A5017804509- Growth Hormone and Insulin-like Growth Factors
- Metabolism, Diabetes, and Cancer
- Diabetes Treatment and Management
- Diabetes Management and Research
- Diet and metabolism studies
- Diabetes and associated disorders
- Lipid metabolism and disorders
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Chronic Disease Management Strategies
- Lipoproteins and Cardiovascular Health
- Diabetes Management and Education
- Neural dynamics and brain function
- Pancreatic function and diabetes
- COVID-19 Clinical Research Studies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Health Systems, Economic Evaluations, Quality of Life
- Pregnancy and preeclampsia studies
- Heart Failure Treatment and Management
- Birth, Development, and Health
- Bariatric Surgery and Outcomes
- Liver Disease Diagnosis and Treatment
- Neurobiology and Insect Physiology Research
- Hormonal and reproductive studies
- Pharmacology and Obesity Treatment
- COVID-19 and healthcare impacts
Salford Royal Hospital
2012-2025
University of Manchester
2015-2025
Manchester Academic Health Science Centre
2016-2025
Salford Royal NHS Foundation Trust
2015-2024
Health Sciences Centre
2020-2024
Manchester University
2008-2023
Health Education North West
2021
Diabetes Australia
2020
Beaumont Health
2020
NIHR Clinical Research Network
2011-2019
We defined spatial patterns of tactile projections to cerebellar cortex anesthetized albino rats using microelectrode micromapping methods. Low threshold natural stimulation cutaneous mechanoreceptors specific body structures evokes brisk, short latency, localized responses within the granule cell layer. These terminate columnar assemblies cells folia crus I, II and paramedian lobule hemispheres. inputs appear as individuated patches overall array make up mosaics. The somatotopic...
Evidence for the management of chronic obstructive pulmonary disease (COPD) comes from closely monitored efficacy trials involving groups patients who were selected on basis restricted entry criteria. There is a need randomized to be conducted in conditions that are closer usual clinical practice.In controlled effectiveness trial 75 general practices, we randomly assigned 2799 with COPD once-daily inhaled combination fluticasone furoate at dose 100 μg and vilanterol 25 (the...
Background. Diabetes mellitus and chronic kidney disease (CKD) are common exhibit synergistic associations with premature mortality. Current diabetes guidelines in the UK recommend annual urinary albumin serum creatinine determinations to screen for diabetic disease. The aim of this study was estimate burden CKD patients examine ability albuminuria detect clinically meaningful compared estimated glomerular filtration rate (eGFR).
Cardiometabolic disease is more common in patients with schizophrenia than the general population.The purpose of study was to assess lifestyle factors, including diet and exercise, estimate prevalence metabolic syndrome.This a cross-sectional representative group outpatients Salford, UK. An interview supplemented by questionnaires used diet, physical activity, cigarette alcohol use. Likert scales assessed subjects' views activity. A examination relevant blood tests were...
Wound healing, including re-epithelialization, is delayed in diabetes. Growth factors influence the healing process and amongst these, insulin-like growth factor (IGF) has been shown to stimulate keratinocyte proliferation vitro. Monoclonal antibodies 1 2 (IGF1 IGF2) were used investigate their distribution diabetic foot ulcers surrounding tissues by immunohistochemistry, compared with non-diabetic uninjured skin. IGF2 was found throughout epidermis (stratum granulosum, spinosum, basale) all...
OBJECTIVE—To determine the effectiveness of specialist nurse-led clinics for hypertension and hyperlipidemia provided diabetic patients receiving hospital-based care. RESEARCH DESIGN AND METHODS—This study was a randomized controlled implementation trial at Hope Hospital, Salford, U.K. The subjects consisted 1,407 presenting annual review with raised blood pressure (≥140/80 mmHg), total cholesterol (≥5.0 mmol/l), or both. Individuals diabetes were to usual care subsequent invitation attend...
We have determined the phosphorylation pattern of circulating insulin-like growth factor-binding protein-1 (IGFBP-1) in normal subjects and assessed how this changes pregnancy. Two RIAs employing different monoclonal antibodies (MAbs 6303 or 6305) were used to measure IGFBP-1. In subjects, RIA measured 11-fold higher levels than 6305 (72.8 vs. 6.6 micrograms/L; P < 0.008). However, amniotic fluid (AF), two assays gave similar results. Immunoprecipitation plasma AF with MAb before nonsodium...
