A5023567978- Cystic Fibrosis Research Advances
- Bacterial biofilms and quorum sensing
- Bacterial Identification and Susceptibility Testing
- Pediatric health and respiratory diseases
- Tracheal and airway disorders
- Respiratory viral infections research
- Antimicrobial Resistance in Staphylococcus
- Antibiotic Resistance in Bacteria
- Nosocomial Infections in ICU
- Gut microbiota and health
- Pneumonia and Respiratory Infections
- SARS-CoV-2 detection and testing
- Animal Virus Infections Studies
- Biosensors and Analytical Detection
- Inhalation and Respiratory Drug Delivery
- Enterobacteriaceae and Cronobacter Research
- Neonatal Respiratory Health Research
- Viral gastroenteritis research and epidemiology
- Bacterial Infections and Vaccines
- Mycobacterium research and diagnosis
- Vibrio bacteria research studies
- Antibiotic Use and Resistance
- Transplantation: Methods and Outcomes
- Clostridium difficile and Clostridium perfringens research
- Respiratory and Cough-Related Research
Queen's University Belfast
2015-2024
Queens University
2023
UNSW Sydney
2018
Wolters Kluwer Health
2016
Rigshospitalet
2015
University of Copenhagen
2015
University of North Carolina at Chapel Hill
2015
University of North Carolina Health Care
2015
Leeds Teaching Hospitals NHS Trust
2015
University of Calgary
2013
Pulmonary infection in cystic fibrosis (CF) is polymicrobial and it possible that anaerobic bacteria, not detected by routine aerobic culture methods, reside within infected airway mucus.To determine whether bacteria are present the sputum of patients with CF.Sputum samples were collected from clinically stable adults CF bronchoalveolar lavage fluid (BALF) children CF. Induced healthy volunteers who did have All processed using bacteriologic techniques quantified identified.Anaerobic species...
Cystic fibrosis (CF) is characterized by defective mucociliary clearance and chronic airway infection a complex microbiota. Infection, persistent inflammation periodic episodes of acute pulmonary exacerbation contribute to an irreversible decline in CF lung function. While the factors leading exacerbations are poorly understood, antibiotic treatment can temporarily resolve symptoms partially restore Previous studies indicated that may be associated with changes microbial densities...
<h3>Background</h3> Anaerobic bacteria are increasingly regarded as important in cystic fibrosis (CF) pulmonary infection. The aim of this study was to determine the effect antibiotic treatment on aerobic and anaerobic microbial community diversity abundance during exacerbations patients with CF. <h3>Methods</h3> Sputum collected at start completion when clinically stable. Bacteria were quantified identified following culture, composition also examined using culture-independent methods....
Contamination of medical devices with bacteria such as Meticillin resistant Staphylococcus aureus (MRSA) is great clinical concern. Poly(vinyl chloride) widely used in the production devices, catheters. The flexibility catheter tubing derived from addition plasticisers. Here, we report design two dual functional ionic liquids, 1-ethylpyridinium docusate and tributyl(2-hydroxyethyl)phosphonium docusate, which uniquely provide a plasticising effect, exhibit antimicrobial antibiofilm-forming...
OBJECTIVES: To determine the prevalence of, and factors associated with, methicillin‐resistant Staphylococcus aureus (MRSA) colonization in residents staff nursing homes one geographically defined health administration area of Northern Ireland. DESIGN: Point study. SETTING: Nursing homes. PARTICIPANTS: Residents MEASUREMENTS: Nasal swabs were taken from all consenting staff. If relevant, also provided urine samples, wounds indwelling devices. RESULTS: A total 1,111 (66% residents) 553 (86%...
Bacteria have been extensively implicated in the development of smoking related diseases, such as COPD, by either direct infection or bacteria-mediated inflammation. In response to health risks associated with tobacco exposure, use electronic cigarettes (e-cigs) has increased. This study compared effect e-cig vapour (ECV) and cigarette smoke (CSE) on virulence inflammatory potential key lung pathogens (Haemophilus influenzae, Streptococcus pneumoniae, Staphylococcus aureus Pseudomonas...
