A5073595027- Sleep and related disorders
- Circadian rhythm and melatonin
- Sleep and Wakefulness Research
- Cholinesterase and Neurodegenerative Diseases
- Computational Drug Discovery Methods
- Genetic Associations and Epidemiology
- Dietary Effects on Health
- Healthcare Regulation
- Impact of Light on Environment and Health
- Phosphodiesterase function and regulation
- Obesity, Physical Activity, Diet
- Health, Education, and Aging
- Neurobiology and Insect Physiology Research
- Youth, Drugs, and Violence
- Nicotinic Acetylcholine Receptors Study
- Breastfeeding Practices and Influences
- Eating Disorders and Behaviors
- Nuclear Structure and Function
- Psychology and Mental Health
- bioluminescence and chemiluminescence research
- Child Nutrition and Feeding Issues
- Sleep and Work-Related Fatigue
- Kruppel-like factors research
- Genetic Mapping and Diversity in Plants and Animals
- Folate and B Vitamins Research
Sanofi (Germany)
2017-2019
Ludwig-Maximilians-Universität München
2007-2017
Helmholtz Zentrum München
2010
Technical University of Darmstadt
2005-2006
Universidade Federal do Paraná
2002-2004
Abstract Being a morning person is behavioural indicator of person’s underlying circadian rhythm. Using genome-wide data from 697,828 UK Biobank and 23andMe participants we increase the number genetic loci associated with being 24 to 351. 85,760 individuals activity-monitor derived measures sleep timing find that chronotype associate timing: mean 5% carrying most morningness alleles 25 min earlier than fewest. The are enriched for genes involved in regulation, cAMP, glutamate insulin...
In public health, mood disorders are among the most important mental impairments. Patients with depressive episodes exhibit daily variations, abnormal patterns in sleep-wake behavior, and rhythms of several endocrine-metabolic parameters. Although relationship between sleep/circadian processes is poorly understood, clock-related therapies, such as light therapy, sleep deprivation, rigid schedules, have been shown to be effective treatments. Several studies investigated circadian phenotype...
Little is known about human entrainment under natural conditions, partly due to the complexity of behavior, torn between biological and social time influenced by zeitgebers (light–dark cycles) that are progressively “polluted” (and thereby weakened) artificial light. In addition, data seasonal variations in sleep parameters scarce. We, therefore, investigated variation cross-sectional assessments sleep/wake times 9765 subjects from four European populations (EGCUT = Estonian Genome Centre,...
Recent genetic studies have identified alleles associated with opposite effects on adiposity and risk of type 2 diabetes. We aimed to identify more these variants test the hypothesis that such favorable are higher subcutaneous fat lower ectopic fat. combined MRI data genome-wide association body percentage (%) metabolic traits. report 14 alleles, including 7 newly characterized but a profile. Consistent previous studies, individuals carrying had % BMI diabetes, heart disease, hypertension....
Glucagon-like peptide 1 (GLP-1) stimulated insulin secretion has a considerable heritable component as estimated from twin studies, yet few genetic variants influencing this phenotype have been identified. We performed the first genome-wide association study (GWAS) of GLP-1 in non-diabetic individuals Netherlands Twin register (n = 126). This GWAS was enhanced using tissue-specific protein-protein interaction network approach. identified beta-cell module that significantly enriched for low...
Morningness-eveningness dimension in humans have been indicated to influence social behavior and individual health. The aim of the present study was investigate association morningness-eveningness with behavioral health aspects a sample undergraduate students. We assessed demographic data; Pittsburgh Sleep Quality Index used evaluate sleep quality; Morningness/Eveningness Questionnaire determine morningness-eveningness, Self-Reporting assess minor psychiatric disorders. A total 372 students...
Abstract Using genome-wide data from 697,828 research participants 23andMe and UK Biobank, we increase the number of identified loci associated with being a morning person, behavioural indicator person’s underlying circadian rhythm, 24 to 351. 85,760 individuals activity-monitor derived measures sleep timing show that chronotype influence timing: mean 5% carrying most “morningness” alleles was 25 minutes earlier than fewest. The were enriched for genes involved in regulation, cAMP, glutamate...
Genome-wide association studies (GWAs) for type 2 diabetes (T2D) have been successful in identifying many loci with robust signals. Nevertheless, there is a clear need post-GWAs strategies to understand mechanism of action and clinical relevance these variants. The several comorbidities T2D suggests common etiology phenotypes complicates the management disease. In this study, we focused on genetics underlying relationships, using systems genomics identify genetic variation associated 12...
Abstract Butyrylcholinesterase activity has been shown to be positively associated with weight and body mass index (BMI). The present study was carried out search for an association between variants of the BCHE gene weight, stature, BMI on basis means variances compared nonusual their respective usual controls. Individuals bearing atypical mutation (N = 52) did not differ from phenotype controls 104) in these parameters. BCHE*U/BCHE*K individuals 222) presented a significantly higher...
Recognizing that insights into the modulation of sleep duration can emerge by exploring functional relationships among genes, we used this strategy to explore genome-wide association results for trait. We detected two major signalling pathways (ion channels and ERBB family tyrosine kinases) could be replicated across independent GWA studies meta-analyses. To investigate significance these modulation, performed transcriptome analyses short sleeping flies' heads (knockdown ABCC9 gene homolog;...
Abstract Disrupted circadian rhythms and reduced sleep duration are associated with several human diseases, particularly obesity type 2 diabetes, but little is known about the genetic factors influencing these heritable traits. We performed genome-wide association studies of self-reported chronotype (morning/evening person) in 128,266 White British individuals from UK Biobank study. Sixteen variants were ( P <5x10 -8 ), including near rhythm genes RGS16 (1.21 odds morningness [95%CI 1.15,...
Researchers are increasingly studying cognitive and psychological constructs using automated online tools due to advantages in scalability, repeatability, accessibility affordability. The assessment of sleep presents a challenge, as the most popular instruments for reporting different aspects were originally designed be deployed under supervised conditions by trained personnel. Here, we develop validate Comprehensive Online Sleep Monitoring Scale (COSMOS), self-reported scale optimised...