A5022779730- Obesity, Physical Activity, Diet
- Birth, Development, and Health
- Genetic Associations and Epidemiology
- Electromagnetic Fields and Biological Effects
- Neuroscience and Neural Engineering
- Cutaneous Melanoma Detection and Management
- Prenatal Screening and Diagnostics
- Transcranial Magnetic Stimulation Studies
- Cardiovascular Disease and Adiposity
- Circadian rhythm and melatonin
- Nonmelanoma Skin Cancer Studies
- Kruppel-like factors research
- Neural dynamics and brain function
- Gestational Diabetes Research and Management
- Cancer Risks and Factors
- Osteoarthritis Treatment and Mechanisms
- Epigenetics and DNA Methylation
- Sleep and related disorders
- Reproductive Biology and Fertility
- Congenital Anomalies and Fetal Surgery
- Fibroblast Growth Factor Research
- Neonatal Health and Biochemistry
- Ectopic Pregnancy Diagnosis and Management
- Gaussian Processes and Bayesian Inference
- Photoreceptor and optogenetics research
Nottingham City Hospital
2023-2024
Princeton University
1985-2023
University of Exeter
2017-2021
MRC Epidemiology Unit
2019-2021
University of Bristol
2019-2021
Royal Devon and Exeter Hospital
2017-2019
Royal Liverpool University Hospital
2019
University of Liverpool
2019
Marian University - Indiana
2019
Tuskegee University
2010
Abstract Being a morning person is behavioural indicator of person’s underlying circadian rhythm. Using genome-wide data from 697,828 UK Biobank and 23andMe participants we increase the number genetic loci associated with being 24 to 351. 85,760 individuals activity-monitor derived measures sleep timing find that chronotype associate timing: mean 5% carrying most morningness alleles 25 min earlier than fewest. The are enriched for genes involved in regulation, cAMP, glutamate insulin...
Depression is more common in obese than non-obese individuals, especially women, but the causal relationship between obesity and depression complex uncertain. Previous studies have used genetic variants associated with BMI to provide evidence that higher body mass index (BMI) causes depression, not tested whether this driven by metabolic consequences of nor for differences men women.We performed a Mendelian randomization study using 48 791 individuals 291 995 controls UK Biobank, test...
Systematic reviews of randomised controlled trials (RCTs) have suggested that maternal vitamin D (25[OH]D) and calcium supplementation increase birth weight. However, limitations many were highlighted in the reviews. Our aim was to combine genetic RCT data estimate causal effects these two traits on offspring weight.We performed two-sample mendelian randomisation (MR) using instrumental variables associated with 25(OH)D had been identified genome-wide association studies (GWAS; sample 1; N =...
Statistical criteria in the interpretation of epidemiologic data. W D ThompsonCopyRight https://doi.org/10.2105/AJPH.77.2.191 Published Online: October 07, 2011
PURPOSE: To compare the effect of pathologic sentinel lymph node (SLN) status with that other known prognostic factors on recurrence and survival in patients stage I or II cutaneous melanoma. PATIENTS AND METHODS: We reviewed records 612 primary melanoma who underwent lymphatic mapping SLN biopsy between January 1991 May 1995 to determine effects tumor thickness, ulceration, Clark level, location, sex, disease-free disease-specific survival. RESULTS: In 580 whom were successful, was positive...
Three cases of congenital leukaemia associated with hydrops and intrauterine death are described. The leukaemic infiltrates, which involved both the infants placentas, were monocytic, lymphoblastic, myeloblastic types, respectively. general lack recognition condition is probably due to inadequate histological examination stillborn infant placenta.
Abstract Our aim was to investigate relative contributions of central and peripheral mechanisms knee osteoarthritis (OA) diagnosis their independent causal association with OA. We performed longitudinal analysis using data from UK-Biobank participants. Knee OA defined International Classification Diseases manual 10 codes participants' hospital records. Central were proxied multisite chronic pain (MCP) body mass index (BMI). Odds ratios (ORs) 95% confidence intervals (CIs) estimated,...
Abstract Using genome-wide data from 697,828 research participants 23andMe and UK Biobank, we increase the number of identified loci associated with being a morning person, behavioural indicator person’s underlying circadian rhythm, 24 to 351. 85,760 individuals activity-monitor derived measures sleep timing show that chronotype influence timing: mean 5% carrying most “morningness” alleles was 25 minutes earlier than fewest. The were enriched for genes involved in regulation, cAMP, glutamate...
20 male albino rats were used as Ss in determining behavioral effects of ultra high frequency radiation. Experimental exposed to low intensity (50,000 mV), (300 mc 920 mc) UHF radio waves for 47 consecutive days. Radiated more active than non-radiated during the early part experiment, but became less days radiation increased. The group was emotional non-UHF and showed a gradual increase latency recovery from electroshock convulsion. No differences found weight, audiogenic seizures, water...
Higher maternal BMI during pregnancy is associated with higher offspring birthweight, but it not known whether this solely the result of adverse metabolic consequences adiposity, such as insulin resistance and fetal exposure to glucose levels, or there any effect raised adiposity through non-metabolic (e.g. mechanical) factors. We aimed use genetic variants predispose coupled a favourable profile, in Mendelian randomisation (MR) study comparing 'metabolically adiposity' on birthweight...
The utility of endovascular techniques has expanded greatly over the past decade. Physicians now have choices regarding treatment many injuries that traditionally required open surgical repair. Technological advances in materials as well improved training and expertise among practitioners led to increased availability procedures can often provide an effective less invasive means management. following case report describes successful a traumatic blunt injury innominate artery using...
On the comparison of effects. W D ThompsonCopyRight https://doi.org/10.2105/AJPH.77.4.491 Published Online: October 07, 2011