine release. The use of the anti‐interleukin‐6 receptor monoclonal antibody tocilizumab (TCZ) has been proposed in this hyperinflammatory phase, although supporting evidence is limited. We retrospectively analyzed 88 consecutive patients with COVID‐19 pneumonia that received at least one dose intravenous TCZ our institution between 16 and 27 March 2020. Clinical status from day 0 (first dose) through 14 was assessed by...
The timing of the development specific adaptive immunity after natural SARS-CoV-2 infection, and its relevance in clinical outcome, has not been characterized depth. Description long-term maintenance both cellular humoral responses elicited by real-world anti-SARS-CoV-2 vaccination is still scarce. Here we aimed to understand optimal protective infection vaccination. We performed an early, longitudinal study S1-, M- N-specific IFN-γ IL-2 T cell anti-S total neutralizing antibodies 88 mild,...
The aim of our study was to elucidate if SARS-CoV-2 viral load on admission, measured by real-time reverse transcriptase–polymerase chain reaction (rRT-PCR) cycle threshold (Ct) value nasopharyngeal samples, a marker disease severity. All hospitalized adult patients with diagnosis infection rRT-PCR performed nasopharingeal sample from March 1 18 in institution were included. population divided according the Ct obtained upon admission high (Ct < 25), intermediate (Ct: 25–30) and low > 30)....