M. Arfan Ikram
A5036303967- Genetic Associations and Epidemiology
- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Cerebrovascular and Carotid Artery Diseases
- Epigenetics and DNA Methylation
- Cardiovascular Health and Disease Prevention
- Advanced Neuroimaging Techniques and Applications
- Acute Ischemic Stroke Management
- Diet and metabolism studies
- Nutritional Studies and Diet
- Intracerebral and Subarachnoid Hemorrhage Research
- Bioinformatics and Genomic Networks
- Blood Pressure and Hypertension Studies
- Neurological Disease Mechanisms and Treatments
- Metabolomics and Mass Spectrometry Studies
- Health, Environment, Cognitive Aging
- Functional Brain Connectivity Studies
- Folate and B Vitamins Research
- Liver Disease Diagnosis and Treatment
- Health disparities and outcomes
- Cancer-related molecular mechanisms research
- Genetics and Neurodevelopmental Disorders
- Health Systems, Economic Evaluations, Quality of Life
- Nutrition, Genetics, and Disease
- Advanced MRI Techniques and Applications
Erasmus MC
2016-2025
Erasmus University Rotterdam
2016-2025
International Medical University
2025
Tamil Nadu Agricultural University
2024-2025
Oasis Hospital
2025
Harvard University
2013-2024
Delft University of Technology
2011-2024
Lund University
2024
Lahore College for Women University
2024
University Medical Center
2024
Sequence variants, including the ε4 allele of apolipoprotein E, have been associated with risk common late-onset form Alzheimer's disease. Few rare variants affecting disease found.
Magnetic resonance imaging (MRI) of the brain is increasingly used both in research and clinical medicine, scanner hardware MRI sequences are continually being improved. These advances likely to result detection unexpected, asymptomatic abnormalities, such as tumors, aneurysms, subclinical vascular pathologic changes. We conducted a study determine prevalence incidental findings general population.The subjects were 2000 persons (mean age, 63.3 years; range, 45.7 96.7) from population-based...
Background Alzheimer's disease is a common debilitating dementia with known heritability, for which 20 late onset susceptibility loci have been identified, but more remain to be discovered. This study sought identify new genes, using an alternative gene-wide analytical approach tests patterns of association within in the powerful genome-wide dataset International Genomics Project Consortium, comprising over 7 m genotypes from 25,580 cases and 48,466 controls. Principal Findings In addition...
<b>Background: </b> Cerebral microbleeds are focal deposits of hemosiderin that can be visualized with MRI. Little is known on their prevalence in the general population and etiology. It has been suggested that, analogy to spontaneous intracranial hemorrhage, etiology differs according location brain, lobar being caused by cerebral amyloid angiopathy deep or infratentorial resulting from hypertension atherosclerosis. We investigated risk factors for aged 60 years older. <b>Methods: This...
We previously reported on the high prevalence of cerebral microbleeds (CMBs) in community-dwelling people aged 60 years and older. Moreover, we found that their spatial distribution likely reflects differences underlying etiology. have since almost quadrupled number participants our study expanded it to include persons 45 examined determinants this larger younger cohort from general population.In 3979 (mean age, 60.3 years), performed brain MRI at 1.5T, including a sequence optimized for...
Large genomic reference data sets reveal a spectrum of pathogenicity in the prion protein gene and provide genetic validation for therapeutic strategy disease.
The Rotterdam Study is a prospective cohort study ongoing since 1990 in the city of Netherlands. targets cardiovascular, endocrine, hepatic, neurological, ophthalmic, psychiatric, dermatological, otolaryngological, locomotor, and respiratory diseases. As 2008, 14,926 subjects aged 45 years or over comprise cohort. Since 2016, being expanded by persons 40 over. findings have been presented 1500 research articles reports (see www.erasmus-epidemiology.nl/rotterdamstudy ). This article gives...
Cerebral hypoperfusion has previously been associated with mild cognitive impairment and dementia in various cross-sectional studies, but whether precedes neurodegeneration is unknown. We prospectively determined the association of cerebral perfusion subsequent decline development dementia.Between 2005 2012, we measured blood flow by 2-dimensional phase-contrast magnetic resonance imaging participants population-based Rotterdam Study without dementia. (mL/100mL/min) risk (until 2015) using a...
The Rotterdam Study is an ongoing prospective cohort study that started in 1990 the city of Rotterdam, Netherlands. aims to unravel etiology, preclinical course, natural history and potential targets for intervention chronic diseases mid-life late-life. focuses on cardiovascular, endocrine, hepatic, neurological, ophthalmic, psychiatric, dermatological, otolaryngological, locomotor, respiratory diseases. As 2008, 14,926 subjects aged 45 years or over comprise cohort. Since 2016, being...