A5101821895- Liver Disease Diagnosis and Treatment
- Alcohol Consumption and Health Effects
- Liver Disease and Transplantation
- Diet, Metabolism, and Disease
- Hepatitis C virus research
- Substance Abuse Treatment and Outcomes
- Endoplasmic Reticulum Stress and Disease
- Liver physiology and pathology
- Gut microbiota and health
- Eicosanoids and Hypertension Pharmacology
- Diet and metabolism studies
- Hepatitis B Virus Studies
- Pancreatitis Pathology and Treatment
- Drug-Induced Hepatotoxicity and Protection
- Liver Diseases and Immunity
- Bone and Dental Protein Studies
- Mitochondrial Function and Pathology
- Fibroblast Growth Factor Research
- Pancreatic function and diabetes
- Lipid metabolism and disorders
- Global Public Health Policies and Epidemiology
- Peroxisome Proliferator-Activated Receptors
- Biomarkers in Disease Mechanisms
- Metabolomics and Mass Spectrometry Studies
- Abdominal Trauma and Injuries
Universitat Autònoma de Barcelona
2009-2024
Vall d'Hebron Institut de Recerca
2009-2023
Hospital Quirónsalud Barcelona
2018-2022
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2011-2021
University of Basilicata
2021
University of Ljubljana
2021
Pukyong National University
2021
Russian Academy of Sciences
2021
Multidisciplinary Digital Publishing Institute (Switzerland)
2021
University of California, San Diego
2019
Alcoholic hepatitis (AH) frequently progresses to multiple organ failure (MOF) and death. However, the driving factors are largely unknown. At admission, patients with AH often show criteria of systemic inflammatory response syndrome (SIRS) even in absence an infection. We hypothesize that presence SIRS may predispose MOF To test this hypothesis, we studied a cohort including 162 biopsy‐proven AH. The infections was assessed all patients, multivariate analyses identified variables...
Chronic alcohol consumption causes increased intestinal permeability and changes in the microbiota composition, which contribute to development progression of alcohol-related liver disease. In this setting, little is known about commensal fungi gut. We studied mycobiota a cohort patients with alcoholic hepatitis, use disorder, nonalcoholic controls using fungal-specific internal transcribed spacer amplicon sequencing fecal samples. further measured serum anti-Saccharomyces cerevisiae...
Abstract Alcoholic hepatitis (AH) is a life-threatening condition characterized by profound hepatocellular dysfunction for which targeted treatments are urgently needed. Identification of molecular drivers hampered the lack suitable animal models. By performing RNA sequencing in livers from patients with different phenotypes alcohol-related liver disease (ALD), we show that development AH defective activity liver-enriched transcription factors (LETFs). TGF β 1 key upstream transcriptome...
Alcoholic hepatitis (AH) is a severe condition developed in patients with underlying alcoholic liver disease. Ductular reaction has been associated chronic alcohol consumption but there no information regarding the extent of progenitor cell (LPC) proliferation AH. The aim this study was to investigate LPC markers AH and its correlation disease severity. Fifty-nine clinical histological diagnosis were included study. assessed by real-time polymerase chain (PCR) immunohistochemistry. Standard...
<h3>Objective</h3> Alcoholic hepatitis (AH) is a severe clinical condition that needs novel therapies. The identification of targets for therapy hampered by the lack animal models advanced AH. authors performed translational study through transcriptome analysis in patients with AH to identify new molecular targets. <h3>Design</h3> Hepatic gene expression profiling was assessed DNA microarray (n=15) and normal livers (n=7). Functional set enrichment analysis. Quantitative PCR (n=40), C...
*Clinical Professor of Surgery, University Guadalajara; Head Department Plastic Dermatological Institute, Public Health Service, Guadalajara. †Fellow Surgery Department,
Alcoholic hepatitis (AH) is the most severe form of alcoholic liver disease. Most studies have focused on short‐term prognosis, whereas factors associated with long‐term survival are largely unknown. The aims our study were to (1) determine impact complete abstinence from alcohol and (2) identify prognostic at admission capable predicting during follow‐up in patients AH. One hundred forty‐two biopsy‐proven AH that survived first episode included. Demographic, psychiatric, biochemical...
