A5061394311- Acute Ischemic Stroke Management
- Stroke Rehabilitation and Recovery
- Obesity, Physical Activity, Diet
- Diabetes Management and Research
- Substance Abuse Treatment and Outcomes
- Smoking Behavior and Cessation
- Cancer survivorship and care
- Alcohol Consumption and Health Effects
- Health Systems, Economic Evaluations, Quality of Life
- Acute Myocardial Infarction Research
- Homelessness and Social Issues
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Diabetes Treatment and Management
- Mobile Health and mHealth Applications
- Heart Failure Treatment and Management
- Nutritional Studies and Diet
- Chronic Disease Management Strategies
- Diabetes and associated disorders
- Primary Care and Health Outcomes
- Health Promotion and Cardiovascular Prevention
- Emergency and Acute Care Studies
- Blood Pressure and Hypertension Studies
- Health Policy Implementation Science
- Venous Thromboembolism Diagnosis and Management
- Cardiac, Anesthesia and Surgical Outcomes
University of Newcastle Australia
2014-2024
Analysis & Policy Observatory
2019-2024
Policy Analysis (United States)
2018-2024
Hunter Medical Research Institute
2012-2023
John Hunter Hospital
2009-2018
Hamad Medical Corporation
2017
Florey Institute of Neuroscience and Mental Health
2016-2017
Monash University
2016-2017
Australian Catholic University
2017
La Trobe University
2017
Intravenous alteplase is the only approved treatment for acute ischemic stroke. Tenecteplase, a genetically engineered mutant tissue plasminogen activator, an alternative thrombolytic agent.
Although population-based molecular association studies are becoming increasingly popular, methodology for the meta-analysis of these has been neglected, particularly with regard to two issues: testing Hardy-Weinberg equilibrium (HWE), and pooling results in a manner that reflects biological model gene effect. We propose process from which consists following steps: (1) checking HWE using chi-square goodness fit; we suggest performing sensitivity analysis without HWE. (2) Heterogeneity is...
It is unknown whether collateral vessel status, as seen on computed tomography angiography, can predict the fate of penumbral tissue identified perfusion and thereby influence clinical outcome. We tested this hypothesis in consecutive patients who underwent tomography/computed angiography within 6 h anterior circulation stroke, also had repeat perfusion/infarct volume imaging at 24 h, modified Rankin Scale 3 months. Collateral status was graded good or reduced depending extent contrast...
Background— The hypothesis that paraoxonase (PON1) has a role in preventing atherosclerosis is based on experimental, transgenic, and case-control studies but not previously been tested prospectively. Methods Results— Caerphilly Prospective Study cohort study of men aged 49 to 65 years observed for coronary heart disease (CHD) events (fatal nonfatal myocardial infarction) over mean period 15 years. Serum PON1 activity toward paraoxon was measured 1353 participants. 20% lower the 163 who had...
To determine the separate and combined effects of high-protein (HP) high-fat (HF) meals, with same carbohydrate content, on postprandial glycemia in children using intensive insulin therapy (IIT).Thirty-three subjects aged 8-17 years were given 4 test breakfasts amount but varying protein fat quantities: low (LF)/low (LP), LF/HP, HF/LP, HF/HP. LF HF meals contained g 35 fat. LP HP 5 40 protein. An individually standardized dose was for each meal. Postprandial assessed by 5-h continuous...
<h3>Abstract</h3> <b>Objective:</b>To quantify the effects of quantity and frequency alcohol consumption on risk acute myocardial infarction coronary death. <b>Design:</b>Case-control study. <b>Setting:</b>Lower Hunter region New South Wales, Australia, 1983-94. <b>Subjects:</b>Men women aged 35-69 years. <b>Main outcome measure:</b>Acute or <b>Results:</b>Alcohol patterns were compared between 11 511 cases death 6077 controls randomly selected from same study population. After adjusting for...
The Women's Health Australia project provided the opportunity to examine prevalence of leaking urine and associated variables in three large cohorts Australian women 18-23 years age ("young" N = 14,761), 45-50 ("mid-age" 14,070), 70-75 ("older" 12, 893). proportion reporting was 12.8% (95% CI: 12.2-13.3), 36.1% (35.2- 37.0), 35% (34.1- 35.9) each cohorts, respectively. Logistic regression analysis showed significant associations between parity young mid-age women, constipation, other bowel...
