A5086050631- Genetic Associations and Epidemiology
- Lipoproteins and Cardiovascular Health
- Pharmacogenetics and Drug Metabolism
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Emergency and Acute Care Studies
- Trauma and Emergency Care Studies
- Clinical practice guidelines implementation
- Antiplatelet Therapy and Cardiovascular Diseases
- Obesity, Physical Activity, Diet
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Systems, Economic Evaluations, Quality of Life
- Renal and related cancers
- Gastrointestinal motility and disorders
- Respiratory viral infections research
- Eicosanoids and Hypertension Pharmacology
- Asthma and respiratory diseases
- Celiac Disease Research and Management
- Nutritional Studies and Diet
- Neuroscience of respiration and sleep
- Delphi Technique in Research
- Neuroendocrine regulation and behavior
- Whipple's Disease and Interleukins
- Frailty in Older Adults
- Sodium Intake and Health
- Network Time Synchronization Technologies
Hunter Medical Research Institute
2013-2024
University of Newcastle Australia
2015-2024
La Trobe University
2022
John Hunter Hospital
2022
University Hospital Kerry
2022
Ordnance Survey
2022
National Health and Medical Research Council
2021
University of Sheffield
2018
Creative Research Enterprises (United States)
2015
Taipei Medical University
2015
Statin treatment and variants in the gene encoding HMG-CoA reductase are associated with reductions both concentration of LDL cholesterol risk coronary heart disease, but also modest hyperglycaemia, increased bodyweight, modestly type 2 diabetes, which no way offsets their substantial benefits. We sought to investigate associations cholesterol-lowering PCSK9 diabetes related biomarkers gauge likely effects inhibitors on risk.In this mendelian randomisation study, we used data from cohort...
Background: The relationship between overweight or obesity and depressive symptoms in individuals with without cardio-metabolic abnormalities is unclear. In a cross-sectional study we examined the odds of experiencing obese older adults metabolic abnormalities. Methods: participants included 3318 from Hunter Community Study Cohort Body Mass Index (BMI) ≥ 18.5 kgm2, stratified by BMI health risk. Obesity was defined as 30 kgm2 metabolically healthy absence risk factors, according to...
Abstract Background We characterised the phenotypic consequence of genetic variation at PCSK9 locus and compared findings with recent trials pharmacological inhibitors PCSK9. Methods Published individual participant level data (300,000+ participants) were combined to construct a weighted gene-centric score (GS). Seventeen randomized placebo controlled inhibitor included, providing on 79,578 participants. Results scaled one mmol/L lower LDL-C concentration. The GS (comprising 4 SNPs)...
The aim of this research is to estimate the prevalence excessive daytime sleepiness in an older population and associations with sociodemographic, health, lifestyle factors using a cross-sectional, population-based study. Participants were men (1560) women (1759), aged 55 85 years, enrolled Hunter Community Study, longitudinal study aging. Measurements self-reported questionnaires, biochemical measures, clinical measures. Of 3319 participants, 3053 participants completed Epworth Sleepiness...
Aim To determine if there is a difference in serum zinc concentration between normoglycaemic, pre-diabetic and type-2 diabetic groups this associated with pancreatic beta cell function insulin sensitivity the former 2 groups. Method Cross sectional study of random sample older community-dwelling men women Newcastle, New South Wales, Australia. Beta function, resistance were calculated for normoglycaemic prediabetes participants using Homeostasis Model Assessment (HOMA-2) calculator. Result A...
BACKGROUND: Hypertension is a key risk factor for major adverse cardiovascular events but remains difficult to treat in many individuals. Dietary interventions are an effective approach lower blood pressure (BP) not equally across all BP heritable, and genetics may be useful tool overcome treatment response heterogeneity. We investigated whether the of could used identify individuals with hypertension who receive particular benefit from lowering sodium intake boosting potassium levels....
Measures of lung function are heritable, and thus, we sought to utilise genetics propose drug-repurposing candidates that could improve respiratory outcomes. Lung measures were found be genetically correlated with seven druggable biochemical traits, further evidence a causal relationship between increased fasting glucose diminished function. Moreover, developed polygenic scores for specifically within pathways known drug targets investigated their pulmonary phenotypes gene expression in...
no studies have compared the predictive validity of different dementia risk prediction models in Australia.
Rationale Methylarginines are endogenous nitric oxide synthase inhibitors that have been implicated in animal models of lung disease but not previously examined for their association with spirometric measures function humans. Objectives This study measured serum concentrations asymmetric and symmetric dimethylarginine a representative sample older community-dwelling adults determined measures. Methods Data on clinical, lifestyle, demographic characteristics, methylated arginines, L-arginine...
Previously thought to be mainly a disorder of childhood and early adult life, coeliac disease (CeD) is increasingly diagnosed in older adults. This may important given the association between CeD osteoporosis. The primary aim this study was determine seroprevalence undiagnosed (‘at-risk serology’) an Australian community relate diagnosis osteoporosis fractures during follow-up period 12 years. We included participants from Hunter Community Study (2004⁻2007) aged 55⁻85, who had...
To investigate whether polymorphisms of the cyclo-oxygenase-2 (COX-2) gene modify adverse cardiovascular effects COX-2 inhibitors.A case control study was conducted in Hunter Region New South Wales, Australia. Cases (n= 460) were hospitalized with acute coronary syndrome (ACS). Controls 640) recruited from electoral rolls. Structured interviews gathered information on variables including recent ingestion non-steroidal anti-inflammatory drugs (NSAIDs). Targeted genotyping rs 20417(G > C) and...
Winskill R, Keatinge D, Hancock S. International Journal of Nursing Practice 2011; 17 : 126–132 Influences on parents' decisions when determining whether their child is sick and what they do about it: A pilot study Parents frequently find it difficult to decide sick, how is, if should seek medical advice. The presence fever appears be one influence, less known other behaviours, signs symptoms which might guide decisions. This exploratory descriptive aimed gain an understanding the factors...
Abstract Introduction Prolonged use of systemic corticosteroids leads to reduced bone mineral density and osteoporosis, in turn increasing the risk minimal trauma fractures with their associated morbidity mortality elderly populations. However, effect inhaled on has been debated medical literature. Objectives We aimed determine measured using calcaneal quantitative ultrasonography a cohort older Australians. Methods Data was collected from Hunter Community Study, longitudinal Australians...
Abstract Background We characterised the phenotypic consequence of genetic variation at PCSK9 locus and compared findings with recent trials pharmacological inhibitors PCSK9. Methods Published individual participant level data (300,000+ participants) were combined to construct a weighted gene-centric score (GS). Fourteen randomized placebo controlled inhibitor included, providing on 79,578 participants. Results scaled one mmol/L lower LDL-C concentration The GS (comprising 4 SNPs)...
Background: Few studies have explored the links between adiposity, metabolic health, and lung function. This study examined cross-sectional association spirometric function overweight/obesity, with without abnormalities, in older adults. Methods: The research involved 3,318 adults from Hunter Community Study Cohort who had a BMI of 18.5 kg/m2 or higher. Participants were grouped based on health risk. Obesity was defined as 30 more, while determined by absence risk factors according to...
This study analyzed clinically actionable pharmacogenotypes for clopidogrel, warfarin, statins, thiopurines, and tacrolimus using microarray data 2121 participants (55-85 years) from the Australian Hunter Community Study (HCS). At least 74% of (95% confidence interval [CI]: 72%-76%) had strong level evidence at one medium- or high-risk genotype that would trigger a change in standard therapy under current international recommendations. About 14% these CI: 12%-16%) were taking medication...