OBJECTIVES: After an acute variceal bleeding, early decision for aggressive management of patients with worse prognosis may improve outcomes. The effectiveness currently recommended standard therapy (drugs plus endoscopic ligation) different risk subgroups and the validity available criteria in clinical practice are unknown. METHODS: We analyzed data 301 consecutive cirrhotic admitted esophageal bleeding. All received antibiotics, somatostatin, 263 therapy. A stratified 6-week mortality...
Objective Chemokines are known to play an important role in the pathophysiology of alcoholic hepatitis (AH), a form acute-on-chronic liver injury frequently mediated by gut derived lipopolysaccharide (LPS). In our study, we hypothesise that chemokine CCL20, one most upregulated chemokines patients with AH, is implicated pathogenesis AH mediating LPS induced injury. Design CCL20 gene expression and serum levels their correlation disease severity were assessed AH. Cellular sources its...
Liver disease and portal hypertension can be associated with pulmonary vascular complications, including portopulmonary (POPH), characterised by an elevated mean artery pressure secondary to increased resistance, hepatopulmonary syndrome (HPS), hypoxaemia due vasodilatation shunting. Although clear diagnostic guidelines exist for both conditions on the basis of echocardiography, right heart catheterisation arterial blood gases, there is considerable variation between centres regarding...
<h3>Objective</h3> MicroRNAs (miRNAs) are well-known regulators of disease pathogenesis and have great potential as biomarkers therapeutic targets. We aimed at profiling miRNAs in alcoholic hepatitis (AH) identifying potentially involved liver injury. <h3>Design</h3> MiRNA was performed samples from patients with AH, alcohol disease, non-alcoholic steatohepatitis, HCV normal tissue. Expression assessed serum AH animal models. Mimic decoy miR-182 were used vitro vivo to evaluate miR-1829s...
Alcoholic hepatitis (AH) is a severe manifestation of alcohol-associated liver disease (ALD) with high mortality. Although gut bacteria and fungi modulate severity, little known about the effects viral microbiome (virome) in patients ALD.We extracted virus-like particles from 89 AH who were enrolled multicenter observational study, 36 alcohol use disorder (AUD), 17 persons without AUD (controls). Virus-like fecal samples fractionated using differential filtration techniques, metagenomic...
The diagnosis of alcoholic hepatitis (AH) often requires a transjugular liver biopsy (TJLB), procedure that is not always readily accessible. We analyzed plasma biomarkers to estimate the presence histological features AH among patients with clinical suspicion AH. Using enzyme‐linked immunosorbent assay, we tested M65 and M30 (circulating fragments cytokeratin‐18) their respective fraction carried by microvesicles (MVs), CCL20 TREM1. Leukocyte, platelet, endothelial‐derived MVs were...
Prednisolone therapy increases the risk of infections in patients with severe alcoholic hepatitis (SAH). We evaluated whether use Lille Model at day 4 (LM4) is useful to predict response prednisolone compared classic 7 (LM7) order limit a futile exposure corticosteroids.We performed retrospective analysis large multinational cohort SAH Maddrey's discriminant function (DF) ≥32. Response corticosteroids was assessed LM4 and LM7, according validated cutoff value (CUV>0.45). Receiver operating...
INTRODUCTION: Several scoring systems predict mortality in alcohol-associated hepatitis (AH), including the Maddrey discriminant function (mDF) and model for end-stage liver disease (MELD) score developed United States, Glasgow alcoholic Kingdom, age, bilirubin, international normalized ratio, creatinine Spain. To date, no global studies have examined utility of these scores, nor has MELD-sodium been evaluated outcome prediction AH. In this study, we assessed accuracy different scores to...