M. Abdullah Said
A5027772162- Genetic Associations and Epidemiology
- Lipoproteins and Cardiovascular Health
- Obesity, Physical Activity, Diet
- Cardiac electrophysiology and arrhythmias
- Nutrition, Genetics, and Disease
- Diet, Metabolism, and Disease
- Cardiomyopathy and Myosin Studies
- Peroxisome Proliferator-Activated Receptors
- Cardiovascular Disease and Adiposity
- Heart Rate Variability and Autonomic Control
- Birth, Development, and Health
- Diabetes Treatment and Management
- Cardiovascular Health and Disease Prevention
- Heart rate and cardiovascular health
- Cancer, Lipids, and Metabolism
- Coffee research and impacts
- Alcohol Consumption and Health Effects
- Telomeres, Telomerase, and Senescence
- Cardiovascular Function and Risk Factors
- Heart Failure Treatment and Management
- Cardiovascular Health and Risk Factors
- Genetic Syndromes and Imprinting
- Congenital heart defects research
- Lipid metabolism and disorders
- Nuclear Receptors and Signaling
University Medical Center Groningen
2016-2024
University of Groningen
2016-2024
Universidade Federal de Minas Gerais
2019
Leiden University Medical Center
2019
Queen Mary University of London
2019
Dialyse Centrum Groningen
2017
Genetic and lifestyle factors both contribute to the risk of developing cardiovascular disease, but whether poor health behaviors are associated with similar increases in among individuals low, intermediate, or high genetic is unknown.To investigate association combined within groups coronary artery atrial fibrillation, stroke, hypertension, type 2 diabetes as well interactions between lifestyle.The UK Biobank cohort study includes more than 500 000 participants aged 40 70 years who were...
Statin treatment and variants in the gene encoding HMG-CoA reductase are associated with reductions both concentration of LDL cholesterol risk coronary heart disease, but also modest hyperglycaemia, increased bodyweight, modestly type 2 diabetes, which no way offsets their substantial benefits. We sought to investigate associations cholesterol-lowering PCSK9 diabetes related biomarkers gauge likely effects inhibitors on risk.In this mendelian randomisation study, we used data from cohort...
Vascular aging results in stiffer arteries and may have a role the development of cardiovascular disease (CVD). Arterial stiffness index (ASI), measured by finger photoplethysmography, pulse pressure (PP) are 2 independent vascular indices. We investigated whether ASI or PP predict new-onset CVD mortality large community-based population.We studied 169 613 UK Biobank participants (mean age 56.8 years; 45.8% males) who underwent measurement blood for calculation. Mean±SD was 9.30±3.1 m/s...
Objective: To determine the spectrum of phenotypes linked to ABO blood group system, using genetic determinants system. Approach and Results: We assessed risk 41 health disease outcomes, 36 linear traits associated with system in UK Biobank cohort. A total 406 755 unrelated individuals were included this study. Blood groups A, B, O determined based on allele combinations previously established single-nucleotide polymorphisms rs8176746, rs8176719 gene. Group AB was excluded because its...
Abstract Leisure sedentary behaviours are associated with increased risk of cardiovascular disease, but whether this relationship is causal unknown. The aim study to identify genetic determinants leisure and estimate the potential effect on coronary artery disease (CAD). Genome wide association analyses television watching, computer use driving behaviour in UK Biobank 145, 36 4 loci ( P < 1×10 −8 ), respectively. High correlations observed between neurological traits, including education...
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Abstract Background We characterised the phenotypic consequence of genetic variation at PCSK9 locus and compared findings with recent trials pharmacological inhibitors PCSK9. Methods Published individual participant level data (300,000+ participants) were combined to construct a weighted gene-centric score (GS). Seventeen randomized placebo controlled inhibitor included, providing on 79,578 participants. Results scaled one mmol/L lower LDL-C concentration. The GS (comprising 4 SNPs)...
Background Caffeine is the most widely consumed psychostimulant and associated with lower risk of coronary artery disease (CAD) type 2 diabetes mellitus (T2DM). However, whether these associations are causal remains unknown. This study aimed to identify genetic variants caffeine intake, investigate evidence for links CAD or T2DM. In addition, we replicate previous observational findings. Methods Results Observational were tested within UK Biobank using Cox regression analyses. Moderate...
Alterations in the anatomic and biomechanical properties of ascending aorta (AAo) can give rise to various vascular pathologies. The aim current study is gain additional insights biology AAo size function.
Smoking is associated with shorter leucocyte telomere length (LTL), a biomarker of increased morbidity and reduced longevity. This association widely interpreted as evidence that smoking causes accelerated LTL attrition in adulthood, but the for this inconsistent. We analysed between dynamics 18 longitudinal cohorts. The dataset included data from 12 579 adults (4678 current smokers 7901 non-smokers) over mean follow-up interval 8.6 years. Meta-analysis confirmed cross-sectional difference...
We aimed to estimate the effects of a lifelong exposure high systolic blood pressure (SBP) on left ventricular (LV) structure and function using Mendelian randomization. A total 5596 participants UK Biobank were included for whom cardiovascular magnetic resonance imaging genetic data available. Major exclusion criteria nonwhite ethnicity, major disease, body mass index >30 or <18.5 kg/m 2 . risk score genetically predicted SBP (gSBP) was constructed based 107 previously established...
We aimed to study the association of very low serum Lipoprotein(a) [Lp(a)] concentrations with new-onset type 2 diabetes (T2D) and non-alcoholic liver disease (NAFLD) in context statin usage UK Biobank, a large prospective population cohort.