A5048258734- Cardiac, Anesthesia and Surgical Outcomes
- Aortic aneurysm repair treatments
- Emergency and Acute Care Studies
- Sepsis Diagnosis and Treatment
- Aortic Disease and Treatment Approaches
- Aquatic Invertebrate Ecology and Behavior
- Fish Ecology and Management Studies
- HIV, Drug Use, Sexual Risk
- Respiratory Support and Mechanisms
- Adolescent Sexual and Reproductive Health
- HIV/AIDS Research and Interventions
- Healthcare Policy and Management
- Hepatitis C virus research
- Primary Care and Health Outcomes
- Computational Physics and Python Applications
- Global Health Care Issues
- Hemodynamic Monitoring and Therapy
- Cardiac Imaging and Diagnostics
- Statistical Methods in Clinical Trials
- Reproductive tract infections research
- Wildlife Ecology and Conservation
- Neonatal Respiratory Health Research
- Acute Myocardial Infarction Research
- Statistical Methods and Bayesian Inference
- Maternal and fetal healthcare
The Ohio State University
2023
Major League Baseball
2021
United States Fish and Wildlife Service
2006-2018
Intensive Care National Audit & Research Centre
2002-2006
Transnational Press London
2006
Imperial College London
1999-2005
MRC Clinical Trials Unit at UCL
2000-2004
MRC Biostatistics Unit
2001-2004
Charing Cross Hospital
2004
Columbia University
2004
Post-partum haemorrhage is the leading cause of maternal death worldwide. Early administration tranexamic acid reduces deaths due to bleeding in trauma patients. We aimed assess effects early on death, hysterectomy, and other relevant outcomes women with post-partum haemorrhage.In this randomised, double-blind, placebo-controlled trial, we recruited aged 16 years older a clinical diagnosis after vaginal birth or caesarean section from 193 hospitals 21 countries. randomly assigned receive...
Intervention to reduce abdominal aortic aneurysm (AAA) expansion and optimization of screening intervals would improve current surveillance programs. The aim this study was characterize AAA growth in a national cohort patients with both overall by cardiovascular risk factors.In study, 1743 were monitored for changes diameter ultrasonography over mean follow-up 1.9 years. Mean initial rate 43 mm (range 28 85 mm) 2.6 mm/year (95% range, -1.0 6.1 mm/year), respectively. Baseline strongly...
Two clinical trials, one British and American, have shown that early, prophylactic elective surgery does not improve five-year survival among patients with small abdominal aortic aneurysms. We report long-term outcomes in the United Kingdom Small Aneurysm Trial.We randomly assigned 1090 patients, 60 to 76 years of age, aneurysms (diameter, 4.0 5.5 cm) two groups: 563 were undergo early surgery, 527 surveillance by ultrasonography. Patients followed trial until June 1998 thereafter August...
Objective To investigate the numbers, clinical characteristics, resource use, and outcomes of admissions who met precise physiologic criteria for severe sepsis (as defined in PROWESS trial) first 24 hrs intensive care unit. Design Observational cohort study, with retrospective analysis prospectively collected data. Setting Ninety-one adult general units England, Wales, Northern Ireland between 1995 2000. Patients were 56,673 admissions. Interventions None. Measurements Main Results We found...
Tranexamic acid reduces surgical bleeding and death due to in patients with trauma. Meta-analyses of small trials show that tranexamic might decrease deaths from gastrointestinal bleeding. We aimed assess the effects
<h3>Abstract</h3> <b>Objective</b> To assess whether a nurse led, flow monitored protocol for optimising circulatory status in patients after cardiac surgery reduces complications and shortens stay intensive care hospital. <b>Design</b> Randomised controlled trial. <b>Setting</b> Intensive unit cardiothoracic of university teaching <b>Participants</b> 174 who underwent between April 2000 January 2003. <b>Interventions</b> Patients were allocated to conventional haemodynamic management or an...
on Intensive Care and Emergency Medicine seal is maintained by gentle pressure the TT keeping cuff pressing vocal cords.During percutaneous tracheostomy bougie remains in trachea.When ventilation through tube (cuff inflated) confirmed, are withdrawn.Throughout procedure, if difficulties occur, can be easily re-inserted using as a guide.Results Three different bougies were used: types (number used) Eschmann (29), size 10 Portex disposable (four) 12 (13).Three patients trauma cases: neutral...
