A5002305410- Sleep and related disorders
- Circadian rhythm and melatonin
- Obesity, Physical Activity, Diet
- Pelvic and Acetabular Injuries
- Religious Studies and Spiritual Practices
- Folklore, Mythology, and Literature Studies
- Crime and Detective Fiction Studies
- Trauma and Emergency Care Studies
- Pregnancy-related medical research
- Dietary Effects on Health
- Sleep and Wakefulness Research
- Medical and Health Sciences Research
- Cognitive Abilities and Testing
- Genetic Associations and Epidemiology
- Maternal and Perinatal Health Interventions
- Health, Environment, Cognitive Aging
University of Exeter
2018-2022
Royal Devon and Exeter Hospital
2019
Abstract Being a morning person is behavioural indicator of person’s underlying circadian rhythm. Using genome-wide data from 697,828 UK Biobank and 23andMe participants we increase the number genetic loci associated with being 24 to 351. 85,760 individuals activity-monitor derived measures sleep timing find that chronotype associate timing: mean 5% carrying most morningness alleles 25 min earlier than fewest. The are enriched for genes involved in regulation, cAMP, glutamate insulin...
This paper reports many loci associated with chronotype (i.e. being a morning person or evening person) in genome-wide association study (GWAS) of 697, 828 participants from the UK Biobank and 23andMe cohorts. The link between sleep timing quality is well known. It was therefore interesting to assess whether these genes were also and/or quality.
Abstract Using genome-wide data from 697,828 research participants 23andMe and UK Biobank, we increase the number of identified loci associated with being a morning person, behavioural indicator person’s underlying circadian rhythm, 24 to 351. 85,760 individuals activity-monitor derived measures sleep timing show that chronotype influence timing: mean 5% carrying most “morningness” alleles was 25 minutes earlier than fewest. The were enriched for genes involved in regulation, cAMP, glutamate...
Rare variants in ten genes have been reported to cause Mendelian sleep conditions characterised by extreme duration or timing. These include familial natural short ( ADRB1 , DEC2/BHLHE41 GRM1 and NPSR1 ), advanced phase PER2 PER3 CRY2 CSNK1D TIMELESS ) delayed CRY1 ). The association of these with were usually based on clinically ascertained families, their effects when identified the population are unknown. We aimed determine traits large population-based cohorts. performed genetic analysis...
ABSTRACT Rare variants in ten genes have been reported to cause Mendelian sleep conditions characterised by extreme duration or timing. These include familial natural short ( ADRB1, DEC2/BHLHE41, GRM1 and NPSR1 ), advanced phase PER2, PER3, CRY2, CSNK1D TIMELESS ) delayed CRY1 ). The association of these with were usually based on clinically ascertained families, their effects when identified the population are unknown. We aimed determine traits large population-based cohorts. performed...
Abstract Editor’s Note: This article was originally published as part of a contribution to Frances Marshall’s (compiler) Those Beautiful Dames (Chicago, IL: Magic Inc, 1984). The has been revised, and incorporates new important information emphasise the late Victorian early Edwardian period. It basis for presentation at Third Visual Delights Conference University Sheffield in 2005. Notes 1. Mander, R. & Mitchenson, J. (1965) British Music Hall, Studio Vista, London. 2. Clarke, S. W. (2001)...
Just weeks following the fifth anniversary of landmark Montgomery v Lanarkshire Health Board Supreme Court judgment, Royal College Obstetricians and Gynaecologists (RCOG) has delivered fourth edition its Green-top guideline on forceps vacuum assisted births1. The irony this is not lost those who expected real change last year’s peer review consultation (19 physicians 6 maternity care organisations responded, including first two signatories letter). opens with a fundamental question: Can...