A5011877915- Acute Myocardial Infarction Research
- Cardiac Imaging and Diagnostics
- Heart Failure Treatment and Management
- Coronary Interventions and Diagnostics
- Health Systems, Economic Evaluations, Quality of Life
- Atrial Fibrillation Management and Outcomes
- Lipoproteins and Cardiovascular Health
- Cardiac Valve Diseases and Treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac Health and Mental Health
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiac Arrest and Resuscitation
- Emergency and Acute Care Studies
- Healthcare cost, quality, practices
- Infective Endocarditis Diagnosis and Management
- Healthcare Policy and Management
- Cardiovascular Function and Risk Factors
- Cardiac Arrhythmias and Treatments
- Pharmaceutical Economics and Policy
- Venous Thromboembolism Diagnosis and Management
- Medication Adherence and Compliance
- Cardiovascular Health and Risk Factors
- Health Promotion and Cardiovascular Prevention
- Cardiac pacing and defibrillation studies
- Cardiac electrophysiology and arrhythmias
University of Toronto
2016-2025
Health Sciences Centre
2016-2025
Institute for Clinical Evaluative Sciences
2016-2025
Sunnybrook Health Science Centre
2016-2025
Sunnybrook Hospital
2007-2025
Wonkwang University
2025
University Health Network
2014-2024
Sunnybrook Research Institute
2017-2024
Vanderbilt University Medical Center
2024
University of California, Los Angeles
2024
Acute myocardial infarction can be triggered by acute respiratory infections. Previous studies have suggested an association between influenza and infarction, but those used nonspecific measures of infection or study designs that were susceptible to bias. We evaluated the laboratory-confirmed infarction.
To describe rates and risk factors for prolonged postoperative use of opioids in patients who had not previously used undergoing major elective surgery.Population based retrospective cohort study.Acute care hospitals Ontario, Canada, between 1 April 2003 31 March 2010.39,140 opioid naïve aged 66 years or older surgery, including cardiac, intrathoracic, intra-abdominal, pelvic procedures.Prolonged after discharge, as defined by ongoing outpatient prescriptions more than 90 days surgery.Of the...
<b>Background:</b> Most proton pump inhibitors inhibit the bioactivation of clopidogrel to its active metabolite. The clinical significance this drug interaction is unknown. <b>Methods:</b> We conducted a population-based nested case–control study among patients aged 66 years or older who commenced between Apr. 1, 2002, and Dec. 31, 2007, following hospital discharge after treatment acute myocardial infarction. cases in our were those readmitted with infarction within 90 days discharge....
The benefits of cardiovascular therapies such as statins for secondary prevention have been well documented, although they may not be optimally used in patients most likely to benefit. Ideally, aggressiveness the use these beneficial should correlate with baseline risk.To examine association between physicians' treatment and risk.Retrospective cohort study incorporating multiple linked health care administrative databases covering more than 1.4 million elderly residents Ontario. We included...
The placement of drug-eluting stents decreases the frequency repeat revascularization procedures in patients undergoing percutaneous coronary intervention (PCI) randomized clinical trials. However, there is uncertainty about effectiveness stents, and increasing concern their safety, routine practice.From Cardiac Care Network Ontario's population-based registry all PCI Ontario, Canada, we identified a well-balanced cohort 3751 pairs patients, matched on basis propensity score, who received...
Spontaneous coronary artery dissection (SCAD) was underdiagnosed and poorly understood for decades. It is increasingly recognized as an important cause of myocardial infarction (MI) in women. We aimed to assess the natural history SCAD, which has not been adequately explored. performed a multicentre, prospective, observational study patients with non-atherosclerotic SCAD presenting acutely from 22 centres North America. Institutional ethics approval patient consents were obtained. recorded...
The association between hospital volume and the death rate for patients who are hospitalized acute myocardial infarction, heart failure, or pneumonia remains unclear. It is also not known whether a threshold such an exists.We conducted cross-sectional analyses of data from Medicare administrative claims all fee-for-service beneficiaries were 2004 2006 in care hospitals United States pneumonia. Using hierarchical logistic-regression models each condition, we estimated change odds within 30...
The prognostic importance of high-density lipoprotein cholesterol (HDL-C) as a specific risk factor for cardiovascular (CV) disease has been challenged by recent clinical trials and genetic studies.This study sought to reappraise the association HDL-C level with CV non-CV mortality using "big data" approach.An observational cohort was conducted CANHEART (Cardiovascular Health in Ambulatory Care Research Team) dataset, which created linking together 17 different individual-level data sources....
<h3>Importance</h3> Health care services that support the hospital-to-home transition can improve outcomes in patients with heart failure (HF). <h3>Objective</h3> To test effectiveness of Patient-Centered Care Transitions HF transitional model hospitalized for HF. <h3>Design, Setting, and Participants</h3> Stepped-wedge cluster randomized trial 2494 adults across 10 hospitals Ontario, Canada, from February 2015 to March 2016, follow-up until November 2016. <h3>Interventions</h3> Hospitals...
Publicly released report cards on hospital performance are increasingly common, but whether they an effective method for improving quality of care remains uncertain.To evaluate the public release data cardiac indicators effectively stimulates hospitals to undertake improvement activities that improve health processes and patient outcomes.Population-based cluster randomized trial (Enhanced Feedback Effective Cardiac Treatment [EFFECT]) 86 corporations in Ontario, Canada, with patients...
Background— The CArdiovascular HEalth in Ambulatory care Research Team (CANHEART) is conducting a unique, population-based observational research initiative aimed at measuring and improving cardiovascular health the quality of ambulatory provided Ontario, Canada. A particular focus will be on identifying opportunities to improve primary secondary prevention events Ontario’s diverse multiethnic population. Methods Results— cohort comprising 9.8 million Ontario adults ≥20 years 2008 was...
Guidelines recommend that noncardiac surgery be delayed until 30 to 45 days after bare-metal stent implantation and 1 year drug-eluting implantation.We used linked registry data population-based administrative health care databases conduct a cohort study of 8116 patients (≥40 years age) who underwent major elective in Ontario, Canada between 2003 2009, received coronary stents within 10 before surgery. Approximately 34% (n=2725) insertion 2 surgery, whom 905 (33%) stents. For comparison, we...
Background— Out-of-hospital cardiac arrest (OHCA) is associated with a poor prognosis and poses significant burden to the healthcare system, but few studies have evaluated whether OHCA incidence survival changed over time. Methods Results— A population-based cohort study was conducted, including 34 291 patients >20 years of age who were transported alive emergency department an acute-care hospital from April 1, 2002, March 31, 2012, in Ontario, Canada. Patients life-threatening trauma...