A5029738421- Health Systems, Economic Evaluations, Quality of Life
- Pharmaceutical Economics and Policy
- Pharmaceutical industry and healthcare
- Inflammatory mediators and NSAID effects
- Primary Care and Health Outcomes
- Blood transfusion and management
- Healthcare Policy and Management
- Pharmaceutical Practices and Patient Outcomes
- Pharmaceutical studies and practices
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Healthcare cost, quality, practices
- Meta-analysis and systematic reviews
- Health and Medical Research Impacts
- Health Sciences Research and Education
- Drug-Induced Adverse Reactions
- Rhetoric and Communication Studies
- Health disparities and outcomes
- Antiplatelet Therapy and Cardiovascular Diseases
- Helicobacter pylori-related gastroenterology studies
- Healthcare Systems and Technology
- Potassium and Related Disorders
- Pharmacogenetics and Drug Metabolism
- Asthma and respiratory diseases
- Heart Failure Treatment and Management
- Ethics in Clinical Research
Bond University
2017-2025
UNSW Sydney
2006-2025
Australian Federation of Graduate Women New South Wales
2025
National Health and Medical Research Council
2022-2024
University of Pittsburgh
2024
United States Air Force Academy
2024
Center for Clinical Research (United States)
2024
Center for the Neural Basis of Cognition
2024
Gold Coast Hospital
2020-2023
Montefiore Medical Center
2021
Non-randomised studies of the effects interventions are critical to many areas healthcare evaluation, but their results may be biased. It is therefore important understand and appraise strengths weaknesses. We developed ROBINS-I ("Risk Of Bias In Studies - Interventions"), a new tool for evaluating risk bias in estimates comparative effectiveness (harm or benefit) from that did not use randomisation allocate units (individuals clusters individuals) comparison groups. The will particularly...
GRADE Working Group (oxman{at}online.no)Informed Choice Research Department, Norwegian Health Services Centre, PO Box 7004, St Olavs Plass, 0130 Oslo, NorwayCorrespondence to: Andrew D Oxman,Accepted 5 March 2004
The number of published systematic reviews studies healthcare interventions has increased rapidly and these are used extensively for clinical policy decisions. Systematic subject to a range biases increasingly include non-randomised interventions. It is important that users can distinguish high quality reviews. Many instruments have been designed evaluate different aspects reviews, but there few comprehensive critical appraisal instruments. AMSTAR was developed randomised trials. In this...
A number of approaches have been used to grade levels evidence and the strength recommendations. The use many different detracts from one main reasons for having explicit approaches: concisely characterise communicate this information so that it can easily be understood thereby help people make well-informed decisions. Our objective was critically appraise six prominent systems grading recommendations as a basis agreeing on characteristics common, sensible approach recommendations.Six were...
<b>Background:</b> Most proton pump inhibitors inhibit the bioactivation of clopidogrel to its active metabolite. The clinical significance this drug interaction is unknown. <b>Methods:</b> We conducted a population-based nested case–control study among patients aged 66 years or older who commenced between Apr. 1, 2002, and Dec. 31, 2007, following hospital discharge after treatment acute myocardial infarction. cases in our were those readmitted with infarction within 90 days discharge....
Evidence is mounting that medicine harming healthy people through ever earlier detection and wider definition of disease. With the announcement an international conference to improve understanding problem overdiagnosis, Ray Moynihan , Jenny Doust David Henry examine its causes explore solutions
Recent reports suggest that existing antihypertensive agents may not have sufficient efficacy to control blood pressure (BP) in many patients. Omapatrilat, an agent under development, has been shown significantly greater than agents, but also carry increased risk of angioedema. We compared the and safety omapatrilat a representative angiotensin-converting enzyme (ACE) inhibitor, enalapril. The Omapatrilat Cardiovascular Treatment vs. Enalapril (OCTAVE) trial is multicenter, randomized,...
<h3>Background</h3> Experimental studies have shown that administration of nonsteroidal anti-inflammatory drugs (NSAIDs) to susceptible individuals can lead the development congestive heart failure (CHF). There been few epidemiological investigations importance this adverse effect. <h3>Objective</h3> To estimate relative risk first admission a hospital with CHF in recent users NSAIDs, compared nonusers, and determine whether estimated was increased those history disease extent which level...
The news media are an important source of information about new medical treatments, but there is concern that some coverage may be inaccurate and overly enthusiastic.
Ritonavir is a potent inhibitor in vitro of human immunodeficiency virus type 1 (HIV-1) protease, which needed for virions to mature and become infective. We assessed the safety efficacy ritonavir patients with HIV-1 infection.
Tranexamic acid reduces surgical bleeding and death due to in patients with trauma. Meta-analyses of small trials show that tranexamic might decrease deaths from gastrointestinal bleeding. We aimed assess the effects
<h3>Background:</h3> Characterizing high-cost users of health care resources is essential for the development appropriate interventions to improve management these patients. We sought determine concentration spending, characterize demographic characteristics and clinical diagnoses examine consistency their consumption over time. <h3>Methods:</h3> conducted a retrospective analysis all residents Ontario, Canada, who were eligible publicly funded between 2009 2011. estimated total attributable...
Disseminated infection with Mycobacterium avium complex is the most common opportunistic in patients advanced stages of acquired immunodeficiency syndrome (AIDS). We studied efficacy and safety prophylactic treatment clarithromycin, a macrolide antibiotic.
The Guest Editors of the Disease Mongering theme issue argue that we need better research to identify, understand, and combat threat human health from corporate-sponsored selling sickness.