As of 8 July 2022, the World Health Organization (WHO) have reported 1010 probable cases acute hepatitis unknown aetiology in children worldwide, including approximately 250 United Kingdom (UK). Clinical presentations often been severe, with liver transplantation a frequent clinical outcome. Human adenovirus F41 (HAdV-F41) has detected most hepatitis, but its role pathogenesis this infection yet to be established. Wastewater-based epidemiology (WBE) become well-established tool for...
The susceptibility of Staphylococcus aureus [meticillin-resistant (MRSA) and meticillin-sensitive (MSSA)] coagulase-negative staphylococci (CoNS), which respectively form part the transient commensal skin flora, to tea-tree oil (TTO) was compared using broth microdilution quantitative in vitro time–kill test methods. MRSA MSSA isolates were significantly less susceptible than CoNS isolates, as measured by both MIC minimum bactericidal concentration. A significant decrease mean viable count...
The purpose of this study was to determine serum profiles cytokines at a protein level and Creactive (CRP) during the development postweaning multisystemic wasting syndrome (PMWS) in experimentally inoculated pigs. Levels IFN-α, IL-6, IL-10, CRP were examined for 35-day period 10 piglets infected with PCV2 3 weeks age. Four developed severe PMWS 14 21 days post-infection (d.p.i.) died prior termination experiment. remaining six PCV2-infected experienced transient fever, but did not display...
ObjectivesTo compare the antimicrobial susceptibility of Prevotella spp. isolated from cystic fibrosis (CF) and non-CF patients analyse impact antibiotic prescribing in preceding year on resistance amongst CF isolates.
Purpose. The purpose of this study was to develop an alternative, more clinically relevant approach susceptibility reporting for implant-associated infections. Using 20 staphylococcal isolates, isolated from clinical implant infections, the majority (85 %) demonstrated biofilm-forming capabilities. A significantly increased minimum biofilm eradication concentration (MBEC) compared inhibitory (MIC) breakpoint obtained, with MBEC values greater than 256 µg ml−1 bacteria. Such a vast increase...
To investigate the effect of sub-lethal challenge with tea tree oil (TTO) on antibiotic resistance profiles staphylococci.Isolates methicillin-resistant/-sensitive Staphylococcus aureus (MRSA and MSSA) coagulase-negative staphylococci (CONS) were habituated to concentrations TTO (72 h). Following habituation, minimum inhibitory (MIC) antibiotics determined. Habituated MRSA/MSSA cultures had higher (P < 0.05) MIC values than control for examined antibiotics. also displayed decreased...
The objective was to determine the in vitro antimicrobial susceptibility of Pseudomonas aeruginosa isolates cultured from cystic fibrosis (CF) patients and explore associations between strain sequence type susceptibility. Fourteen antibiotics antibiotic combinations, including novel antibacterial peptide murepavadin, were tested for activity against 414 respiratory samples CF patients.
Respiratory syncytial virus (RSV) causes severe infections in infants, immunocompromised or elderly individuals resulting annual epidemics of respiratory disease. Currently, limited clinical surveillance and the lack predictable seasonal dynamics limit public health response. Wastewater-based epidemiology (WBE) has recently been used globally as a key metric determining prevalence acute syndrome coronavirus 2 community, but its application to other viruses is limited. In this study, we...
Research in residential homes has been limited to date and the extent of systemic topical antimicrobial prescribing is largely unknown. The aim this study was investigate Northern Ireland (NI). Point prevalence studies (PPSs) were completed November 2010 (PPS1) April 2011 (PPS2) 30 homes. Data obtained from care plans, medication administration records staff relation facility resident characteristics, analysed descriptively. point 9.4% PPS1 9.2% PPS2 (range 0.0%–33.3% during both PPSs)....
ObjectivesTo investigate mechanisms of reduced susceptibility to commonly used antibiotics in Prevotella cultured from patients with cystic fibrosis (CF), invasive infection and healthy control subjects determine whether genotype can be predict phenotypic resistance.
Two ionic liquids, 1-ethylpyridinium docusate (IL1) and tri-n-butyl(2-hydroxyethyl)phosphonium (IL2), were designed synthesized with the explicit intention of imparting a combination plasticization antimicrobial efficacy when incorporated into medical grade poly(vinyl chloride)s (PVCs). The glass transition (Tg) PVC can be reduced by >20 °C on addition 15 wt% IL2. Both IL1 IL2 leached to varying extents from base resins rendering surface PVCs hydrophilic. activity both ILs is related...