Abstract Introduction The present paper describes the methods of data collection and validation employed in Intensive Care National Audit & Research Centre Case Mix Programme (CMP), a national comparative audit outcome for adult, critical care admissions. also case mix, activity admissions Database (CMPD). Methods CMP collects on consecutive to general units England, Wales Northern Ireland. Explicit steps are taken ensure accuracy data, including use dataset specification, initial...
Abstract Background In regional and population studies, the mortality rate within 30 days of elective surgical repair abdominal aortic aneurysm is approximately 8 per cent. Identification preoperative factors associated with this risk important for informing policy may suggest suitable interventions. Methods UK Small Aneurysm Trial, 820 patients aged 60–80 years underwent open an aneurysm. The relationship between 30-day 13 prespecified potential prognostic was investigated. value a...
To assess the performance of published risk prediction models in common use adult critical care United Kingdom and to recalibrate these a large representative database admissions.Prospective cohort study.A total 163 general units England, Wales, Northern Ireland, during period December 1995 August 2003.A 231,930 admissions, which 141,106 met inclusion criteria had sufficient data recorded for all models.None.The versions Acute Physiology Chronic Health Evaluation (APACHE) II, APACHE II UK,...
Abstract Prognostic models are designed to predict a clinical outcome in individuals or groups of with particular disease condition. To avoid bias many researchers advocate the use full developed by prespecifying predictors. Variable selection is not employed and resulting may be large complicated. In practice more parsimonious that retain most prognostic information preferred. We investigate effect on various performance measures, including mean square error classification, three methods...
OBJECTIVE. To assess the Pediatric Risk of Mortality (PRISM, PRISM III-12, and III-24) systems Index (PIM PIM2) for use in comparing risk-adjusted mortality children after admission pediatric intensive care United Kingdom. METHODS. All PICUs Kingdom were invited to participate. Predicted probability PICU was calculated using published algorithms PIM, PIM2, compared with observed mortality. These scores, along III-12 III-24, whose are not published, optimized RESULTS. Of 26 Kingdom, 22 (85%)...
Abstract —After successful surgical repair of an abdominal aortic aneurysm, patients have for many years increased risk death from cardiovascular causes. We tested the hypothesis that with aneurysms, nonaneurysm mortality before and after surgery aneurysm diameter. Records or rupture were available 2305 entered into UK Small Aneurysm Trial Study. Two hundred fifty-nine deaths occurred (mean follow-up 1.7 years), 325 3.6 years). The nonaneurysm-related diameter at baseline, even adjustment...
We sought to corroborate geographical differences in hepatitis C virus (HCV) prevalence and assess whether these can be explained by injecting risk behaviour. A community recruited interview survey of 1058 drug users (IDU) - including a blood spot specimen for antibody testing was undertaken seven cities England. HCV varied from 27% 74% across sites (chi(2)(6) = 115.3, P < 0.001). There significant variation crack-injection, prison history, frequency, homelessness, groin injecting, syringe...
<h3>Abstract</h3> <b>Objective:</b> To describe the epidemiology of HIV-1 infection in pregnant women United Kingdom. <b>Design:</b> Serial unlinked serosurveillance for neonatal specimens and surveillance through registers diagnosed maternal paediatric infections from reporting by obstetricians, paediatricians, microbiologists. <b>Setting:</b> Kingdom, 1988-96. <b>Subjects:</b> Pregnant proceeding to live births their children <b>Main outcome measures:</b> Time trends prevalence...
Abstract Introduction This report describes the case mix, outcome and activity (duration of intensive care unit [ICU] hospital stay, inter-hospital transfer, readmissions to ICU) for admissions ICUs acute severe asthma, investigates effect mix factors on outcome. Methods We conducted a secondary analysis data from high-quality clinical database (the Intensive Care National Audit Research Centre [ICNARC] Case Mix Programme Database) 129,647 128 adult, general critical units across England,...
<b>Objective: </b>To compare the risk factors for four common sexually transmitted infections (STIs) in attenders at three large urban genitourinary medicine (GUM) clinics England. <b>Methods: </b>Clinical, demographic, and behavioural data on two London one Sheffield were collected. Risk associated with first episodes of genital warts herpes simplex virus (HSV), uncomplicated gonorrhoea chlamydia investigated using presence each these STIs as outcome variable separate multiple logistic...