A5035633220- Liver Disease and Transplantation
- Liver Disease Diagnosis and Treatment
- Organ Transplantation Techniques and Outcomes
- Liver Diseases and Immunity
- COVID-19 Clinical Research Studies
- Pancreatic and Hepatic Oncology Research
- Renal Transplantation Outcomes and Treatments
- Hepatitis C virus research
- Pancreatitis Pathology and Treatment
- Long-Term Effects of COVID-19
- Hepatitis B Virus Studies
- Child Nutrition and Feeding Issues
- Clinical Nutrition and Gastroenterology
- Neuroendocrine Tumor Research Advances
- Pneumocystis jirovecii pneumonia detection and treatment
- Diagnosis and treatment of tuberculosis
- SARS-CoV-2 and COVID-19 Research
- Hepatitis Viruses Studies and Epidemiology
- Diverticular Disease and Complications
- Abdominal Surgery and Complications
- Appendicitis Diagnosis and Management
- Antibiotics Pharmacokinetics and Efficacy
- Birth, Development, and Health
- Esophageal and GI Pathology
- Ocular Diseases and Behçet’s Syndrome
Hospital General Universitario Gregorio Marañón
2013-2024
Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas
2017-2024
Universidad Complutense de Madrid
2020-2024
Instituto de Salud Carlos III
2024
Centro de Investigación Biomédica en Red
2022
Centro de Investigación Biomédica en Red de Salud Mental
2017
Universidad San Pablo CEU
2017
Abstract Background and Aims Small series suggest that rituximab could be effective as treatment for autoimmune hepatitis (AIH), although data are scarce. We aimed to evaluate the efficacy safety of in different cohorts patients with AIH. Methods Multicentre retrospective analysis 35 AIH its variant forms treated included ColHai registry between 2015 2023. Results Most were female (83%), 10 (29%) had cirrhosis four (11.4%) Indication follows: 14(40%) refractory AIH, 19(54%) concomitant or...
Objective Explore the impact of COVID-19 on patients waiting list for liver transplantation (LT) and their post-LT course. Design Data from consecutive adult LT candidates with were collected across Europe in a dedicated registry analysed. Results From 21 February to 20 November 2020, 136 cases laboratory-confirmed SARS-CoV-2 infection 33 centres 11 European countries collected, 113 having COVID-19. Thirty-seven (37/113, 32.7%) died after median 18 (10–30) days, respiratory failure being...
Summary Background and Aims To assess whether corticosteroids improve prognosis in patients with AS‐AIH, to identify factors at therapy initiation during predictive of the response corticosteroids. Methods This was a retrospective cohort study including all AS‐AIH admitted 13 tertiary centres from January 2002 2019. The composite primary outcome death or liver transplantation within 90 days admission. Kaplan–Meier Cox regression methods were used for data analysis. Results Of 242 consecutive...
HIV-positive patients on tenofovir hydroxyl fumarate (TDF)/emtricitabine have a lower risk of COVID-19 and hospitalization than those given other treatments. Our aim was to analyze the severity in with chronic hepatitis B (CHB) TDF or entecavir (ETV). Spanish hospital databases (n = 28) including information regarding adult CHB ETV for period February 1st November 30th 2020 were searched COVID-19, defined as positive SARS-CoV-2 polymerase chain reaction, severe COVID-19. Of 4736 patients,...
The value of noninvasive tools in the diagnosis autoimmune hepatitis (AIH)–related cirrhosis and prediction clinical outcomes is largely unknown. We sought to evaluate (1) utility liver stiffness measurement (LSM) (2) performance Sixth Baveno Consensus on Portal Hypertension (Baveno VI), expanded VI, ANTICIPATE models predicting absence varices needing treatment (VNT). A multicenter cohort 132 patients with AIH‐related was retrospectively analyzed. LSM endoscopies performed at time were...
The prevalence and management of coronary artery disease (CAD) in liver transplantation (LT) candidates are not well characterized. aims this study were to evaluate the impact on clinical outcomes a specifically designed protocol for asymptomatic CAD LT investigate noninvasive risk profiles obstructive nonobstructive 202 candidates. Those with high baseline cardiovascular (CVR; defined by presence classic CVR factors and/or decreased ejection fraction) received angiography significant...
Hepatic encephalopathy (HE) remains a diagnosis of exclusion due to the lack specific signs and symptoms.Refractory HE is an uncommon but serious condition that requires search hidden precipitating events (i.e. , portosystemic shunt) alternative CASE
Long-term humoral immunity and its protective role in liver transplantation (LT) patients have not been elucidated. We performed a prospective multicenter study to assess the persistence of immunoglobulin G (IgG) antibodies LT recipients 12 months after coronavirus disease 2019 (COVID-19). A total 65 were matched with nontransplanted by propensity score including variables recognized impact on COVID-19. showed lower prevalence anti-nucleocapsid (27.7% versus 49.2%; P = 0.02) anti-spike IgG...
Background. A comprehensive mechanistic assessment of normothermic machine perfusion (NMP) is an essential step toward identifying biomarkers to assess liver viability. Although some studies have evaluated the effect NMP on inflammation markers, there are other key pathological mechanisms involved in ischemia/reperfusion injury (IRI) that not yet been evaluated. Methods. Eight human donor livers preserved by were included analyze IRI during preservation. Concentrations several different...
Background. Demographic analyses may reveal current patterns of change in the outcomes rapidly developing medical procedures because they incorporate period perspective. Methods. We analyzed changes size, age structure, and hospitalizations population liver transplantation (LT) survivors our center during last 30 y (n = 1114 patients) generated projections, including life expectancy (LE), considering cohort effects. Life tables were used to project complete LE (overall 1990–2020 experience),...
Abstract Background and Aims Metabolic dysfunction‐associated steatotic liver disease (MASLD) recurrence after transplantation (LT) seems unavoidable gradual. We aimed to evaluate the diagnostic accuracy in post‐LT setting of patients transplanted for metabolic steatohepatitis (MASH) recurrent hepatic steatosis fibrosis identified with FibroScan, compared biopsy findings. Methods This prospective cohort study included adults MASH between 2010 2022 three LT centres Spain who underwent...
Introduction: the presence of donor-specific antibodies (DSA) is thought to affect survival allograft and patient after liver transplantation (LT). However, their significance not well understood. Patients methods: a prospective study was performed 32 adult patients who underwent LT in 2011 analyze existence DSA, associated risk factors medium-term impact. Immunological determinations were immediately before at three, six, 12 months five years LT. Results: eight (24.2 %) presented pre-formed...
infections by multidrug-resistant bacteria are a major cause of morbidity and mortality in transplant patients.a retrospective single-center study was performed to evaluate the implementation an Antimicrobial Treatment Optimization Program (PROA) on colonization infection after liver (LT).colonization during first year were analyzed group 76 transplanted patients two stages, before PROA (2016-2019). Clinical variables related infection, readmissions survival one analyzed.there good adherence...