Abstract Aims Vitamin D deficiency has been linked to impaired glucose metabolism. We determined whether serum 25‐hydroxyvitamin (25OHD) is associated with metabolism in pregnant women and the effect of ethnicity on this relationship. Methods analysed 25OHD concentrations 307 attending a metropolitan obstetric clinic between October 2003 May 2005. Measurements from 264 were taken at time tolerance testing mid‐gestation, population therefore increased risk for gestational diabetes. Pearson...
Clinical prediction of preterm delivery is largely ineffective, and the mechanism mediating progesterone (P) withdrawal estrogen activation at onset human labor unclear.Our objectives were to determine associations rates change circulating maternal CRH in midpregnancy with delivery, estriol (E3) concentrations late pregnancy, predelivery changes ratios E3, estradiol (E2), P.A cohort 500 pregnant women was followed from first antenatal visits during period 2000-2004 John Hunter Hospital, New...
Purpose: An enriched environment (EE) facilitates physical, cognitive and social activity in animal models of stroke. The aim this pilot study was to determine whether enriching the a mixed rehabilitation unit increased stroke patient activity. Methods: A non- randomized controlled trial conducted. Direct observation used difference change cognitive, or any over 2 weeks patients exposed an versus non-enriched environment. Results: Stroke EE (n = 15) were 1.2 (95% CI 1.0–1.4) times more...
Background. Diabetes mellitus and chronic kidney disease (CKD) are common exhibit synergistic associations with premature mortality. Current diabetes guidelines in the UK recommend annual urinary albumin serum creatinine determinations to screen for diabetic disease. The aim of this study was estimate burden CKD patients examine ability albuminuria detect clinically meaningful compared estimated glomerular filtration rate (eGFR).
In March 2008 the New South Wales judiciary restricted pub closing times to 3 a.m., and later 3.30 in central business district (CBD) of Newcastle, Australia. We sought determine whether restriction reduced incidence assault.Non-equivalent control group design with before after observations.Newcastle, a city 530,000 people.People apprehended for assault CBD nearby Hamilton, an area similar night-time economy but where no was imposed.Police-recorded assaults were compared those Hamilton....
We hypothesized that pretreatment magnetic resonance imaging (MRI) diffusion-weighted (DWI) and perfusion-weighted (PWI) lesion volumes may have influenced clinical response to thrombolysis in the Echoplanar Imaging Thrombolytic Evaluation Trial (EPITHET). In 98 patients randomized intravenous (IV) tissue plasminogen activator (tPA) or placebo 3 6 h after stroke onset, we examined increasing acute DWI PWI (Tmax—with 2-sec delay increments), PWI/DWI mismatch ratios, on odds of both excellent...
Abstract Objective The objective of this study was to identify caregivers' unmet needs and the psychosocial variables associated with need count within first 24 months post‐survivor diagnosis. Methods Caregivers completed a comprehensive survey measuring primary outcome, variables, demographics interest at 6 ( n = 547), 12 519), 443) Results Although prevalence significantly decreased over time, almost third caregivers still reported months. Unmet were more prevalent among lung cancer...
Background Multiple Sclerosis is more common in women than men and females have relapses men. In a large international cohort we evaluated the effect of gender on disability accumulation disease progression to determine if male MS patients worse clinical outcome females. Methods Using MSBase Registry, data from 15,826 25 countries was analysed. Changes severity (EDSS) were compared between sexes using repeated measures analysis generalised linear mixed models. Kaplan-Meier used test for sex...
<i>Background:</i> Perfusion computed tomography (PCT) shows promise in acute stroke assessment. However, the accuracy of CT perfusion thresholds defining infarct core remains uncertain. <i>Method:</i> Concurrent PCT and MRI-DWI performed 3–6 h after symptoms onset were assessed 57 ischemic patients. was compared to DWI images define using a pixel-based receiver operating characteristic curve analysis calculate area under (AUC) for from maps that coregistered with...
There is limited evidence for effective obesity treatment programs that engage men.This study evaluated the efficacy of two gender-tailored weight loss interventions men, which required no face-to-face contact.This was a three-arm, randomized controlled trial: (1) Resources (n = 54), materials (DVD, handbooks, pedometer, tape measure); (2) Online 53), plus website and e-feedback; (3) Wait-list control 52). The lasted 3 months were grounded in Social Cognitive Theory.At 6 months,...