Renée de Mutsert
A5101505299- Genetic Associations and Epidemiology
- Liver Disease Diagnosis and Treatment
- Adipokines, Inflammation, and Metabolic Diseases
- Diet and metabolism studies
- Cardiovascular Disease and Adiposity
- Diet, Metabolism, and Disease
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Adipose Tissue and Metabolism
- Metabolomics and Mass Spectrometry Studies
- Obesity, Physical Activity, Diet
- Nutrition, Genetics, and Disease
- Birth, Development, and Health
- Regulation of Appetite and Obesity
- Dialysis and Renal Disease Management
- Cardiovascular Function and Risk Factors
- Sleep and related disorders
- Chronic Kidney Disease and Diabetes
- Nutrition and Health in Aging
- Epigenetics and DNA Methylation
- Physical Activity and Health
- Biochemical Analysis and Sensing Techniques
- RNA modifications and cancer
- Lipid metabolism and disorders
- Cardiovascular Health and Disease Prevention
- Bioinformatics and Genomic Networks
Leiden University Medical Center
2016-2025
Weatherford College
2024
Loyola University Medical Center
2023
The University of Texas Health Science Center at Houston
2020
Netherlands Metabolomics Centre
2020
Biobanking and BioMolecular resources Research Infrastructure The Netherlands
2020
Leiden University
2006-2019
Johns Hopkins University
2018
Lancaster University
2017
University College London
2017
Body fat distribution is, next to overall obesity, an important risk factor for cardiometabolic outcomes in the general population. In particular, visceral adipose tissue (VAT) is strongly associated with factors. Since it unclear whether body also men and women obesity we investigated associations between measures of factors obesity.In this cross-sectional analysis obese (BMI≥30 kg/m2) included Netherlands Epidemiology Obesity Study, waist:hip ratio(WHR), waist circumference, MRI-based...
Background: The implications of different adiposity measures on cardiovascular disease etiology remain unclear. In this article, we quantify and contrast causal associations central (waist-to-hip ratio adjusted for body mass index [WHRadjBMI]) general (body [BMI]) with cardiometabolic disease. Methods: Ninety-seven independent single-nucleotide polymorphisms BMI 49 WHRadjBMI were used to conduct Mendelian randomization analyses in 14 prospective studies supplemented coronary heart (CHD) data...
Increased levels of the urinary albumin-to-creatinine ratio (UACR) are associated with higher risk kidney disease progression and cardiovascular events, but underlying mechanisms incompletely understood. Here, we conduct trans-ethnic (n = 564,257) European-ancestry specific meta-analyses genome-wide association studies UACR, including ancestry- diabetes-specific analyses, identify 68 UACR-associated loci. Genetic correlation analyses score associations in an independent electronic medical...
Abstract Genome-wide association analyses using high-throughput metabolomics platforms have led to novel insights into the biology of human metabolism 1–7 . This detailed knowledge genetic determinants systemic has been pivotal for uncovering how pathways influence biological mechanisms and complex diseases 8–11 Here we present a genome-wide study 233 circulating metabolic traits quantified by nuclear magnetic resonance spectroscopy in up 136,016 participants from 33 cohorts. We identify...
Background. Protein-energy wasting (PEW), inflammation and cardiovascular diseases (CVD) clearly contribute to the high mortality in chronic dialysis. Our aim was examine presence of additive interaction between these three risk factors their association with long-term dialysis patients. Methods. Patients from a prospective multi-centre cohort study among ESRD patients starting first treatment [the Netherlands Co-operative Study on Adequacy Dialysis-2 (NECOSAD-II)] complete data were...
The relative importance of overweight after childhood and excess weight gain during adulthood remains unclear. In 39,909 male participants the Health Professionals Follow-Up Study who were 40-75 years age in 1986 followed until 2008, we documented 8,755 incident cases obesity-related chronic diseases (type 2 diabetes mellitus, cardiovascular diseases, colorectal, renal, pancreatic, esophageal cancers). We calculated composite cause-specific hazard ratios using a model that included body mass...
Elevated blood pressure is a major risk factor for cardiovascular disease and has substantial genetic contribution. Genetic variation influencing the potential to identify new pharmacological targets treatment of hypertension. To discover additional novel loci, we used 1000 Genomes Project–based imputation in 150 134 European ancestry individuals sought significant evidence independent replication further 228 245 individuals. We report 6 signals association or near HSPB7 , TNXB LRP12...
The prevalence of metabolic syndrome varies among populations with different ethnicities. Asian develop complications at lower amounts adiposity than western populations. role abdominal obesity in the differences between two is poorly understood.Our objectives were to estimate and relative contribution its components Indonesian Dutch population, as well examine associations overall syndrome.In this cross-sectional study middle-aged adults Netherlands Epidemiology Obesity Study (n = 6602)...
Many studies show that obesity in dialysis patients is not strongly associated with mortality but whether this modest association constant over age. This study investigated the extent to which relation of body mass index (BMI) and differs between younger older patients.Adult were prospectively followed from their first treatment for 7 years or until death transplantation. Patients stratified by age (<65 ≥65 years) baseline BMI (<20, 20-24 [reference], 25-29, ≥30 kg/m(2)).The sample included...
Hepatic steatosis is associated with poor cardiometabolic health, de novo lipogenesis (DNL) contributing to hepatic and subsequent insulin resistance. saturated fatty acids (SFA) may be a marker of DNL are suggested most detrimental in Here, we show cross-sectional study design (ClinicalTrials.gov ID: NCT03211299) that able distinguish the fractions SFA, mono- polyunsaturated healthy metabolically compromised volunteers using proton magnetic resonance spectroscopy (1H-MRS). positively SFA...
Recent genetic studies have identified alleles associated with opposite effects on adiposity and risk of type 2 diabetes. We aimed to identify more these variants test the hypothesis that such favorable are higher subcutaneous fat lower ectopic fat. combined MRI data genome-wide association body percentage (%) metabolic traits. report 14 alleles, including 7 newly characterized but a profile. Consistent previous studies, individuals carrying had % BMI diabetes, heart disease, hypertension....