A5070081707- Liver Disease Diagnosis and Treatment
- Hepatitis C virus research
- Hepatitis B Virus Studies
- Liver Diseases and Immunity
- Liver Disease and Transplantation
- HIV/AIDS drug development and treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Hepatitis Viruses Studies and Epidemiology
- Renal Transplantation Outcomes and Treatments
- Gallbladder and Bile Duct Disorders
- Organ Transplantation Techniques and Outcomes
- Pediatric Hepatobiliary Diseases and Treatments
- COVID-19 Clinical Research Studies
- Pancreatic and Hepatic Oncology Research
- Pancreatitis Pathology and Treatment
- Pneumocystis jirovecii pneumonia detection and treatment
- Diabetes and associated disorders
- Pharmacological Effects and Toxicity Studies
- Diet, Metabolism, and Disease
- Chronic Disease Management Strategies
- Cannabis and Cannabinoid Research
- Renal cell carcinoma treatment
- Rheumatoid Arthritis Research and Therapies
- Advanced Glycation End Products research
- Lymphoma Diagnosis and Treatment
Hospital Del Mar
2013-2024
Hospital del Mar Research Institute
2013-2023
Parc de Salut
2011-2023
Universitat Autònoma de Barcelona
2008-2022
Municipal Institute for Medical Research
2008-2022
Instituto de Salud Carlos III
2018
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2003-2015
University of Naples Federico II
2013
Hospital Clínic de Barcelona
2003-2012
Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas
2012
The study of hepatitis C virus (HCV) kinetics after liver transplantation (LT) might be important to design strategies prevent HCV infection the graft. We analyzed during and immediately LT in 20 consecutive patients undergoing for HCV-related cirrhosis. RNA was quantified blood samples obtained at regular intervals before, during, transplantation. HCV-RNA concentrations decreased 18 anhepatic phase (mean decay slope −0.92, mean elimination half-life 2.2 hours). found a significant...
Preliminary reports suggested that hepatitis C virus (HCV) infection has a more aggressive course following living donor liver transplantation (LDLT) compared to cadaveric (CLT). The aim of this prospective study was establish if HCV disease recurrence differs between LDLT and CLT. A cohort 116 consecutive HCV-infected patients undergoing 117 LTs in single center from March 2000 August 2003 were followed-up, including systematic biopsies. Severe (SR) defined as biopsy-proven cirrhosis and/or...
Background Hepatitis B virus (HBV) reactivation in patients with resolved HBV infection (HBsAg negative, antiHBc positive) is uncommon, but potentially fatal. The role of prophylaxis this setting uncertain. aim study was to compare the efficacy tenofovir disoproxil fumarate (TDF) versus close monitoring antiHBc-positive, HBsAg-negative under treatment rituximab (RTX)-based regimens for hematologic malignancy. Methods PREBLIN a phase IV, randomized, prospective, open-label, multicenter,...
Abstract Microwave (MWA) and radiofrequency ablation (RFA) are main ablative techniques for hepatocellular carcinoma (HCC) colorectal liver metastasis (MT). This randomized phase 2 clinical trial compares the effectiveness of MWA RFA as well morphology corresponding zones. HCC MT patients with 1.5–4 cm tumors, suitable ablation, were into or Groups. The primary endpoint was short-to-long diameter ratio zone (SLR). Primary technical success (TS) a cumulative local tumor progression (LTP)...
Background and Aims: In patients with non-severe acute or chronic autoimmune hepatitis (AIH) without cirrhosis, clinical practice guidelines recommend indistinct use of prednisone budesonide. However, budesonide is infrequently used in practice. We aimed to describe its compare efficacy safety as first-line options. Approach Results: This was a retrospective, multicenter study 105 naive AIH treated the drug. The control group included 276 prednisone. Efficacy assessed using logistic...
Abstract Background & Aims Alcoholic hepatitis (AH) is associated with a high incidence of infection and mortality. Rifaximin reduces bacterial overgrowth translocation. We aimed to study whether the administration rifaximin as an adjuvant treatment corticosteroids decreases number infections at 90 days in patients severe AH compared control cohort. Methods This was multicentre, open, comparative pilot addition (1200 mg/day/90 days) standard for AH. The results were carefully matched...
