Elina Hyppönen
A5026971838- Genetic Associations and Epidemiology
- Vitamin D Research Studies
- Birth, Development, and Health
- Nutrition, Genetics, and Disease
- Pregnancy and preeclampsia studies
- Gestational Diabetes Research and Management
- Obesity, Physical Activity, Diet
- Diet and metabolism studies
- Nutritional Studies and Diet
- Diabetes and associated disorders
- Liver Disease Diagnosis and Treatment
- Genetic and phenotypic traits in livestock
- Vitamin C and Antioxidants Research
- Genetics and Neurodevelopmental Disorders
- Genetic Mapping and Diversity in Plants and Animals
- Health, Environment, Cognitive Aging
- Digestive system and related health
- Folate and B Vitamins Research
- Cardiovascular Disease and Adiposity
- Bone health and osteoporosis research
- Lipoproteins and Cardiovascular Health
- Epigenetics and DNA Methylation
- Eating Disorders and Behaviors
- Adipose Tissue and Metabolism
- Coffee research and impacts
University of South Australia
2016-2025
South Australian Health and Medical Research Institute
2016-2025
Great Ormond Street Hospital
2015-2024
University College London
2015-2024
Lancaster University
2017
Farr Institute
2017
Eli Lilly (United Kingdom)
2016
Imperial College London
2016
University of Birmingham
2016
Islamic Azad University, Tehran
2016
Genetic factors increase risk of dementia, but the extent to which this can be offset by lifestyle is unknown.To investigate whether a healthy associated with lower dementia regardless genetic risk.A retrospective cohort study that included adults European ancestry aged at least 60 years without cognitive impairment or baseline. Participants joined UK Biobank from 2006 2010 and were followed up until 2016 2017.A polygenic score for low (lowest quintile), intermediate (quintiles 2 4), high...
A scavenger that protects the heart Coronary disease is a tale of two forms plasma cholesterol. In contrast to well-established effects “bad” cholesterol (LDL-C), role “good” (HDL-C) mysterious. Elevated HDL-C correlates with lower risk disease, yet drugs raise levels do not reduce risk. Zanoni et al. found some people exceptionally high carry rare sequence variant in gene encoding major receptor, receptor BI. This destroys receptor's ability take up HDL-C. Interestingly, this have higher...
Hypovitaminosis D and reduced IGF-1 are associated, individually, with metabolic syndrome. Physiological interactions between vitamin reported; this is the first study to investigate their combined associations syndrome prevalence.Data on 25-hydroxyvitamin (25(OH)D), IGF-1, abnormalities (abdominal obesity; raised A1C, blood pressure, triglycerides; low HDL cholesterol) were collected from 6,810 British white subjects in 1958 cohort, surveyed during 2002-2004 (age 45 years).IGF-1...
A bstract : Allergen‐induced secretion of Th2‐type cytokines and IgE production have recently been reported to be increased in mice treated with 1,25(OH) 2 D, the active form vitamin D. Our objective was investigate whether D supplementation infancy is associated risk atopy, allergic rhinitis, asthma. The Northern Finland Birth Cohort consists all individuals two most northern provinces who were due born 1966. Data on during first year life obtained 1967. Current asthma rhinitis at age 31...
Statin treatment and variants in the gene encoding HMG-CoA reductase are associated with reductions both concentration of LDL cholesterol risk coronary heart disease, but also modest hyperglycaemia, increased bodyweight, modestly type 2 diabetes, which no way offsets their substantial benefits. We sought to investigate associations cholesterol-lowering PCSK9 diabetes related biomarkers gauge likely effects inhibitors on risk.In this mendelian randomisation study, we used data from cohort...
Background: Vitamin D and calcium deficiencies are common worldwide, causing nutritional rickets osteomalacia, which have a major impact on health, growth, development of infants, children, adolescents; the consequences can be lethal or last into adulthood. The goals this evidence-based consensus document to provide health care professionals with guidance for prevention, diagnosis, management policy makers framework work toward its eradication. Evidence: A systematic literature search...
OBJECTIVE. Child abuse has been associated with poorer physical health in adulthood, but less is known about childhood adversity more broadly, including neglect and family problems, or the pathways from to adult disease. We have examined how different stressful emotional neglectful adversities are related adiposity glucose control midadulthood, taking into account factors, whether relationships mediated by behaviors socioeconomic position. METHODS. This was a prospective longitudinal study...
Background: The implications of different adiposity measures on cardiovascular disease etiology remain unclear. In this article, we quantify and contrast causal associations central (waist-to-hip ratio adjusted for body mass index [WHRadjBMI]) general (body [BMI]) with cardiometabolic disease. Methods: Ninety-seven independent single-nucleotide polymorphisms BMI 49 WHRadjBMI were used to conduct Mendelian randomization analyses in 14 prospective studies supplemented coronary heart (CHD) data...
Vitamin D deficiency (25-hydroxyvitamin [25(OH)D] <50 nmol/L) is commonly reported in both children and adults worldwide, growing evidence indicates that vitamin associated with many extraskeletal chronic disorders, including the autoimmune diseases type 1 diabetes multiple sclerosis.We measured 25(OH)D concentrations 720 case 2,610 control plasma samples genotyped single nucleotide polymorphisms from seven metabolism genes 8,517 case, 10,438 control, 1,933 family samples. We tested genetic...