IGFs and their binding proteins are increasingly recognised as important in understanding the pathogenesis of cardiovascular disease. Low IGFBP-1, particularly coupled with low IGF-I, is associated increased risk. In relation to structural regulatory parallels between IGFBP-1 - 2 we have now examined hypothesis that IGFBP-2 may be a marker for risk.Fasting IGFBP-2, IGFBP-3, IGF-II, insulin, C-peptide, glucose, lipids, NEFAs, HbA1c were measured cohort 163 patients type diabetes. Individuals...
We examined stimulus-response relationships of vibrissa-activated mechanosensory neurons the rat's fifth (trigeminal) ganglion. Single-unit activity was recorded with tungsten microelectrodes. The vibrissae were deflected a variety parametrically controlled stimulus waveforms.We found that receptive field each neuron consisted single vibrissa. Few, if any, unambiguous examples spontaneous observed in these neurons. Even true present, its incidence low, as measured discharge rates.Thresholds...
We defined spatial patterns of organization projections from somatosensory cerebral cortex (SI) to the cerebellar anesthetized albino rats using microelectrode (stimulation and recording) micromapping methods low-threshold cutaneous (tactile) stimulation. Two sampling strategies were used: (1) a single SI locus in layers V-VI was stimulated electrically, while responding region granule cell (GC) layer systematically mapped with recording electrode; (2) stimulating electrode used as mapping...
Mechanosensory neurons are often classified as either rapidly adapting or slowly adapting. We examined response decay (adaptation) during constant deflection of the vibrissae with quantitative, repeatable, ad hoc measures. found that first-order vibrissa-activated fifth ganglion exhibit a variety adaptation rates appear to be distributed continuously between and extremes. Also, rate is influenced markedly by stimulus magnitude. no evidence for dichotomy within more on basis discharge...
Journal Article REPEATED CORTICOSTEROID INJECTIONS INTO KNEE JOINTS Get access H. W. BALCH, BALCH Rheumatology Unit, City HospitalAberdeen Request for reprints to Dr. Balch. Search other works by this author on: Oxford Academic PubMed Google Scholar J. M. C. GIBSON, GIBSON A. F. EL-GHOBAREY, EL-GHOBAREY L. S. BAIN, BAIN P. LYNCH Rheumatology, Volume 16, Issue 3, August 1977, Pages 137–140, https://doi.org/10.1093/rheumatology/16.3.137 Published: 01 1977
We discovered a small tactile area in single folium of the uvula caudal vermis rat's cerebellum. Gentle mechanical stimulation relatively cutaneous receptive fields (RFs) activated multiple units granule cell (GC) layer portion rats anesthetized with sodium pentobarbital. The total size this on each side midline is about 1.5 mm2, yet micromapping within tiny region using tungsten ball microelectrodes and high puncture sampling density (about 75 punctures/mm2) revealed highly differentiated...
1. The results of excision calcaneo-navicular bars in spasmodic flat feet are reported. average follow-up was six years. Complete relief symptoms achieved 68 per cent and over 25 degrees subtalar inversion restored 58 the feet. 2. appear slightly more favourable than those conservative treatment, but it is realised that period observation short. 3. In a selected group patients operation by standard technique relieved movement all. 4. It submitted bar justifiable procedure younger patient...
To determine whether the prevalence of physical comorbidities in Australian Vietnam War veterans with post-traumatic stress disorder (PTSD) is higher than trauma-exposed without PTSD.Cross-sectional analysis health status (based on self-reported and objective clinical assessments) 298 enrolled by Gallipoli Medical Research Institute (Brisbane) during February 2014 - July 2015, whom 108 were confirmed as having had PTSD 106 served control participants.Main outcomes measures: Diagnostic...
Type 2 diabetes is associated with biochemical evidence of low-grade inflammation, and experimental studies have suggested that both insulin glucose affect inflammatory responses. To determine the effect in vivo changes availability plasma concentrations humans, we administered 20 U/kg Escherichia coli lipopolysaccharide (LPS) or saline (control) to 14 subjects during a euglycemic hyperinsulinemic clamp ( n = 6) an infusion sterile 8). Parallel vitro on human whole blood were undertaken...
OBJECTIVE— To determine whether Pro-Active Call Center Treatment Support (PACCTS), using trained nonmedical telephonists supported by specially designed software and a diabetes nurse, can effectively improve glycemic control in type 2 diabetes. RESEARCH DESIGN AND METHODS— A randomized controlled implementation trial of 1-year duration was conducted Salford, U.K. The comprised 591 randomly selected individuals with By random allocation, 197 were assigned to the usual care (control) group 394...