The landscape in primary biliary cholangitis (PBC) has changed with the advent of second-line treatments. However, use obeticholic acid (OCA) and fibrates PBC-related cirrhosis is challenging. We assessed impact receiving a therapy as risk factor for decompensated real-world population PBC, identify predictive factors these patients.
Abstract Background The development of liver cirrhosis is usually an asymptomatic process until late stages when complications occur. potential reversibility the disease dependent on early diagnosis fibrosis and timely targeted treatment. Recently, use non-invasive tools has been suggested for screening fibrosis, especially in subjects with risk factors chronic disease. Nevertheless, large population-based studies cost-effectiveness analyses are still lacking to support widespread such...
Background and Aims: The prognostic weight of further decompensation in cirrhosis is still unclear. We investigated the incidence its effect on mortality patients with cirrhosis. Approach Results: Multicenter cohort study. cumulative (development a second event or complication decompensating event) was assessed using competing risks analysis 2028 patients. A 4-state model built: first decompensation, liver transplant, death. cause-specific Cox used to assess adjusted mortality. Sensitivity...
Hepatitis C recurrence after liver transplantation is often associated with accelerated graft fibrosis and progression to cirrhosis. Because drugs blocking the action of angiotensin-II can reduce in different human experimental models, we assessed possible beneficial effect these on hepatitis transplantation.We retrospectively reviewed charts 128 liver-transplant recipients recurrence. Twenty-seven patients (group I) received angiotensin converting enzyme inhibitors or receptor antagonists...
Despite its medical and legal implications, there are no prospective studies analyzing the incidence mechanisms involved in nosocomial transmission of hepatitis C virus (HCV) liver units. This study prospectively investigates HCV unit a tertiary care center from August 2000 to October 2002. The median prevalence infection among hospitalized patients was 50%. Anti-HCV–negative admitted during period were followed, serum markers repeated 6 months after discharge. All known risk factors for...
Abstract Background and Aim Transient elastography is the reference method for liver stiffness measurement (LSM) in general population, having lower applicability obese patients. We evaluated diagnostic accuracy of M XL probes overweight/obese patients to establish most appropriate approach. Methods From May 2013 March 2015, we with a body mass index (BMI) ≥ 28 kg/m 2 . constructed an algorithm variables independently related unreliable LSM probe. Results A total 1084 were evaluated. probe...
HIV-positive patients on tenofovir hydroxyl fumarate (TDF)/emtricitabine have a lower risk of COVID-19 and hospitalization than those given other treatments. Our aim was to analyze the severity in with chronic hepatitis B (CHB) TDF or entecavir (ETV). Spanish hospital databases (n = 28) including information regarding adult CHB ETV for period February 1st November 30th 2020 were searched COVID-19, defined as positive SARS-CoV-2 polymerase chain reaction, severe COVID-19. Of 4736 patients,...
Primary care has a crucial role to play in the prevention, early detection, referral, and risk factor management of non-alcoholic fatty liver disease steatohepatitis (NAFLD/NASH). In 2021, team European collaborators developed continuing medical education (CME) program on NAFLD/NASH that consolidates evidence clinical best practices tailored primary setting. This article reports methodology used design develop CME results feasibility study.An expert advisory group representing both...
Liver cirrhosis caused by chronic hepatitis C virus (HCV) infection is the main indication for liver transplantation (LT). There little information on HCV genetic evolution following transplantation. The aim of this study was to carefully assess early quasispecies in a cohort 18 transplant recipients followed prospectively. Quasispecies analysis performed sequence hypervariable region 1 (HVR1) before and at day 4 week LT. A predominant variant present 12 (67%) patients same propagated...
Summary Transient elastography ( TE ) is the reference method to obtain liver stiffness measurements LSM ), but no results are obtained in 3.1% and unreliable 15.8%. We assessed applicability diagnostic accuracy of re‐evaluation using M XL probes. From arch 2011 A pril 2012 868 were performed with probe by trained operators (50–500 studies) 1). Measurements categorized as inadequate (no values or ratio <60% and/or IQR / >30%) adequate. Inadequate 1 re‐evaluated experienced (>500...